Early Dementia Screening

Panegyres, Peter K.; Berry, Renee; Burchell, Jennifer

doi:10.3390/diagnostics6010006

Cited by 67 publications

(58 citation statements)

References 66 publications

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“…Additionally, new Positron Emission Tomography (PET) imaging techniques are now capable of detecting AD-relevant molecular changes, including the hallmark pathologies of amyloid-β plaques and neurofibrillary tangles, making it likely these imaging techniques will play an important role in future efforts to detect and diagnose the disease [3]. Three radiopharmaceuticals are currently FDA-approved to detect amyloid-β plaques (florbetapir, flutemetamol, and florbetaben) and new compounds targeting other features of the disease, such as tau, are expected to reach market in the near future [4, 5]. …”

Section: Introductionmentioning

confidence: 99%

Augmenting Amyloid PET Interpretations With Quantitative Information Improves Consistency of Early Amyloid Detection

Harn

Hunt²,

Hill³

et al. 2017

Clinical Nuclear Medicine

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Purpose Establishing reliable methods for interpreting elevated cerebral amyloid-β plaque on PET scans is increasingly important for radiologists, as availability of PET imaging in clinical practice increases. We examined a three-step method to detect plaque in cognitively normal older adults, focusing on the additive value of quantitative information during the PET scan interpretation process. Methods Fifty-five F-18 florbetapir PET scans were evaluated by three experienced raters. Scans were first visually interpreted as having “elevated” or “non-elevated” plaque burden (“Visual Read”). Images were then processed using a standardized quantitative analysis software (MIMneuro) to generate whole brain and region of interest (ROI) standard uptake value ratios (SUVRs). This “Quantitative Read” was considered elevated if at least two of six ROIs had an SUVR >1.1. The final interpretation combined both visual and quantitative data together (“VisQ Read”). Cohen’s kappa values were assessed as a measure of interpretation agreement. Results Plaque was elevated in 25.5–29.1% of the 165 total Visual Reads. Inter-rater agreement was strong (Kappa=0.73–0.82) and consistent with reported values. Quantitative Reads were elevated in 45.5% of participants. Final VisQ Reads changed from initial Visual Reads in 16 (9.7%) interpretations, with most changing from “non-elevated” Visual Reads to “elevated.” These changed interpretations demonstrated lower plaque quantification than those initially read as “elevated” that remained unchanged. Inter-rater variability improved for VisQ Reads with the addition of quantitative information (Kappa=0.88–0.96). Conclusion Inclusion of quantitative information increases consistency of PET scan interpretations for early detection of cerebral amyloid-β plaque accumulation.

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Section: Introductionmentioning

confidence: 99%

Augmenting Amyloid PET Interpretations With Quantitative Information Improves Consistency of Early Amyloid Detection

Harn

Hunt²,

Hill³

et al. 2017

Clinical Nuclear Medicine

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“…Early dementia screening by a primary care physician should be completed once a patient or a knowledgeable informant has noticed decline in memory or difficulty [2]. Screening is not indicated at the general population level [3,4], because currently there are no specific treatments to block the progression of cognitive decline in AD and other neurocognitive dementias.…”

Section: Alzheimer's Disease: Public Health Prioritymentioning

confidence: 99%

“…The modalities of telecare can be very diverse, and the telemedicine projects of attention to users with dementia performed include [1] support for patients so that they can continue to live independently; [2] support services for informal caregivers through "online" training, video conferencing with professionals, telealarm with videoconference, and cognitive stimulation; [3] networks for patient and caregivers; [4] monitoring of the state of the patient, personalized intervention, and adaptive care; [5] platform that integrates smart home technologies, with sensors and interoperability with professionals and institutions; and [6] computer programs to caregivers to improve their overload, mainly emotional.…”

Section: Social Sanitary Assistance Management Toolsmentioning

confidence: 99%

“…The guiding principles of the assistance in the unit of memory are [1] universality and equality; [2] integrality and transversality, with coordination of all the members; and [3] efficiency and sustainability. This unit must be endowed with the human and material resources to meet its objectives [41,42].…”

Section: Health Model Units Of Cognitive Disorder and Conductmentioning

confidence: 99%

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Healthcare Models in Alzheimer’s Disease

Garzón-Maldonado¹,

Torres²

2019

Redirecting Alzheimer Strategy - Tracing Memory Loss to Self Pathology

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Alzheimer's disease is currently a health care problem and in the future, when we have effective treatments, it will become a public health priority. Health systems should adapt to this situation. New technologies are tools that can improve healthcare and lower costs. The mobile phone with call o video call conference is going to suppose a radical change in the control of these patients. The telephone assistance to patient or relatives is very satisfactory for both due to the rapidity in the response to their problem and the comfort with which they are attended to. Also the health system reduces the costs of face-to-face consultation. In addition, this telemedicine could be applied for cognitive stimulation, with specific programs for each patient and for the follow-up of patients in their homes, delaying their entry into residences. The objective is to turn the patients and their caregiver into cotherapists together with the nurse and the physician, in the follow-up of Alzheimer's disease.

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“…5 Paralelamente, o diagnóstico precoce é especialmente importante numa altura em que se investe nas terapias modificadoras da doença, em que o tratamento possa influenciar o curso natural da doença. 7 Além disso, permite ativar atempadamente os apoios da comunidade e reduzir a morbilidade psicológica sentida pelos cuidadores. 8 Com este trabalho pretende-se conhecer as características da referenciação dos CSP à consulta de memória do serviço de neurologia do Hospital de Braga, a fim de se potenciar e melhorar a articulação entre diferentes níveis dos cuidados de saúde.…”

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