Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding

Sung, Joseph J.Y.; Luo, Derek; Wu, Justin Che Yuen; Ching, Jessica; Chan, Francis K.L.; Lau, James Y.; Mack, Susan; Ducharme, Richard; Okolo, Patrick I.; Canto, Marcia I.; Kalloo, Anthony N.; Giday, Samuel A.

doi:10.1055/s-0030-1256311

Cited by 228 publications

(199 citation statements)

References 3 publications

(4 reference statements)

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“…Of the 19 studies, 6 were case reports [Fujita, 2012;Granata et al 2013;Sargon and Laurie, 2013;Stanley et al 2013;Paganelli et al 2014;Moosavi et al 2013] and 13 were case series. A total of 17 studies studied humans (234 cases) [Sung et al 2011;Chen et al 2012;Fujita et al 2012;Granata et al 2013;Leblanc et al 2013;Ibrahim et al 2013;Smith et al 2013;Sargon and Laurie, 2013;Stanley et al 2013;Soulellis et al 2013;Yau et al 2014;Smith et al 2014;Holster et al 2014;Sulz et al 2014;Paganelli et al 2014;Chen et al 2014;Moosavi et al 2013], while the remaining two performed in the United States involved porcine models (11 cases) [Giday et al 2011[Giday et al , 2013. The mean age of human subjects was 54.9 years.…”

Section: Resultsmentioning

confidence: 99%

“…However, given the relatively low-pressure system used in the canister during deployment of the powder, the risk of embolism is minuscule [Babiuc et al 2013]. Reports of hemostatic powder dislodgement from the gastrointestinal mucosa approximately 48 hours after its use may theoretically cause intestinal obstruction [Sung et al 2011]. However, review of the literature did not reveal any of these potential adverse events.…”

Section: Adverse Events and Limitationsmentioning

confidence: 99%

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Hemostatic powder spray: a new method for managing gastrointestinal bleeding

Changela

Papafragkakis

Ofori

et al. 2015

Therap Adv Gastroenterol

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Gastrointestinal bleeding is a leading cause of morbidity and mortality in the United States. The management of gastrointestinal bleeding is often challenging, depending on its location and severity. To date, widely accepted hemostatic treatment options include injection of epinephrine and tissue adhesives such as cyanoacrylate, ablative therapy with contact modalities such as thermal coagulation with heater probe and bipolar hemostatic forceps, noncontact modalities such as photodynamic therapy and argon plasma coagulation, and mechanical hemostasis with band ligation, endoscopic hemoclips, and over-the-scope clips. These approaches, albeit effective in achieving hemostasis, are associated with a 5-10% rebleeding risk. New simple, effective, universal, and safe methods are needed to address some of the challenges posed by the current endoscopic hemostatic techniques. The use of a novel hemostatic powder spray appears to be effective and safe in controlling upper and lower gastrointestinal bleeding. Although initial reports of hemostatic powder spray as an innovative approach to manage gastrointestinal bleeding are promising, further studies are needed to support and confirm its efficacy and safety. The aim of this study was to evaluate the technical feasibility, clinical efficacy, and safety of hemostatic powder spray (Hemospray, Cook Medical, Winston-Salem, North Carolina, USA) as a new method for managing gastrointestinal bleeding. In this review article, we performed an extensive literature search summarizing case reports and case series of Hemospray for the management of gastrointestinal bleeding. Indications, features, technique, deployment, success rate, complications, and limitations are discussed. The combined technical and clinical success rate of Hemospray was 88.5% (207/234) among the human subjects and 81.8% (9/11) among the porcine models studied. Rebleeding occurred within 72 hours post-treatment in 38 patients (38/234; 16.2%) and in three porcine models (3/11; 27.3%). No procedure-related adverse events were associated with the use of Hemospray. Hemospray appears to be a safe and effective approach in the management of gastrointestinal bleeding.

