“…Although treatment can delay or slow progression, the diet does not prevent the chorioretinopathy, highlighting a need for a retina-specific treatment for LCHADD chorioretinopathy. [17][18][19][20] Unfortunately, research into LCHADD chorioretinopathy has been limited due to the lack of model organisms. To address this problem, we recently reported a novel LCHADD mouse model that is homozygous for the c.G1528C variant in Hadha and recapitulated many of the human phenotypes.…”