Early developmental exposure to high fructose intake in rats with NaCl stimulation causes cardiac damage

Araujo, Iara Cristina; Andrade, Romario; Santos, Fernando dos; Soares, Edilene Siqueira; Yokota, Rodrigo; Mostarda, Cristiano Teixeira; Fiorino, Patricia; Angelis, Kátia De; Irigoyen, Maria-Cláudia; Morris, Mariana; Farah, Vera

doi:10.1007/s00394-014-0826-5

Cited by 13 publications

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“…The fructose overload induced glucose intolerance and/or insulin resistance, unfavorable changes in lipid profile, as well as an increase in adipose tissue in male and female adults and developing animals [6, 7, 8, 21]. Indeed, our study showed that physical training was able to prevent these metabolic alterations induced by fructose overload as previous reported by others studies [5, 17, 34, 35, 36].…”

Section: Discussionsupporting

confidence: 86%

“…In fact, our group has previously shown that fructose overload in adult male rats exhibited diastolic dysfunction and increased MPI [21], and exercise training performed during the same period eliminated all of these derangements [36]. A study conducted with patients with metabolic syndrome showed reversed E/A ratio, suggesting impaired LV relaxation, the first stage of LV diastolic dysfunction, and combined exercise training undertaken for a year did not improve LV diastolic function in those individuals [28, 44].…”

Section: Discussionmentioning

confidence: 99%

“…IN). Animals received a dose of 1.5 g/kg body weight intraperitoneally (intraperitoneal glucose) and a drop of blood from the end of the tail was collected at baseline and 15, 30, 60, 90 and 120 minutes after the glucose injection [21]. Triglycerides and total cholesterol were analyzed in the serum by the chemiluminescent method (Lab test, Brazil).…”

Section: Methodsmentioning

confidence: 99%

“…All measurements were based on the average of 3 consecutive cardiac cycles. Echocardiography parameters were measured as previously described [21, 22]. …”

Section: Methodsmentioning

confidence: 99%

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Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats

et al. 2016

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The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group): Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40–60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42±0.04 vs. SC:0.24±0.05) and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)- SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04), arterial pressure (118±2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…All measurements were based on the average of 3 consecutive cardiac cycles. Echocardiography parameters were measured as previously described [21, 22]. …”

Section: Methodsmentioning

confidence: 99%

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Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats

et al. 2016

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“…Animais que são tratados com frutose, independentemente da via de administração, apresentam distúrbios semelhantes aqueles encontrados na SM, como resistência à insulina, aumento dos triglicerídeos e da insulina plasmática e hipertensão (YOSHIDA et al, 2003;BRITO et al, 2008;ARAUJO et al, 2015).…”

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Curso temporal das alterações autonômicas e metabólicas da hipertensão por sobrecarga de frutose: papel do barorreflexo

