Early detection of gastric cancer in China: progress and opportunities

Xu, Hengmin; Li, Wenqing

doi:10.20892/j.issn.2095-3941.2022.0655

Cited by 17 publications

(20 citation statements)

References 32 publications

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“…Currently, gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer mortality worldwide, contributing to approximately 723,000 deaths annually 1 . Eastern Asia, particularly China, has a substantial GC burden 2 , 3 . In 2020, 44.0% of global GC incidence and 48.6% of global GC-related deaths occurred in China.…”

Section: Introductionmentioning

confidence: 99%

Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods

Zhang,

Yang,

Zhang

et al. 2023

Cancer Biol Med

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Gastric cancer (GC), the fifth most common cancer globally, remains the leading cause of cancer deaths worldwide. Inflammation-induced tumorigenesis is the predominant process in GC development; therefore, systematic research in this area should improve understanding of the biological mechanisms that initiate GC development and promote cancer hallmarks. Here, we summarize biological knowledge regarding gastric inflammation-induced tumorigenesis, and characterize the multi-omics data and systems biology methods for investigating GC development. Of note, we highlight pioneering studies in multi-omics data and state-of-the-art network-based algorithms used for dissecting the features of gastric inflammation-induced tumorigenesis, and we propose translational applications in early GC warning biomarkers and precise treatment strategies. This review offers integrative insights for GC research, with the goal of paving the way to novel paradigms for GC precision oncology and prevention.

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Section: Introductionmentioning

confidence: 99%

Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods

Zhang,

Yang,

Zhang

et al. 2023

Cancer Biol Med

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“…The incidence varies globally, especially high in East Asia and east Europe. Data from published literature 1 - 5 .…”

Section: Figurementioning

confidence: 99%

“…In Japan and Korea, over 50% of cases are detected early, while in Western countries such as the United States, the rate is only approximately 20% 4 . In China, although its incidence accounts for 44.21% of the total number of cases worldwide, the rate of early gastric cancer detection is nearly 10~20% 3 , 5 . Early gastric cancer typically lacks clear symptoms.…”

Section: Introductionmentioning

confidence: 99%

Global progress and future prospects of early gastric cancer screening

Huang,

Shao,

et al. 2024

J. Cancer

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Gastric cancer is a prevalent malignancy that poses a serious threat to global health. Despite advances in medical technologies, screening methods, and public awareness, gastric cancer remains a significant cause of morbidity and mortality worldwide. Early gastric cancer frequently does not present with characteristic symptoms, while advanced stage disease is characterized by a dismal prognosis. As such, early screening in gastric cancer is of great importance. In recent years, advances have been made globally in both clinical and basic research for the screening of early gastric cancer. The current predominant screening methods for early gastric cancer include imaging screening, endoscopic screening and serum biomarker screening. Imaging screening encompasses upper gastrointestinal barium meal, multidimensional spiral computed tomography (MDCT), Magnetic resonance imaging (MRI), and ultrasonography. Endoscopic screening methods include white light endoscopy, chromoendoscopy, computed virtual chromoendoscopy, and other endoscopic techniques like endocytoscopy, confocal laser endomicroscopy, optical coherence tomography and so on. Biomarkers screening involves the assessment of conventional biomarkers such as CEA, CA19-9 and CA72-4 as well as more emerging biomarkers such as peptides (PG, G-17, GCAA, TAAs and others), DNA (cfDNA, DNA methylation, MSI), noncoding RNA (miRNA, lncRNA, circRNA, and tsRNA) and others. Each screening method has its strengths and limitations. This article systematically summarizes worldwide progress and future development of early gastric cancer screening methods to provide new perspectives and approaches for early diagnostic and treatment advancements in gastric cancer worldwide.

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“…In China, scientific pilot study related to GC screening lags behind that of EC screening. The Peking University Cancer Hospital initiated a pilot population-based program for the early diagnosis and treatment of GC in Linqiu County, Shandong Province, a high-incidence area in China, in 1983 33 . The regional GC screening program began in 2005 in rural areas.…”

Section: Gcmentioning

confidence: 99%

Reducing the global cancer burden with gastrointestinal screening: China’s 30 years practice

Yang,

Feng,

Zhu

et al. 2024

Cancer Biol Med

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Early detection of gastric cancer in China: progress and opportunities

Cited by 17 publications

References 32 publications

Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods

Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods

Global progress and future prospects of early gastric cancer screening

Reducing the global cancer burden with gastrointestinal screening: China’s 30 years practice

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