Early Diagnosis of Disseminated<i>Mycobacterium genavense</i>Infection

Lastours, Victoire de; Guillemain, R.; Mainardi, Jean–Luc; Aubert, Agnès; Chevalier, P.; Lefort, A.; Podglajen, Isabelle

doi:10.3201/eid1401.070901

Cited by 29 publications

(3 citation statements)

References 9 publications

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“…Secondary dissemination occurred in one case. M. genavense infection has previously been reported in only two solid organ (kidney and heart) transplanted patients [ 10 , 11 ]. Both had intestinal involvement leading to secondary dissemination and death in one case [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

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Mycobacterium genavense as a cause of subacute pneumonia in patients with severe cellular immunodeficiency

et al. 2011

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BackgroundMycobacterium genavense is a rare nontuberculous mycobacteria (NTM). Human infections are mostly disseminated in the setting of the AIDS epidemic or the use of aggressive immunosuppressive treatments. M. genavense culture is fastidious, requiring supplemented media. Pulmonary involvement rarely occurs as a primary localization.Cases presentationWe report here two patients with pneumonia as the predominant manifestation of M. genavense infection: one kidney transplanted patient and one HIV-infected patient. Both patients were initially treated with anti-tuberculous drugs before the identification of M. genavense on sputum or broncho-alveolar lavage fluid culture. A four-drug regimen including clarithromycin and rifabutin was started. Gamma interferon has been helpful in addition to antimycobacterial treatment for one patient.ConclusionClinicians should be aware that M. genavense could be the etiologic agent of sub-acute pneumonia mimicking tuberculosis in patients with cellular immunodeficiency status.

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Section: Discussionmentioning

confidence: 99%

“…10 days- max. 6 months) depending on the culture medium [ 5 , 9 , 11 , 13 , 15 - 18 ]. Our observations are in agreement with these findings, In our first case, diagnosis was delayed because the time to positive culture was 70 days.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium genavense as a cause of subacute pneumonia in patients with severe cellular immunodeficiency

et al. 2011

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“…M. genavense is a slow-growing, nontuberculous mycobacterium that infects immunocompromised hosts ( 4 ). Only 3 cases of M. genavense infection in solid-organ transplant recipients have been reported ( 5 – 7 ). M. genavense has a predilection for the digestive tract, which explains the severity of the gastrointestinal symptoms ( 4 ).…”

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confidence: 99%

Identification of Cause of Posttransplant Cachexia by PCR

Guitard¹,

Edouard²,

Lépidi³

et al. 2012

Emerg. Infect. Dis.

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Mycobacterium genavense invading the bone marrow in a HIV‐positive patient

Bourlon

Vargas-Serafin

López‐Karpovitch

2017

Clinical Case Reports

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Key Clinical MessageNontuberculous mycobacteria infrequently cause disseminated infections in immunocompetent hosts. However, they are increasingly being recognized in immunocompromised patients. We present the case of a 40‐year‐old HIV‐positive male presenting with lymphadenopathies and pancytopenia in whom disseminated infection, with bone marrow involvement by Mycobacterium genavense (M. genavense) was diagnosed.

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Early Diagnosis of DisseminatedMycobacterium genavenseInfection

Cited by 29 publications

References 9 publications

Mycobacterium genavense as a cause of subacute pneumonia in patients with severe cellular immunodeficiency

Mycobacterium genavense as a cause of subacute pneumonia in patients with severe cellular immunodeficiency

Identification of Cause of Posttransplant Cachexia by PCR

Mycobacterium genavense invading the bone marrow in a HIV‐positive patient

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