Early Detection of Lung Cancer: A Call for Novel Biomarkers-Review

Cherneva, Radostina; Georgiev, Ognian; Petrova, Diana

doi:10.1080/13102818.2007.10817435

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…The histology-directed approach has also been applied to pre-invasive lung lesions. Lung cancer has one of the lowest 5 year survival rates (,15%) of any cancer, especially when it has progressed beyond stage 1 [30]. To this end, efforts are being made to establish means of early detection of high-risk individuals.…”

Section: Ms Protein Analysismentioning

confidence: 99%

Imaging mass spectrometry: Towards clinical diagnostics

Seeley

Caprioli

2008

Proteomics Clinical Apps

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Imaging MS (IMS) has emerged as a powerful tool for biomarker discovery. A key advantage of this technique is its ability to probe the proteome directly from a tissue section with preservation of the spatial relationships of the sample and minimal sample preparation. This allows for direct correlation of protein expression with histology. Here, we present the latest developments in imaging MS and their relevance to clinical mass spectral analysis. IMS allows for high throughput analysis of tissue samples and is fully compatible with biostatistical analysis without prior knowledge of protein expression. Several studies are presented of applications in which direct tissue mass spectral analysis has provided insight into clinical questions not readily available by other means. Examples include the determination of lymph node status from investigation of primary breast tumors, prediction of response of breast tumors to chemotherapy, classification and prediction of progression of lung lesions, and exploration of 'molecular' margins in invasive disease.

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Section: Ms Protein Analysismentioning

confidence: 99%

Imaging mass spectrometry: Towards clinical diagnostics

Seeley

Caprioli

2008

Proteomics Clinical Apps

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“…Πνιιέο πξσηεΐλεο φκσο πνπ ππεξεθθξάδνληαη ζηα θχηηαξα ησλ φγθσλ, έρνπλ απμεκέλε έθθξαζε ζηα αλαδηπιαζηαδφκελα θχηηαξα θαη επνκέλσο εθθξάδνληαη θαη ζε κε θαξθηληθά θχηηαξα πνπ δηαηξνχληαη, φπσο γηα παξάδεηγκα ηα θχηηαξα πνπ ππφθεηληαη ζε δηαδηθαζίεο αλαγέλλεζεο, κεηά απφ ηξαπκαηηζκφ, γεγνλφο πνπ κπνξεί λα πξνθαιέζεη ζχγρπζε ζηηο πξνζπάζεηεο γηα πξψηκε δηάγλσζε. Έλαο βηνδείθηεο ζα πξέπεη λα πιεξεί ζπγθεθξηκέλεο πξνυπνζέζεηο γηα λα είλαη ιεηηνπξγηθφο [49] θαη ηα ηειεπηαία ρξφληα πνιιέο επηζθνπήζεηο αλαθέξνληαη ζην δήηεκα ησλ βηνδεηθηψλ ζηνλ θαξθίλν ηνπ πλεχκνλα θαη ηελ πηζαλή θιηληθή ηνπο ρξήζε [41,42,[50][51][52].…”

Section: α14 βηνδείθηεο ζηνλ θαξθίλν ηνπ πλεύκνλαunclassified

“…Δπίζεοκειεηψληαη ζηνηρεία απφ ηα θπθινθνξνχληα λνπθιετθά νμέα ζην αίκα, φπσο ην ζπλνιηθφ DNA, κεηαιιάμεηο γνληδίσλ, κηθξνδνξπθνξηθέο ηξνπνπνηήζεηο θαη εληφπηζε κεζπιησκέλσλ πεξηνρψλ ησλ ππνθηλεηψλ γνληδίσλ, θαζψο θαη ε εληφπηζε ζπγθεθξηκέλσλ RNA ζην πιάζκα ηνπ αίκαηνο (πρ. hnRNP B1, Her2/neu)[52]. δείγκαηα ηζηνχ απφ πλεχκνλα θαη 76 δείγκαηα κε αδελνθαξθίλσκα[59].…”

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Μελέτη του βιολογικού ρόλου πρωτεϊνών με ικανότητα πρόσδεσης hnRNA και mRNA καθώς και των μηχανισμών της απορύθμισης τους στον ανθρώπινο καρκίνο του πνεύμονα

Μπουκάκης¹

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Clinical biomarkers for cancer recognition and prevention: A novel approach with optical measurements

Latini

Felice

Barducci³

et al. 2018

CBM

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Cancer is the most important cause of death worldwide, and early cancer detection is the most fundamental factor for efficacy of treatment, prognosis, and increasing survival rate. Over the years great effort has been devoted to discovering and testing new biomarkers that can improve its diagnosis, especially at an early stage. Here we report the potential usefulness of new, easily applicable, non-invasive and relatively low-cost clinical biomarkers, based on abnormalities of oral mucosa spectral reflectance and fractal geometry of the vascular networks in several different tissues, for identification of hereditary non-polyposis colorectal cancer carriers as well for detection of other tumors, even at an early stage. In the near future the methodology/technology of these procedures should be improved, thus making possible their applicability worldwide as screening tools for early recognition and prevention of cancer.

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Early Detection of Lung Cancer: A Call for Novel Biomarkers-Review

Cited by 3 publications

References 47 publications

Imaging mass spectrometry: Towards clinical diagnostics

Imaging mass spectrometry: Towards clinical diagnostics

Μελέτη του βιολογικού ρόλου πρωτεϊνών με ικανότητα πρόσδεσης hnRNA και mRNA καθώς και των μηχανισμών της απορύθμισης τους στον ανθρώπινο καρκίνο του πνεύμονα

Clinical biomarkers for cancer recognition and prevention: A novel approach with optical measurements

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