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Section: Resultsmentioning

confidence: 99%

Section: Adverse Events and Limitationsmentioning

confidence: 99%

Hemostatic powder spray: a new method for managing gastrointestinal bleeding

Changela

Papafragkakis

Ofori

et al. 2015

Therap Adv Gastroenterol

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“…Elastic band ligation, for example, traditionally used for variceal bleeding, has been recently proposed for the treatment of several non-variceal causes of UGIB, including gastric and duodenal ulcer bleeding, with a reported success rate of 96.5% (44). Similarly, and although comparative studies with conventional hemostatic clips are still lacking, an increasing number of studies have been reporting the successful use of OTSC in the control of ulcer bleeding, including ulcers of difficult access such as posterior duodenal bulb wall or cases refractory to other hemostatic strategies (45)(46)(47).…”

Section: Gastroduodenal Ulcer Bleedingmentioning

confidence: 99%

New insights on an old medical emergency: non-portal hypertension related upper gastrointestinal bleeding

Cúrdia-Gonçalves¹,

Rosa²,

Cotter³

2016

Rev Esp Enferm Dig

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Upper gastrointestinal bleeding (UGIB) is a potentially life-threatening condition and the most common medical emergency managed by gastroenterologists. Despite being one of the most antique medical problems, recent studies have been slowly changing the management of these patients, which should nowadays include not only initial resuscitation, but also risk stratification, pre-endoscopic therapy, endoscopy treatment, and post-procedure care. The aim of this paper is to review the extended approach to the patient with non-portal hypertension related UGIB.

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“…No entanto, em uma segunda endoscopia em 72 horas ( second look), nenhum dos participantes demonstrou sangramento ativo. 29 …”

Section: Métodos Mecânicosunclassified

Modalidades De Terapia Endoscópica Frente À Hemorragia Digestiva Alta Não-Varicosa

Sakuragi¹,

Bergamasco²,

Merlini³

2015

Bjim

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RESUMOA hemorragia digestiva alta não-varicosa ainda é uma frequente emergência médica, em especial nos pacientes com doença ulcerosa péptica. Estima-se uma incidência de até 99 casos por ano em 100.000 habitantes. Os locais de sangramento compreendem o esôfago, o estômago e o duodeno -porção acima do ligamento de Treitz. Embora a maioria dos episódios cesse espontaneamente, uma parcela expressiva de pacientes necessita de intervenção endoscópica. O presente estudo objetiva revisar as modalidades de terapia disponíveis por meio de endoscopia digestiva alta: injetáveis, termocoagulação, mecânicas, e mais recentemente, o hemospray; e dessa forma, avaliar a eficácia em termos de hemostasia, bem como as taxas de ressangramento e complicações. PALAVRAS-CHAVE: hemorragia digestiva alta não-varicosa; endoscopia digestiva alta; hemostase endoscópica. ABSTRACTThe nonvariceal upper gastrointestinal bleeding remains a common medical emergency, especially in patients with peptic ulcers. There is estimated an incidence of up 99 cases per year in 100.000 inhabitants. The sites of bleeding include the esophagus, stomach and duodenum -the portion above the ligament of Treitz. Although most episodes cease spontaneously, a significant proportion requires endoscopic intervention. This study aims to review the available modalities of endoscopic therapies: injection, thermocoagulation, mechanical, and more recently, hemospray; and thus, evaluate the effectiveness in terms os hemostasis, as well as the rates of rebleeding and complications.

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Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding

Abstract: These pilot results indicate that Hemospray is safe in humans. Hemospray was effective in achieving acute hemostasis in active peptic ulcer bleeding.

Cited by 228 publications

References 3 publications

Hemostatic powder spray: a new method for managing gastrointestinal bleeding

Hemostatic powder spray: a new method for managing gastrointestinal bleeding

New insights on an old medical emergency: non-portal hypertension related upper gastrointestinal bleeding

Modalidades De Terapia Endoscópica Frente À Hemorragia Digestiva Alta Não-Varicosa

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