Early detection of lymphomas in Sjögren's syndrome by in situ hybridisation for κ and λ light chain mRNA in labial salivary glands

Speight, PM; Jordan, Rck; Colloby, P.; Nandha, Hamalata; Pringle, J. H.

doi:10.1016/0964-1955(94)90005-1

Cited by 27 publications

(37 citation statements)

References 12 publications

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“…This approach deserves further attention in larger and multicenter studies, since the interpretation or quantification of light chain restriction by immunohistochemical analysis may often be difficult and subjective, especially in borderline cases. Recently proposed in situ hybridization studies might be more reliable (42). However, we stress the role of a careful clinical approach to the patient.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, molecular analyses should not be primarily targeted to such lesions in SS. Other investigators, however, have suggested that the dissemination of an overt malignant lymphoma could be highlighted by the detection of B cell clonality in benign lesions (11,42), although this issue is controversial (42,43). It is possible that less sensitive, nonmolecular analyses, i.e., the study of K / A light chain restriction on minor salivary gland infiltrates in SS, might be of some value to this end.…”

Section: Discussionmentioning

confidence: 99%

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Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome

Vita

Boiocchi

Sorrentino

et al. 1997

Arthritis & Rheumatism

104

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Objective. To determine whether the prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome (SS) may be better characterized by the integration of clinical, pathologic, and molecular data, the latter focusing on the expansion, persistence, and dissemination of clonal B cells in the course of the disease. Methods. Multiple tissue lesions (synchronous from different tissues and metachronous from the same tissue) were evaluated in biopsy specimens obtained from 6 consecutive patients with SS who had an associated lymphoproliferative disorder. Fully benign gastric lesions were evaluated in tissue from an additional 11 patients with SS who had no associated lymphoproliferative disorder. Multiple and complementary molecular analyses of B cell clonality were used: Southern blot, polymerase chain reaction, single‐strand conformation polymorphism, DNA sequencing, and hybridization with clonospecific oligoprobes. All the patients were then strictly followed up for the appearance of lymphoma. Results. Different scenarios of SS‐associated B cell lymphoproliferation were identified: 1) the ongoing expansion of the same dominant clone, localized or disseminated, in tissue from 2 patients, 1 of whom later developed an overt B cell lymphoma; 2) different dominant clones in different synchronous or metachronous tissues from the remaining 4 patients with an associated lymphoproliferative disorder; and 3) small oligoclonal expansions in 7 of the 11 benign gastric lymphoid infiltrates. Conclusion. Prelymphomatous B cell lymphoproliferation in SS was better characterized following integration of the findings. The different types of B cell clonal expansion (oligoclonal or monoclonal, smaller or larger in size, fluctuating or established, localized or disseminated) may imply a different risk of lymphoma progression. An accurate clinical, histopathologic, and molecular characterization may therefore be crucial in future studies aimed at clarifying the pathobiology of SS‐associated lymphoproliferation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome

Vita

Boiocchi

Sorrentino

et al. 1997

Arthritis & Rheumatism

104

View full text Add to dashboard Cite

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“…More recently, immunohistochemical and molecular studies have shown a high incidence of light-chain restriction in labial minor salivary glands (Bodeutsch et al, 1993;Speight and Jordan, 1993;Speight et al, 1994). In a large study of 70 labial glands from patients with Sjogren's syndrome, light-chain restriction was identified in 13 cases.…”

Section: Polyclonal and Monoclonal Gammopathies In Sjogren F S Syndromementioning

confidence: 99%

Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjögren's Syndrome

Fox

Speight

1996

Critical Reviews in Oral Biology & Medicine

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Sjogren's syndrome is a systemic autoimmune disorder characterized by symptoms of oral and ocular dryness and a chronic, progressive loss of salivary and lacrimal function. The exocrine involvement is the result of a focal, peri-ductal mononuclear cell infiltrate and the subsequent loss of secretory epithelial cells. The mechanisms of this autoimmune exocrinopathy are not understood fully. Many recent investigations have described alterations in a number of immune mediators within the salivary glands. These studies provide new insights into the immune regulation of normal salivary gland functions and the mechanisms of gland damage in Sjogren's syndrome.

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“…In late complications, 4%-7% of patients with SS develop B-cell lymphomas, among which 48%-75% are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma), frequently located in the parotid gland. MALT lymphoma affecting the minor salivary glands in SS patients is rare (6,7). It is interesting to note that, although obstructive phenomena by periductal lymphocytic infiltrates can be observed in minor salivary glands from SS patients, reactive lesions, such as oral mucocele, are uncommon (8).…”

Section: Introductionmentioning

confidence: 99%

Oral Nodular Lesions in Patients with Sjögren’s Syndrome: Unusual Oral Implications of a Systemic Disorder

et al. 2017

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Sjögren’s syndrome (SS) is a systemic chronic autoimmune disorder affecting the lacrimal and salivary glands. SS may manifest as primary SS (pSS) or secondary SS (sSS), the latter occurring in the context of another autoimmune disorder. In both cases, the dry eyes and mouth affect the patient’s quality of life. Late complications may include blindness, dental tissue destruction, oral candidiasis and lymphoma. This paper reports two cases of SS, each of them presenting unusual oral nodular lesion diagnosed as relapsed MALT lymphoma and mucocele. The importance of the diagnosis, treatment and management of the oral lesions by a dentist during the care of SS patients is emphasized, as the oral manifestations of SS may compromise the patient’s quality of life.

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Early detection of lymphomas in Sjögren's syndrome by in situ hybridisation for κ and λ light chain mRNA in labial salivary glands

Cited by 27 publications

References 12 publications

Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome

Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome

Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjögren's Syndrome

Oral Nodular Lesions in Patients with Sjögren’s Syndrome: Unusual Oral Implications of a Systemic Disorder

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