Early Development of Innate Lymphoid Cells

Ding, Yi; Harly, Christelle; Das, Arundhoti; Bhandoola, Avinash

doi:10.1007/978-1-0716-2740-2_3

Cited by 2 publications

(5 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NFIL3-mediated effects on ILC commitment are proposed to be due to its regulation of ID2 and TOX expression. [95][96][97][98][99][100]102 Tissue niches are thought to play an important role in transcriptional regulation of group 1 ILC development. Tcf7.…”

Section: Nfil3mentioning

confidence: 99%

“…4,19,20,23 It is believed that TCF1 promotes ILC development by promoting expression of ILC related genes like IL7r, Id2, and Gata3 while inhibiting myeloid/dendritic cell lineage genes. 20,102 Tcf7 also plays an important role in functional maturation of NK cells, as its expression declines as NK cells mature and plummets to minimal levels in terminally mature CD11b NK cells. 109 Tcf7 negatively regulates granzyme B expression by directly binding to granzyme B regulatory elements in NK cells.…”

Section: Nfil3mentioning

confidence: 99%

“…Accordingly, Nfil3 −/− mice have very few CHILPs and ILCPs and hence subsequent development of all ILC subsets including ILC1s is severely contracted. NFIL3‐mediated effects on ILC commitment are proposed to be due to its regulation of ID2 and TOX expression 95–100,102 . Tissue niches are thought to play an important role in transcriptional regulation of group 1 ILC development.…”

Section: Major Transcriptional Regulators Of Group 1 Ilcsmentioning

confidence: 99%

“…Thus, ILC1 and NK cell developmental defects are attributed to impaired progenitor commitment and limited progenitor numbers in Tcf7 deficient mice 4,19,20,23 . It is believed that TCF1 promotes ILC development by promoting expression of ILC related genes like IL7r , Id2 , and Gata3 while inhibiting myeloid/dendritic cell lineage genes 20,102 . Tcf7 also plays an important role in functional maturation of NK cells, as its expression declines as NK cells mature and plummets to minimal levels in terminally mature CD11b NK cells 109 .…”

Section: Major Transcriptional Regulators Of Group 1 Ilcsmentioning

confidence: 99%

See 3 more Smart Citations

Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation

Sudan,

Gilfillan,

Colonna

2024

Immunological Reviews

View full text Add to dashboard Cite

SummaryGroup 1 innate lymphoid cells (ILCs), comprising ILC1s and natural killer cells (NK cells), belong to a large family of developmentally related innate lymphoid cells that lack rearranged antigen‐specific receptors. NK cells and ILC1s both require the transcription factor T‐bet for lineage commitment but additionally rely on Eomes and Hobit, respectively, for their development and effector maturation programs. Both ILC1s and NK cells are essential for rapid responses against infections and mediate cancer immunity through production of effector cytokines and cytotoxicity mediators. ILC1s are enriched in tissues and hence generally considered tissue resident cells whereas NK cells are often considered circulatory. Despite being deemed different cell types, ILC1s and NK cells share many common features both phenotypically and functionally. Recent studies employing single cell RNA sequencing (scRNA‐seq) technology have exposed previously unappreciated heterogeneity in group 1 ILCs and further broaden our understanding of these cells. Findings from these studies imply that ILC1s in different tissues and organs share a common signature but exhibit some unique characteristics, possibly stemming from tissue imprinting. Also, data from recent fate mapping studies employing Hobit, RORγt, and polychromic reporter mice have greatly advanced our understanding of the developmental and effector maturation programs of these cells. In this review, we aim to outline the fundamental traits of mouse group 1 ILCs and explore recent discoveries related to their developmental programs, phenotypic heterogeneity, plasticity, and transcriptional regulation.

show abstract

Section: Nfil3mentioning

confidence: 99%

Section: Nfil3mentioning

confidence: 99%

Section: Major Transcriptional Regulators Of Group 1 Ilcsmentioning

confidence: 99%

Section: Major Transcriptional Regulators Of Group 1 Ilcsmentioning

confidence: 99%

See 2 more Smart Citations

Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation

Sudan,

Gilfillan,

Colonna

2024

Immunological Reviews

View full text Add to dashboard Cite

show abstract

“…Innate lymphoid cells (ILCs) are mainly tissue-resident cells with rapid activation by microenvironmental stimuli [ 141 ]. Localized preferentially in mucosal barriers, they play a role in monitoring and maintaining innate immunity.…”

Section: Mitochondrial Metabolism In Innate Immune Cellsmentioning

confidence: 99%

Mitochondrial Damage-Associated Molecular Patterns and Metabolism in the Regulation of Innate Immunity

Lyu,

Wang,

Huang

et al. 2023

J Innate Immun

View full text Add to dashboard Cite

The innate immune system, as the host’s first line of defense against intruders, plays a critical role in recognizing, identifying, and reacting to a wide range of microbial intruders. There is increasing evidence that mitochondrial stress is a major initiator of innate immune responses. When mitochondria’s integrity is disrupted or dysfunction occurs, the mitochondria’s contents are released into the cytosol. These contents, like reactive oxygen species, mitochondrial DNA, and double-stranded RNA, among others, act as damage-related molecular patterns (DAMPs) that can bind to multiple innate immune sensors, particularly pattern recognition receptors, thereby leading to inflammation. To avoid the production of DAMPs, in addition to safeguarding organelles integrity and functionality, mitochondria may activate mitophagy or apoptosis. Moreover, mitochondrial components and specific metabolic regulations modify properties of innate immune cells. These include macrophages, dendritic cells, innate lymphoid cells, and so on, in steady state or in stimulation that are involved in processes ranging from the tricarboxylic acid cycle to oxidative phosphorylation and fatty acid metabolism. Here we provide a brief summary of mitochondrial DAMPs’ initiated and potentiated inflammatory response in the innate immune system. We also provide insights into how the state of activation, differentiation, and functional polarization of innate immune cells can be influenced by alteration to the metabolic pathways in mitochondria.

show abstract

Early Development of Innate Lymphoid Cells

Cited by 2 publications

References 106 publications

Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation

Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation

Mitochondrial Damage-Associated Molecular Patterns and Metabolism in the Regulation of Innate Immunity

Contact Info

Product

Resources

About