Early cytological diagnosis of diffuse malignant mesothelioma of the peritoneum: A case report

Pomjanski, M.I.A.C. Natalia; Grote, Monika; Sander, Oliver; Heikaus, Sebastian; Müller, Klaus‐Michael; M.D., F.I.A.C. Alfred Böcking

doi:10.1002/dc.20759

Cited by 8 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The only truly useful tool for MM diagnosis at this stage is cytology. 5 The cytological characteristics of MM have been well described. 6,7 Results from laboratories with significant MM experience have reported that the predictive value for a positive MM diagnosis in serous effusions is 100% in their hands.…”

mentioning

confidence: 99%

Scoring system for differential diagnosis of malignant mesothelioma and reactive mesothelial cells on cytology specimens

Kimura

Dota

Araya

et al. 2009

Diagnostic Cytopathology

View full text Add to dashboard Cite

Cytology is the only useful tool in the detection of malignant mesothelioma (MM) at an early stage. No other methods, such as immunocytochemistry or electron microscopy, are available to distinguish MM from reactive mesothelial cells (RMC). Some objective analysis of cytology specimens is necessary. On the basis of our case review and cytological features described in previous articles, we developed a scoring system for malignant mesothelioma (SSMM) of effusion cytology to distinguish MM cells from RMC. Mesothelioma cells in effusions from 22 patients (20 pleural and 2 peritoneal mesotheliomas) were compared with RMC from 20 patients without obvious tumor cells and 50 effusions containing metastatic carcinoma cells. The SSMM is based on characteristic features of mesothelial and malignant cells. The total achievable score is 10 points: one point each is given for variety of cell size, cyanophilic cytoplasm with villosity/windows/bleb, sheet-like arrangement, mirror-ball-like cell clusters, nuclear atypia, and cannibalism, respectively. Further two points each are ascribed for acidophilic large nucleoli and multinucleated cells with more than eight nuclei. The total score for each of the 22 mesotheliomas was more than 5 points. On the other hand, all RMC and the 50 metastatic carcinoma cases scored less than 3 points, aside from two cases that were treated with OK432. No single characteristic feature was observed to be consistent within the 22 mesotheliomas analyzed. Ancillary use of immunocytochemistry, such as podoplanin (D2-40) and calretinin, supported the diagnostic accuracy of the SSMM. SSMM is useful for the differential diagnosis of MM.

show abstract

mentioning

confidence: 99%

Scoring system for differential diagnosis of malignant mesothelioma and reactive mesothelial cells on cytology specimens

Kimura

Dota

Araya

et al. 2009

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…Cytological examination of ascitic fluid removed by paracentesis rarely results in a positive finding [8]. According to the data review of previous case reports and the current case of DMPM [9–12], the sensitivity of ascitic fluid cytology in the diagnosis of malignant mesothelioma was 54% (7/13). In clinical practice, ascitic fluid cytology can be used as an initial diagnostic modality for malignant mesothelioma.…”

Section: Discussionmentioning

confidence: 85%

Diffuse malignant peritoneal mesothelioma

Shih

Tsay

et al. 2013

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

Mesothelioma often originates in the pleura and less frequently in the peritoneum. This article describes a rare case of diffuse malignant peritoneal mesothelioma in a 54-year-old male construction worker who was admitted to our hospital with a 2-month history of progressive abdominal distention. Abdominal computed tomography revealed extensive peritoneal nodularity and omental cake along with massive ascites. Imaging findings initially suggested peritoneal carcinomatosis, primary peritoneal carcinoma, and tuberculous peritonitis. Laparoscopic biopsy of the omentum and peritoneum confirmed the diagnosis of malignant peritoneal mesothelioma of epitheloid type. Although systemic chemotherapy was administered, no tumor regression was found. The patient finally died of nosocomial infection.

show abstract

“…Appropriate panel of immunohistochemical (IHC) markers and electron microscopy (EM) are useful in substantiating the diagnosis. [1][2][3] Herein, we present an uncommon case study of a diffuse peritoneal mesothelioma, which was labeled as an adenocarcinoma on ascitic fluid examination and on biopsy, which is based on the presence of ''signet-ring'' cells. Only rarely such cases have been identified.…”

mentioning

confidence: 99%

“Signet‐ring” cells—A caveat in the diagnosis of a diffuse peritoneal mesothelioma occurring in a lady presenting with recurrent ascites: An unusual case report

Rekhi¹,

Pathuthara²,

Ajit³

et al. 2009

Diagnostic Cytopathology

View full text Add to dashboard Cite

A diffuse peritoneal mesothelioma is a rare tumor. Exfoliative cytology forms the first step in the diagnosis of mesothelioma, since most of these cases presented with effusion. Despite well established cytomorphological features, a challenge exists in differentiating mesothelial cells, including reactive and malignant types from carcinoma cells and macrophages. Presence of "signet-ring" cells increases the diagnostic challenge as these can be forms of benign and malignant cells. Ancillary techniques like immunohistochemical (IHC) markers and ultrastructural analysis form useful adjunct in substantiating exact diagnosis. We report an unusual case study of a diffuse peritoneal mesothelioma in a 57-years-old lady, with no history of asbestos exposure, presenting with recurrent ascites, diagnosed on ascitic fluid cytology and on histology as an adenocarcinoma, based upon the presence of "signet-ring" cells. On review, clinicopathological correlation with IHC was helpful in forming correct diagnosis.

show abstract

Early cytological diagnosis of diffuse malignant mesothelioma of the peritoneum: A case report

Cited by 8 publications

References 22 publications

Scoring system for differential diagnosis of malignant mesothelioma and reactive mesothelial cells on cytology specimens

Scoring system for differential diagnosis of malignant mesothelioma and reactive mesothelial cells on cytology specimens

Diffuse malignant peritoneal mesothelioma

“Signet‐ring” cells—A caveat in the diagnosis of a diffuse peritoneal mesothelioma occurring in a lady presenting with recurrent ascites: An unusual case report

Contact Info

Product

Resources

About