Early detection of metastases using whole-body MRI for initial staging and routine follow-up of myxoid liposarcoma

Gorelik, Natalia; Reddy, Santhosh Mauvva Venkatesh; Turcotte, Robert; Goulding, Krista; Jung, Sungmi; Alcindor, Thierry; Powell, T.

doi:10.1007/s00256-017-2845-9

Cited by 35 publications

(25 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another limitation of this series was that the patients reviewed performed where largely the population of patients was surveilled using CT imaging to detect distant recurrence. There is a recent report that whole-body MRI may be more sensitive at detecting a pulmonary metastases compared with CT, and it is possible that this is more sensitive with regard to the detection of metastatic disease [ 18 ]. Furthermore, it is possible that at least some of the patients in this series could have been found to have metastatic disease even prior to the initiation of definitive therapy.…”

Section: Discussionmentioning

confidence: 99%

Myxoid Liposarcoma: Treatment Outcomes from Chemotherapy and Radiation Therapy

Chowdhry

Goldberg

DeLaney

et al. 2018

Sarcoma

View full text Add to dashboard Cite

Introduction Myxoid liposarcoma (MLS) is a subtype of liposarcoma characterized morphologically by lipomatous differentiation with a myxoid stroma. The purpose of this study was to review clinical and pathological information for patients treated for MLS at our institution to better understand neoadjuvant and adjuvant therapy. Materials and Methods An institutional database of sarcomas was queried for patients who were treated for MLS at our institution between 1992 and 2013. Survival curves were constructed using Kaplan–Meier analysis, and univariate and multivariate statistics were performed using the Cox-proportional hazards model and using linear regression. Results A total of 85 patients with myxoid liposarcoma were identified. The mean and median histologic response rate to treatment for patients who received preoperative radiation therapy was 77.6%. Five-year disease-free survival, distant metastasis-free survival, local recurrence-free survival, and overall survival were 78.6% (95% CI: 67.8–86.1), 84.7% (95% CI: 74.5–91.0), 95.6% (95% CI: 86.9–98.6), and 87.5% (95% CI: 77.2–93.3) respectively. On univariate analysis, there was a trend towards higher necrosis or treatment response rates in patients who received concurrent chemotherapy, 84.7% (95% CI: 75.9–93.4) and 69.5% (95% CI: 55.1–83.8), p=0.061. Tumor size was associated with inferior disease-free and overall survival. Hazard ratio for disease-free survival is 1.08 (per cm) (95% CI: 1.01–1.16), p=0.019. Conclusions Myxoid liposarcoma exhibits histological response to chemotherapy and radiation therapy. Tumor size appears to be greatest predictor of long-term disease control and overall survival. We were not able to show that chemotherapy provides a clinical benefit with regard to local control, disease-free survival, or overall survival. However, it is important to note that the selected usage of chemotherapy in the highest risk patients confounds this analysis. Further investigation is needed to help better determine the optimal use of chemotherapy in this group of patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Myxoid Liposarcoma: Treatment Outcomes from Chemotherapy and Radiation Therapy

Chowdhry

Goldberg

DeLaney

et al. 2018

Sarcoma

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Cardiac metastases from primary myxoid liposarcoma of the thigh: A case report

Ikuta

Sakai

Koike

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Myxoid liposarcoma is well known to have an unusual proclivity for extrapulmonary metastasis. However, cardiac metastasis of myxoid liposarcoma is very rare, even in patients with advanced disease. Case presentation: A 40-year-old man was diagnosed with myxoid liposarcoma of the right thigh and treated with wide resection. Two years after the surgery, a low-density area in the left ventricle was found on follow-up chest computed tomography, which was suspected of being metastatic disease. He underwent surgical treatment, and the lesion was pathologically confirmed as metastasis of myxoid liposarcoma. Fifteen months later, he complained of slight dyspnea and developed metastatic disease in the right atrium. He was treated with surgical excision for the disease, followed by radiotherapy. Although there has been no recurrence in the heart since the second cardiac metastasectomy, multiple metastases have occurred in the abdominal cavity, lungs, and muscles. He finally died of the disease at two years after the second cardiac metastasectomy. Conclusion: We experienced a case of primary myxoid liposarcoma in the thigh, accompanied by ectopic and metachronous cardiac metastases. Despite its dismal prognosis, surgical excision occasionally offers a chance to prolong survival in patients with no evidence of widespread metastases.

show abstract

“…For the staging of MLS at diagnosis, the 2017 National Comprehensive Cancer Network (NCCN) guidelines recommended chest imaging and abdominal/pelvic CT as well as total spine MRI [22]. Recent studies suggest that whole-body MRI is the most reliable modality for surveillance of all likely sites of extrapulmonary metastases [6,23]. Although our patient underwent chest CT and thigh MRI every 3-4 months and annual total spine MRI after surgery for the primary tumor, he did not follow-up with wholebody MRI.…”

Section: Discussionmentioning

confidence: 99%

Cardiac metastases from primary myxoid liposarcoma of the thigh: A case report

Ikuta

Sakai

Koike

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundMyxoid liposarcoma is well known to have an unusual proclivity for extrapulmonary metastasis. However, cardiac metastasis of myxoid liposarcoma is very rare, even in patients with advanced disease.Case presentationA 40-year-old man was diagnosed with myxoid liposarcoma of the right thigh and treated with wide resection. Two years after the surgery, a low-density area in the left ventricle was found on follow-up chest computed tomography, and was suspected of being metastatic disease. He underwent surgical treatment, and the lesion was pathologically confirmed as metastasis of myxoid liposarcoma. Fifteen months later, he complained of slight dyspnea and developed metastatic disease in the right atrium. He was treated with surgical excision, followed by radiotherapy. Although there was no recurrence in the heart since the second cardiac metastasectomy, multiple metastases occurred in the abdominal cavity, lungs, and muscles. He finally died of the disease two years after the second cardiac metastasectomy.ConclusionWe experienced a case of primary myxoid liposarcoma in the thigh, accompanied by ectopic and metachronous cardiac metastases. Although this condition is rare, we should follow-up patients with myxoid liposarcoma, considering the possibility of cardiac metastasis.

show abstract

Early detection of metastases using whole-body MRI for initial staging and routine follow-up of myxoid liposarcoma

Cited by 35 publications

References 27 publications

Myxoid Liposarcoma: Treatment Outcomes from Chemotherapy and Radiation Therapy

Myxoid Liposarcoma: Treatment Outcomes from Chemotherapy and Radiation Therapy

Cardiac metastases from primary myxoid liposarcoma of the thigh: A case report

Cardiac metastases from primary myxoid liposarcoma of the thigh: A case report

Contact Info

Product

Resources

About