Early complete remitters after electroconvulsive therapy: profile and prognosis

Spaans, Harm-Pieter; Verwijk, Esmée; Stek, Max L.; Kho, King H.; Boeckaert, F.; Kok, Rob M.; Sienaert, Pascal

doi:10.1016/j.brs.2017.01.138

Cited by 2 publications

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“…This is consistent with other studies assessing MoCA scores as a primary outcome among older adults receiving ECT for depression 25 . Another study of ECT response predictors found that lower baseline cognitive performance was found in ECT remitters 26 . Improvement in test scores highlights the reversible cognitive impact of the depression itself.…”

Section: Discussionsupporting

confidence: 88%

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Electroconvulsive Therapy for Unipolar Depression in Older Adults

Morcos

Strominger

2022

J ECT

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Objectives: Electroconvulsive therapy (ECT) is a safe and effective procedure in unipolar depression in older adults; however, less is known about clinical features and trajectories among patients who do not respond. In this retrospective, naturalistic study, we examine characteristics associated with ECT response among older adults with unipolar depression who received ECT over an 8-year period and describe long-term outcomes for nonresponders. Methods:We retrospectively identified patients 65 years or older with major depressive disorder who were treated with ECT during an 8-year period. We reviewed demographic and clinical factors among patients who responded to ECT and those who did not. Clinic notes were reviewed for ECT nonresponders to determine Clinical Global Impressions scores in the 24 months after ECT treatment. Results:We identified 140 patients meeting the inclusion criteria. Most patients (65%) responded to ECT. Fewer previous antidepressant trials, lower baseline Montreal Cognitive Assessment scores, and lower baseline Montgomery-Asberg Depression Rating Scale scores were associated with an increased likelihood of ECT response. Among the 49 (35%) nonresponders, another 12 (24.5%) responded to a variety of treatments within 2 years after ECT. There were no serious adverse effects of treatment.Conclusions: Most patients responded to ECT, many of whom had severe illness that had been refractory to numerous medication trials. Among nonresponders, a subset improved over time through a variety of treatments. However, most patients who did not respond to ECT had persistent depression after 2 years.

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Section: Discussionsupporting

confidence: 88%

“…25 Another study of ECT response predictors found that lower baseline cognitive performance was found in ECT remitters. 26 For number of previous antidepressant trials, the N was 138; for duration of current depressive episode, the N was 137; for MoCA, the N was 135; and for MADRS, the N was 92. N was 140 in all other analyses.…”

Section: Discussionmentioning

confidence: 99%

Electroconvulsive Therapy for Unipolar Depression in Older Adults

Morcos

Strominger

2022

J ECT

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“…Furthermore, ECT has a very fast antidepressant effect, a significant improvement in depressive symptomatology may be observed after two ECT sessions (9). In a recent study with older depressed patients, a substantial number of patients (24%) that attained full remission did so within 4 ECT sessions (15).…”

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confidence: 99%

Electroconvulsive therapy: we are hesitant to use the most effective treatment for severe depression

Birkenhäger

Diermen

2020

Acta Psychiatr Scand

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Early complete remitters after electroconvulsive therapy: profile and prognosis

Cited by 2 publications

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Electroconvulsive Therapy for Unipolar Depression in Older Adults

Electroconvulsive Therapy for Unipolar Depression in Older Adults

Electroconvulsive therapy: we are hesitant to use the most effective treatment for severe depression

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