Early detection of cutaneous angiosarcoma of the face and scalp and treatment with placitaxel

Pestoni, C.; Paredes-Suárez, Carmen; Peteiro, C.; Toribio, Jaime

doi:10.1111/j.1468-3083.2004.01139.x

Cited by 28 publications

(25 citation statements)

References 18 publications

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“…Skin and superficial soft tissue are the most common locations (60% of cases) [2] with high rate of lymph node and systemic metastasis and reported 5-year survival of 10% to 35% [3]. …”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma Mimicking Rhinophyma

Presti

Mazzella

Monfrecola

et al. 2010

Dermatology Research and Practice

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We report the case of a 61-year-old man showing persistent erythematous macules, plaques, and partially confluent nodules with irregular borders, developed on his nose for one year. During that time the patient underwent several dermatological consultations, and all produced the same diagnosis: rhinophyma. So antibiotic and steroid treatment was carried out without any improvement while the lesions kept growing. When the patient came to our observation, physical examination revealed large, infiltrative, oedematous, erythematous plaques and rare nodules, with superficial telangiectatic vessels. Cervical lymphadenopathy was not detectable. Routine laboratory analysis was normal. Punch biopsy was performed, and histopathology and immunohistochemical studies were consistent with cutaneous angiosarcoma. This is the report of a face angiosarcoma with an unusual and very deceptive clinical presentation.

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“…Skin and superficial soft tissue are the most common locations (60% of cases) [2] with high rate of lymph node and systemic metastasis and reported 5-year survival of 10% to 35% [3]. …”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma Mimicking Rhinophyma

Presti

Mazzella

Monfrecola

et al. 2010

Dermatology Research and Practice

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“…In most of the cases, treatment is administered on a weekly basis and affects scalp or skin AS. In that setting, most of the reports describe complete or partial responses with short progressionfree survival up to 3-4 months [17][18][19][20][21][22][23]. Angiosarcoma of liver [11] Particularly frequent in industrial workers exposed to vinyl chloride (used in the production of synthetic rubber) Frequent in workers exposed to insecticides, such as arsenics Primaries arose from viscera in 8 cases; from breast in 10 cases; and from soft tissue, skin or, scalp in 12 cases.…”

Section: Treatment Of Metastatic Angiosarcomasmentioning

confidence: 99%

“…Numerous case reports suggest some kind of clinical benefit with paclitaxel [17][18][19] or docetaxel [20][21][22][23] in patients with unresectable or metastatic AS. In most of the cases, treatment is administered on a weekly basis and affects scalp or skin AS.…”

Section: Treatment Of Metastatic Angiosarcomasmentioning

confidence: 99%

Angiosarcomas and Taxanes

Penel

Lansiaux

Adenis

2007

Curr. Treat. Options in Oncol.

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Angiosarcomas (AS) are a heterogeneous group of rare and aggressive malignancies. The best treatment of localized AS includes wide resection following by adjuvant radiation therapy as possible. The current standard treatment of metastatic AS remains a doxorubicin-based regimen. This treatment provides a median progression-free survival and a median overall survival of about 4 and 8 months, respectively. Numerous case reports and retrospective studies have suggested that taxanes (paclitaxel or docetaxel) may provide some objective responses. The French Sarcoma Group has conducted a phase II clinical trial, which states the benefit of weekly paclitaxel in patients with unresectable or metastatic AS. After 2 cycles, the non-progression rate was 78% and complete histological responses were observed in 3 out of 30 cases. Further clinical studies are needed to confirm clinic impact of weekly paclitaxel on survival and to assess the role of taxanes in the multidisciplinary treatment of AS.

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“…In most of the cases reported taxanes were given once weekly and led to complete or partial responses with short progression-free survival up to 3-4 months. 3,8,9 Recently, a phase II clinical trial was conducted, which showed the benefit of weekly paclitaxel in 30 patients with unresectable or metastatic AS. In agreement with previous studies the authors reported a median time to progression of 4 months and a median overall survival of 8 months.…”

mentioning

confidence: 99%

Major response to paclitaxel combined with irradiation as second-line therapy in metastatic angiosarcoma of the face and scalp

Hofmann¹,

Wobser²,

Kneitz³

et al. 2009

British Journal of Dermatology

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Trichofolliculoma has been shown positive for K15 and K16, suggesting differentiation to the outer root sheath and the hair bulge. 8 The present results strongly support the concept of Kimura et al. 1 that FSCH is distinct from sebaceous trichofolliculoma as it is devoid of prominent differentiation towards the hair follicles. Trichoadenoma has been shown positive for K15 and K17, suggesting differentiation towards the infundibulum and the hair bulge. 9 In trichilemmoma, the tumour was shown to express K15, K16 and K17, suggesting that it differentiates towards the infundibulum, the outer root sheath, the hair bulge and the sebaceous gland. 6 In summary, in FSCH, keratin expression in each of the epithelial components, including the infundibular cystic-like structure, sebaceous duct-like structure and sebaceous celllike structure, was almost identical to that in the normal pilosebaceous unit. Based on the expression of keratin and filaggrin, FSCH differentiates toward the follicular infundibulum, sebaceous duct and sebaceous cells. These findings help to distinguish FSCH from other tumours of hair appendages. Kusumoto K et al. Trichofolliculoma: case report with immunohistochemical study of cytokeratins. Br J Dermatol 2003; 148:597-8. 9 Kurokawa I, Mizutani H, Nishijima S et al. Trichoadenoma: cytokeratin expression suggesting differentiation towards the follicular infundibulum and follicular bulge regions. Br J Dermatol 2005; 153:1084-6.

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Early detection of cutaneous angiosarcoma of the face and scalp and treatment with placitaxel

Cited by 28 publications

References 18 publications

Angiosarcoma Mimicking Rhinophyma

Angiosarcoma Mimicking Rhinophyma

Angiosarcomas and Taxanes

Major response to paclitaxel combined with irradiation as second-line therapy in metastatic angiosarcoma of the face and scalp

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