Early determination of cystic fibrosis by electrochemical chloride quantification in sweat

Gonzalo‐Ruiz, Javier; Mas, Roser; Haro, Carmen de; Cabruja, E.; Camero, Rafael; Alonso‐Lomillo, M. Asunción; Muñoz, F. Javier

doi:10.1016/j.bios.2008.07.051

Cited by 100 publications

(62 citation statements)

References 19 publications

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“…Li-ISEs are generally sensitive to high sodium concentration [14,15] but in saliva the sodium levels are three order of magnitude lower [35]. However, to date, examples of convincing wearable ISE-sensors are few and limited to sodium and chloride [20,24]. Significantly, the results in the two latter references correlated with the ones from Atomic Absorption Spectroscopy (AAS) which is surely an encouragement to push forward into this direction.…”

Section: Introductionsupporting

confidence: 71%

“…The latter fact would support their potential use in wearable applications in the monitoring of clinical important analytes in sweat, saliva and interstitial fluids when good correlation between blood plasma with these body fluids exists. The current focus on point-of-care and self diagnostics encourages the use of ISEs for these applications [9,20,24]. There are many analytes in sweat and saliva whose monitoring would be extremely important [24][25][26][27][28][29][30][31][32][33][34] and hereafter few examples are reported.…”

Section: Introductionmentioning

confidence: 99%

“…On the wearable side, for example, levels of sodium, potassium and chloride in sweat have been used as early diagnostic tool of cystic fibrosis (CF) [20][21][22][23][24]. However, it is worth to note that, to date, the US Cystic Fibrosis Foundation has not approved the use of ISEs for in sweat diagnosis of cystic fibrosis [24].…”

Section: Introductionmentioning

confidence: 99%

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Opportunities and challenges of using ion-selective electrodes in environmental monitoring and wearable sensors

Zuliani

Diamond

2012

Electrochimica Acta

107

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Great opportunities exist for Ion-Selective Electrodes (ISEs) in the fields of environmental monitoring and of wearable applications for example as the sensing part in wireless networks.In this review special attention is given to the recent results obtained with Solid Contact IonSelective Electrodes and Solid Contact Reference Electrodes. Their combination as disposable sensing platform may offer the best solution to eliminate issues commonly experienced with ISEs and lead in a short term to their commercialization. Future research will likely focus on the miniaturization of the current devices and on the further development of non conventional potentiometric methods, e.g., controlled potential thin-layer coulometry.2 Contents.

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Section: Introductionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

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Opportunities and challenges of using ion-selective electrodes in environmental monitoring and wearable sensors

Zuliani

Diamond

2012

Electrochimica Acta

107

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“…gold standard for screening cystic fibrosis (CF), a genetic chronic disease that affects lungs and digestive system (21)(22)(23). A strong correlation between blood and sweat ethanol concentrations has been reported which could enable continuous blood-alcohol monitoring by sweat analysis (24,25).…”

Section: Significancementioning

confidence: 99%

“…S5). Ag/AgCl electrodes were chosen for chloride ion detection (23) whereas the measurement of sodium ions was achieved by using previously reported sodium ionophore X selectophore-based ion-selective electrodes (15). A polyvinyl butyral (PVB)-coated electrode containing saturated chloride ions was chosen as the reference electrode due to its stable potentials in different analyte solutions (16).…”

Section: Significancementioning

confidence: 99%

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform

Emaminejad

Gao

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

642

583

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Perspiration-based wearable biosensors facilitate continuous monitoring of individuals' health states with real-time and molecular-level insight. The inherent inaccessibility of sweat in sedentary individuals in large volume (≥10 μL) for on-demand and in situ analysis has limited our ability to capitalize on this noninvasive and rich source of information. A wearable and miniaturized iontophoresis interface is an excellent solution to overcome this barrier. The iontophoresis process involves delivery of stimulating agonists to the sweat glands with the aid of an electrical current. The challenge remains in devising an iontophoresis interface that can extract sufficient amount of sweat for robust sensing, without electrode corrosion and burning/causing discomfort in subjects. Here, we overcame this challenge through realizing an electrochemically enhanced iontophoresis interface, integrated in a wearable sweat analysis platform. This interface can be programmed to induce sweat with various secretion profiles for real-time analysis, a capability which can be exploited to advance our knowledge of the sweat gland physiology and the secretion process. To demonstrate the clinical value of our platform, human subject studies were performed in the context of the cystic fibrosis diagnosis and preliminary investigation of the blood/sweat glucose correlation. With our platform, we detected the elevated sweat electrolyte content of cystic fibrosis patients compared with that of healthy control subjects. Furthermore, our results indicate that oral glucose consumption in the fasting state is followed by increased glucose levels in both sweat and blood. Our solution opens the possibility for a broad range of noninvasive diagnostic and general population health monitoring applications.W earable biosensors have received considerable attention owing to their great promise for a wide range of clinical and physiological applications (1-10). Despite significant progress made in printed and flexible biosensors in the field, a majority of wearable devices focus on monitoring of physical activity or selected electrophysiological parameters, providing only limited information regarding physiological changes of complex homeostatic responses (4-10). Wearable chemical sensors offer great opportunities for collecting physiological information at the molecular level (3,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Recently research advances have resulted in a variety of wearable sweat sensors that can be used for real-time analysis of sweat biomarkers including electrolytes, metabolites, and heavy metals (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). We recently demonstrated a fully integrated wearable sensing system for real-time monitoring of multiple analytes in human perspiration during physical exercise which allows accurate measurement of sweat analytes through signal processing and calibration (16).The inherent inaccessibility of sweat in sedentary individuals in large volume (≥10 μL) for on-demand and in situ analysis remains to limit our ...

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Lab‐on‐a‐Chip Platforms for Disease Detection and Diagnosis

Işıksaçan

Güler

Kalantarifard

et al. 2017

Biosensors and Nanotechnology

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Early determination of cystic fibrosis by electrochemical chloride quantification in sweat

Cited by 100 publications

References 19 publications

Opportunities and challenges of using ion-selective electrodes in environmental monitoring and wearable sensors

Opportunities and challenges of using ion-selective electrodes in environmental monitoring and wearable sensors

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform

Lab‐on‐a‐Chip Platforms for Disease Detection and Diagnosis

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