Early Diagnosis of Brain Injury in Premature Infants Based on Amplitude-Integrated EEG Scoring System

Abstract

Analyzing and discussing the relationship between brain injury in preterm infants and related risk factors can provide evidence for perinatal prevention and early intervention of brain injury in preterm infants, thereby improving the quality of life of preterm infants. This paper selects term preterm infants diagnosed with preterm infant asphyxia in the NICU of a university’s First Affiliated Hospital from January 2018 to February 2019 as the research object. In addition, healthy term infants born at the same time in the obstetric department of this hospital are selected as the control group. Both groups of premature infants were monitored for brain function within 6 hours after birth. The aEEG results range from background activity (continuous normal voltage, discontinuous normal voltage, burst suppression, continuous low voltage, and plateau) and sleep-wake cycle (no sleep-wake cycle, immature, and mature sleep-wake cycle) to epileptic activity (single seizures, recurrent seizures, and status epilepticus), three aspects to judge. Statistical analysis uses SPSS 17.0 software. Amplitude-integrated EEG is a simplified form of continuous EEG recording. The trace of the trace represents the voltage change signal of the entire EEG background activity, which can reflect the EEG amplitude, frequency, burst-inhibition, and other pieces of information. aEEG can reflect the degree of HIE lesions in premature infants and the long-term prognosis. It is easy to operate and effective in diagnosis and can be continuously monitored. It is worthy of clinical popularization. There is a good correlation between the expression of EEG and biomarkers. Combining multiple methods can diagnose HIE earlier and evaluate the prognosis.

An Introduction to Neonatal EEG

“…Research findings support the prognostic value of aEEG in assessing general neurological well-being and in determining the long-term outcome of both the term and preterm infants 23,24. However, its use for neonatal seizure detection is more limited 4,25…”

“…Research findings support the prognostic value of aEEG in assessing general neurological well-being and in determining the long-term outcome of both the term and preterm infants. 23,24 However, its use for neonatal seizure detection is more limited. 4,25 Although EEG has been recommended as the gold standard for identifying neonatal seizures by the World Health Organization and the American Neurophysiology Society, it is not consistently used in neonatal units.…”

Amplitude EEG Changes in Preterm Infants at NICU of Al-Zahraa University Hospital

“…The brain damage caused by many risk factors such as PROM, preeclampsia and perinatal asphyxia often causes the death of premature infants and subsequent neurological development disorders such as cerebral palsy, epilepsy, men-tal retardation, and visual and auditory impairments [19]. Impaired cerebral activity, as reflected by depressed activity or absence of cycling in aEEG recorded during the first 3 days of life, was reported by different researchers using different methodologies, to be predictive of white matter injury, short and long term adverse outcomes [20].…”

Retracted: Early Diagnosis of Brain Injury in Premature Infants Based on Amplitude-Integrated EEG Scoring System

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”