Early detection and prognosis evaluation for hepatocellular carcinoma by circulating tumour DNA methylation: A multicentre cohort study
De‐Zhen Guo,
Ao Huang,
Ying‐Chao Wang
et al.
Abstract:BackgroundEarly diagnosis of hepatocellular carcinoma (HCC) can significantly improve patient survival. We aimed to develop a blood‐based assay to aid in the diagnosis, detection and prognostic evaluation of HCC.MethodsA three‐phase multicentre study was conducted to screen, optimise and validate HCC‐specific differentially methylated regions (DMRs) using next‐generation sequencing and quantitative methylation‐specific PCR (qMSP).ResultsGenome‐wide methylation profiling was conducted to identify DMRs distingui… Show more
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