Early detection of cardiac dysfunction: Use of the myocardial performance index in patients with anorexia nervosa

An Echocardiographic Study of Left Ventricular Size and Cardiac Function in Adolescent Females with Anorexia Nervosa

“…The LV dimensions, LV wall thickness, LVM and LA dimension were significantly decreased in patients with AN, which has also been noted in previous studies (de Simone et al, ; Eidem et al, ; Galetta et al, ; Galetta et al, ; Kastner et al, ; Lelli et al, ; Romano et al, ; St John Sutton et al, ; Vazquez et al, ). Mean LVM was reduced by approximately 20–25% in the AN and AN ≤ 10th groups.…”

“…Despite decreased LVM and LV dimensions, resting systolic function in AN patients was unchanged. The majority of studies concerning systolic function in AN have demonstrated no differences in ejection fraction, FS or MVCFc (de Simone et al, ; DiVasta et al, ; Eidem et al, ; Galetta et al, ; Galetta et al, ; Kastner et al, ; St John Sutton et al, ; Vazquez et al, ). We found that patients with AN and controls had similar MVCFc; however, MVCFc is affected by LV afterload (or BP), and patients with AN have a significantly lower BP (de Simone et al, ; Galetta et al, ; Galetta et al, ; Romano et al, ; St John Sutton et al, ).…”

“…Despite reduced LV dimensions and mass, ventricular systolic function in AN, as measured by the standard indices of ejection fraction and fractional shortening, has been shown not to differ when compared with that in female controls (de Simone et al, ; Eidem et al, ; Galetta et al, ; Galetta et al, ; Kastner et al, ; St John Sutton et al, ; Vazquez et al, ). However, studies of systolic tissue Doppler indices and the myocardial performance index have suggested that there may be subtle decreases in systolic function in women with AN (Eidem et al, ; Galetta et al, ). Fewer studies have investigated diastolic function, or the ability of the heart to appropriately fill with blood, in AN and these studies have demonstrated conflicting results.…”

“…While transmitral Doppler indices of diastolic function including transmitral A wave velocities and E/A ratios have been shown to be different in patients with AN, other measures of diastolic function including tissue Doppler have not shown differences (de Simone et al, ; Galetta et al, ; Galetta et al, ). The majority of these studies have, however, been performed on relatively small numbers of patients and in adult populations (de Simone et al, ; Eidem et al, ; Galetta et al, ; Galetta et al, ; Romano et al, ; St John Sutton et al, ; Vazquez et al, ).…”

Evaluation of the myocardial performance index and tissue doppler imaging by comparison to near-simultaneous catheter measurements in pediatric cardiac transplant patients

“…8,9 It has also been shown to be different in populations at risk for myocardial dysfunction (patients with anorexia and those exposed to anthracyclines) as compared with controls. 10,11 Interestingly, this statistical difference held true only for the left ventricle. In another study involving patients exposed to anthracyclines, MPI inversely correlated with performance in cardiopulmonary testing.…”