Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*

Kumar, Anand; Zarychanski, Ryan; Light, Bruce; Parrillo, Joseph E.; Maki, Dennis G.; Simon, Dave; Laporta, Denny; Lapinsky, Steve; Ellis, Paul; Mirzanejad, Yazdan; Martinka, Greg; Keenan, Sean; Wood, Gordon; Arabi, Yaseen M.; Feinstein, Daniel; Kumar, Aseem; Dodek, Peter; Kravetsky, Laura; Doucette, Steve

doi:10.1097/ccm.0b013e3181eb3ccd

Cited by 404 publications

(254 citation statements)

References 60 publications

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“…[4][5][6] Following such evidence-based protocols and process-of-care interventions has been shown to be associated with better patient outcomes, including decreased mortality. 7,8 Most patients with severe sepsis are cared for in intensive care units (ICUs). At times, there are no beds available in the primary ICU and patients presenting to the hospital with sepsis are cared for in other units.…”

Section: Discussionmentioning

confidence: 99%

Does sepsis treatment differ between primary and overflow intensive care units?

Vishnupriya

Falade

Workneh

et al. 2012

Journal of Hospital Medicine

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BACKGROUND:Sepsis is a major cause of death in hospitalized patients. Early goal‐directed therapy is the standard of care. When primary intensive care units (ICUs) are full, sepsis patients are cared for in overflow ICUs.OBJECTIVE:To determine if process‐of‐care measures in the care of sepsis patients differed between primary and overflow ICUs at our institution.DESIGN:We conducted a retrospective study of all adult patients admitted with sepsis between July 2009 and February 2010 to either the primary ICU or the overflow ICU.MEASUREMENTS:Baseline patient characteristics and multiple process‐of‐care measures, including diagnostic and therapeutic interventions.RESULTS:There were 141 patients admitted with sepsis to our hospital; 100 were cared for in the primary ICU and 41 in the overflow ICU. Baseline acute physiology and chronic health evaluation (APACHE II) scores were similar. Patients received similar processes‐of‐care in the primary ICU and overflow ICU with the exception of deep vein thrombosis (DVT) and gastrointestinal (GI) prophylaxis within 24 hours of admission, which were better adhered to in the primary ICU (74% vs 49%, P = 0.004, and 68% vs 44%, P = 0.012, respectively). There were no significant differences in hospital and ICU length of stay between the 2 units (9.68 days vs 9.73 days, P = 0.98, and 4.78 days vs 4.92 days, P = 0.97, respectively).CONCLUSIONS:Patients with sepsis admitted to the primary ICU and overflow ICU at our institution were managed similarly. Overflowing sepsis patients to non‐primary intensive care units may not affect guideline‐concordant care delivery or length of stay. Journal of Hospital Medicine 2012; © 2012 Society of Hospital Medicine

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Section: Discussionmentioning

confidence: 99%

Does sepsis treatment differ between primary and overflow intensive care units?

Vishnupriya

Falade

Workneh

et al. 2012

Journal of Hospital Medicine

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“…c Typically require dual broad-spectrum antibiotics with overlapping coverage [189][190][191][192]. d In patients with a history of IV drug use, those with indwelling vascular catheters or devices, or those with recent hospitalizations an agent such as daptomycin (in absence of pneumonia) or vancomycin (IF mic ≤1) or linezolid (in absence of bacteremia) should be adopted.…”

Section: Late Onset And/or Risk Factors For Mdr Organismsmentioning

confidence: 99%

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

Mirabile

Numico²,

Russi

et al. 2015

Critical Reviews in Oncology/Hematology

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The reporting of infection/sepsis in chemo/radiation-treated head and neck cancer patients is sparse and the problem is underestimated. A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of infections and sepsis. The Delphi appropriateness method was used for this consensus. External expert reviewers then evaluated the conclusions carefully according to their area of expertise. The paper contains seven clusters of statements about the clinical definition and management of infections and sepsis in head and neck cancer patients, which had a consensus. Furthermore, it offers a review of recent literature in these topics

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“…The published meta-analysis did not stratify for the resistance status as it included mostly studies in the pre-XDR era [49][50][51]. Also, the study by Kumar et al did not focus on XDR P. aeruginosa and does not provide answers to this clinical question [52]. As few therapy options exist for XDR P. aeruginosa [53]-usually colistin, less commonly fosfomycin and aminoglycosides-combination therapy appears to be preferable based on non-clinical data of the abovementioned antibiotics.…”

Section: Use Of Combination Therapymentioning

confidence: 99%

Treatment of extensively drug-resistant Gram-negative infections in critically ill patients: Outcome of a consensus meeting at the 13th Asia-Pacific Congress of Clinical Microbiology and Infection, October 2012

Tambyah

Hara

Daikos

et al. 2013

Journal of Global Antimicrobial Resistance

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Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*

Abstract: Early combination antibiotic therapy is associated with decreased mortality in septic shock. Prospective randomized trials are needed.

Cited by 404 publications

References 60 publications

Does sepsis treatment differ between primary and overflow intensive care units?

Does sepsis treatment differ between primary and overflow intensive care units?

Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus

Treatment of extensively drug-resistant Gram-negative infections in critically ill patients: Outcome of a consensus meeting at the 13th Asia-Pacific Congress of Clinical Microbiology and Infection, October 2012

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