Early Clinical Results of Acth and Cortisone Treatment of Ocular Diseases

Fitzgerald, Judith; Bellows, John G.; Donegan, Justin M.; Gamble, Richard C.; Krause, Arlington C.; Mann, William A.; Pearlman, Maurice D.; Zekman, Theodore N.

doi:10.1001/archopht.1951.01700010326007

Cited by 49 publications

(6 citation statements)

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“…Corticosteroids for the treatment of ocular disease was first described in the early 1950s. [3][4][5][6][7][8] Since that time, the goal of delivering therapeutic levels of corticosteroid to the eye while minimizing systemic exposure has become increasingly achievable. Pharmacokinetic limitations often render topical delivery inadequate for posterior segment diseases, 9,10 whereas subconjunctival, peribulbar, and intravitreal injections typically produce concentrations that are more effective, albeit short-lived and associated with significant side effects.…”

Section: Introductionmentioning

confidence: 99%

The dexamethasone drug delivery system: Indications and evidence

2011

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The dexamethasone DDS is one of the most recent additions to the armamentarium against macular edema, and is intriguing for its potency, dose consistency, potential for extended duration of action, and favorable safety profile. Early evidence shows clinical utility for several conditions, the most well established being for macular edema associated with RVO. Future studies and, in particular, head-to-head comparisons with other treatment modalities will elucidate the precise role for the dexamethasone DDS in clinical practice.

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Section: Introductionmentioning

confidence: 99%

The dexamethasone drug delivery system: Indications and evidence

2011

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“…and cortisone would be expected to be of value in their management, but the literature on the use of these hormones in syphilitic ocular disease is small. Fitzgerald et al (1951) reported rapid improvement (and no relapse after four months' observation) with parenteral cortisone in a case of acute syphilitic granulomatous uveitis. Reports on cases of interstitial keratitis have been made by Woods (1950) Scheie (1951) (three cases, one of which was advanced with the " salmon patch " type of vascularization).…”

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confidence: 92%

“…have been made by Blake et al (1950), Gordon and McLean (1950), Mann and Markson (1950), McLean (1950), andOlson et al (1950); with A.C.T.H. and cortisone by Harvey et al (1950) andWoods (1950) ; and with cortisone by , Henderson and Hollenhorst (1950), Fitzgerald et al (1951), Leopold et al (1951), Olsen et al (1951, Scheie et al (1951), Steffensen et al (1951). and Thygeson and Fritz (1951).…”

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confidence: 99%

Topical Cortisone in Treatment of Syphilitic Ocular Disease

Horne¹

1951

BMJ

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“…were unfavourable. Fitzgerald et al (1951) treated three cases with A.C.T.H., with unfavourable results, and three cases, in the late glaucomatous stage of the disease, with cortisone locally, with results of doubtful significance. On the other hand, the experience of Reese and Blodi (1951a)has encouraged them to continue the use of A.C.T.H.…”

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confidence: 99%