Early contrast enhancement of the liver: exact description of subphases using MRI

Neto, José Aloizio Gonçalves; Altun, Ersan; Vaidean, Georgeta; El‐Azzazi, Mohamed; Troy, Jeffrey; Ramachandran, Sudha; Semelka, Richard C.

doi:10.1016/j.mri.2008.11.003

Cited by 22 publications

(6 citation statements)

References 22 publications

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“…As part of our standard abdominal MRI protocol, the following sequences were performed: axial unenhanced twodimensional (2D) gradient-echo T1-weighted dual-echo inphase (repetition time/echo time [TR/TE] of 125/4.3 ms, 80° flip angle) and out-of-phase (125/2.1, 80° flip angle); coronal half-Fourier single-shot fast spin-echo T2-weighted (TR/TE of 1894.7/83.9 ms); axial half-Fourier single-shot fast spin-echo T2-weighted (TR/TE of 1800/89.9 ms), with and without fat suppression; and axial pre- and post-gadolinium fat-suppressed 3D gradient-echo (TR/TE of 4.17/1.98 ms, 12° flip angle) during the late arterial (also known as the hepatic arterial-dominant), portal venous, and interstitial phases (19) .…”

Section: Methodsmentioning

confidence: 99%

Modified approach to the characterization of adrenal nodules using a standard abdominal magnetic resonance imaging protocol

et al. 2017

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ObjectiveTo describe a modified approach to the evaluation of adrenal nodules using a standard abdominal magnetic resonance imaging protocol.Materials and MethodsOur sample comprised 149 subjects (collectively presenting with 132 adenomas and 40 nonadenomas). The adrenal signal intensity index was calculated. Lesions were grouped by pattern of enhancement (PE), according to the phase during which the wash-in peaked: arterial phase (type 1 PE); portal venous phase (type 2 PE); and interstitial phase (type 3 PE). The relative and absolute wash-out values were calculated. To test for mean differences between adenomas and nonadenomas, Student's t-tests were used. Receiver operating characteristic curve analysis was also performed.ResultsThe mean adrenal signal intensity index was significantly higher for the adenomas than for the nonadenomas (p < 0.0001). Chemical shift imaging showed a sensitivity and specificity of 94.4% and 100%, respectively, for differentiating adenomas from nonadenomas. Of the adenomas, 47.6%, 48.5%, and 3.9%, respectively, exhibited type 1, 2, and 3 PEs. For the mean wash-in proportions, significant differences were found among the enhancement patterns. The wash-out calculations revealed a trend toward better lesion differentiation for lesions exhibiting a type 1 PE, showing a sensitivity and specificity of 71.4% and 80.0%, respectively, when the absolute values were referenced, as well as for lesions exhibiting a type 2 PE, showing a sensitivity and specificity of 68.0% and 100%, respectively, when the relative values were referenced. The calculated probability of a lipid-poor lesion that exhibited a type 3 PE being a nonadenoma was > 99%.ConclusionSubgrouping dynamic enhancement patterns yields high diagnostic accuracy in differentiating adenomas from nonadenomas.

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Section: Methodsmentioning

confidence: 99%

Modified approach to the characterization of adrenal nodules using a standard abdominal magnetic resonance imaging protocol

et al. 2017

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“…However, one disadvantage of conventional radial 3D-GRE is that data acquisition takes approximately 1.5 min. This precludes acquisition of dynamically acquired post-contrast images, specifically the arterial phase (9–11) which may represent one of the most clinically important datasets in liver imaging, especially for the detection and characterization of hypervascular nodules (9,10).…”

Section: Introductionmentioning

confidence: 99%

Surrogate arterial phase imaging using a long duration (≈1.5 min) radial acquisition T1-weighted sequence: an alternative in patients unable to breath-hold

et al. 2015

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“…As liver diseases can affect the vasculature heterogeneously, the optimal timing may also vary with patients and lesions. This indicates that dynamic 3D contrast enhanced magnetic resonance imaging exam should further resolve the arterial phase into multiple subphases for accurate diagnosis of liver lesions (9). Even with parallel imaging, a typical 3D acquisition with adequate spatial resolution is more than 10 s, which is not adequate for resolving arterial subphases.…”

Section: Introductionmentioning

confidence: 99%

Fast 3D contrast enhanced MRI of the liver using temporal resolution acceleration with constrained evolution reconstruction

Spincemaille

Chen

et al. 2012

Magnetic Resonance in Med

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Time-resolved imaging is crucial for the accurate diagnosis of liver lesions. Current contrast enhanced liver magnetic resonance imaging acquires a few phases in sequential breath-holds. The image quality is susceptible to bolus timing errors, which could result in missing the critical arterial phase. This impairs the detection of malignant tumors that are supplied primarily by the hepatic artery. In addition, the temporal resolution may be too low to reliably separate the arterial phase from the portal venous phase. In this study, a method called temporal resolution acceleration with constrained evolution reconstruction was developed with three-dimensional volume coverage and high-temporal frame rate. Data is acquired using a stack of spirals sampling trajectory combined with a golden ratio view order using an eight-channel coil array. Temporal frames are reconstructed from vastly undersampled data sets using a nonlinear inverse algorithm assuming that the temporal changes are small at short time intervals. Numerical and phantom experimental validation is presented. Preliminary in vivo results demonstrated high spatial resolution dynamic three-dimensional images of the whole liver with high frame rates, from which numerous subarterial phases could be easily identified retrospectively.

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Early contrast enhancement of the liver: exact description of subphases using MRI

Cited by 22 publications

References 22 publications

Modified approach to the characterization of adrenal nodules using a standard abdominal magnetic resonance imaging protocol

Modified approach to the characterization of adrenal nodules using a standard abdominal magnetic resonance imaging protocol

Surrogate arterial phase imaging using a long duration (≈1.5 min) radial acquisition T1-weighted sequence: an alternative in patients unable to breath-hold

Fast 3D contrast enhanced MRI of the liver using temporal resolution acceleration with constrained evolution reconstruction

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