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Autorizo a reprodução e divulgação total ou parcial deste trabalho, por qualquer meio convencional ou eletrônico, para fins de estudo e pesquisa, desde que citada a fonte. The increased consumption of fructose in recent decades is closely associated with the higher incidence of obesity, metabolic syndrome and associated comorbidities, such as Dyslipidemia, Dysautonomia, and diabetes. However, the literature does not present temporal characterization of the events that occur until the establishment of the diseases. On this basis, this work aims to evaluate the temporal autonomic and metabolic changes in metabolic syndrome model induced by fructose overload, with emphasis on the role of the baroreflex, here tested using sinoaortic denervation. Additionally, we intend to identify in this model, if autonomic changes precede or follow the metabolic changes. Four experimental groups were used (rats), followed by 90 days: control (C), treated with fructose (F), sinoaortic denervated (D) and denervated treated with fructose (DF). Fructose overload was performed using drinking water solution (10%). Blood pressure recording was performed via radio telemetry for 13 weeks. Fructose was able to promote development of metabolic syndrome, causing blood pressure, fasting blood glucose and abdominal fat increase and changing lipid profile (from the seventh week to thirteenth week of treatment). Dados Internacionais de Catalogação na Publicação (CIP)PreparadaAutonomic changes, characterized by increased cardiac and peripheral sympathetic modulation, occurred in the second week of Protocol. Fructose group presented changes of renal function and inflammation. The baroreflex seems to participate in the changes induced by fructose during the development of the metabolic syndrome, since his absence determines changes in various metabolic parameters in addition to the expected hemodynamic. Additionally, fructose treatment induced late functional impairment of blood pressure reflex control. Based on our results we can conclude that the changes in autonomic control precede and probably contribute to the metabolic changes induced by the excessive consumption of fructose.Descriptors: autonomic nervous system diseases; metabolic syndrome X;inflammation; blood pressure; fructose; sympathetic nervous system; baroreflex. (ELLIOTT et al., 2002;STANHOPE et al., 2015). Relação de figuras Relação de tabelasExperimentalmente, um modelo simples para indução de SM é através de ração comercial rica em frutose (60%) (HWANG et al., 1987) ou adicionando frutose na água de beber (10 a 20%) (DAI & MCNEILL, 1995). Animais que são tratados com frutose, independentemente da via de administração, apresentam distúrbios semelhantes aqueles encontrados na SM, como resistência à insulina, aumento dos triglicerídeos e da insulina plasmática e hipertensão (YOSHIDA et al., 2003;BRITO et al., 2008;ARAUJO et al., 2015).Nesse contexto, nosso grupo tem trabalhado com animais tratados com frutose, demonstrando diversas alterações autonômicas, como menor atividade va...

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Modulation of renin angiotensin system components by high glucose levels in the culture of collecting duct cells

Leite

Aragão

Nogueira

et al. 2019

Journal Cellular Physiology

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Diabetes mellitus and its complications have become a major health concern in Western countries. Increased activity of the intrarenal renin-angiotensin system (RAS) contributes to diabetic nephropathy (DN). We previously reported that in mesangial cells, the high glucose concentration (HG) leads to upregulation of angiotensin-converting enzyme (ACE) messenger RNA, suggesting that ACE was modulated by angiotensin II (Ang II) release. However, this relation in the collecting duct has not yet been studied. We, therefore, aimed to evaluate RAS modulation in inner medullary collecting duct cells (IMCD) exposed to HG. The IMCD were divided into normal glucose (5 mM D-glucose, NG), high glucose (30 mM, HG), and mannitol (30 mM, M) groups. The cells were cultured 48 hr in their respective media. The intracellular and extracellular ACE activity was measured using hippuryl-His-Leu as substrate via a fluorimetric assay and expression was analyzed using western blot analysis. ACE activity, intracellular (27%) and extracellular (22%), was significantly lower in the HG group than in NG and M. ACE2 activity and Ang 1-7 levels were higher in the intracellular compartment. Our data suggest that the HG cannot modify ACE synthesis in IMCD cells but can modulate its activity. The decrease in ACE activity may result in decreased levels of Ang II to protect the IMCD against proliferative and inflammatory deleterious effects of this peptide. Conversely, the increase of ACE2 generating high levels of Ang 1-7, a vasodilator peptide, suggesting that this peptide can induce glucose uptake and protect cells against oxidative stress, which can elicit insulin resistance. K E Y W O R D Scollecting duct, diabetes, high glucose, mIMCD-3, renin-angiotensin system

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Early developmental exposure to high fructose intake in rats with NaCl stimulation causes cardiac damage

Abstract: Data suggest that early exposure to high fructose intake produced marked alterations in metabolic and cardiovascular function. When stimulated by NaCl, the fructose-fed subjects showed further impairment in cardiac function.

Cited by 13 publications

References 50 publications

Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats

Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats

Curso temporal das alterações autonômicas e metabólicas da hipertensão por sobrecarga de frutose: papel do barorreflexo

Modulation of renin angiotensin system components by high glucose levels in the culture of collecting duct cells

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