Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence

Westman, Marit; Lupinek, Christian; Bousquet, Jean; Andersson, Niklas; Pahr, Sandra; Baar, Alexandra; Bergström, Anna; Holmström, Mats; Stjärne, Pär; Carlsen, Karin C. Lødrup; Carlsen, K. Lodrup; Antó, Josep M.; Valenta, Rudolf; Hage, Marianne van; Wickman, Magnus

doi:10.1016/j.jaci.2014.10.042

Cited by 126 publications

(165 citation statements)

References 34 publications

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“…An increased occurrence of allergic rhinitis with elevated Bet v 1-specific IgE levels or higher numbers of PR-10 molecule recognition proteins has been found in a pediatric population [29], and a strict relationship has been detected between the occurrence of OAS and higher Bet v 1 IgE levels [30,31]. Accordingly, we found higher Aln g 1, Bet v 1, Cor a 1.0101, Cor a 1.0401, Mal d 1, and Pru p 1 IgE levels in patients affected by OAS when compared with PR-10-reactive individuals without food allergy, as also suggested by previous observations with an extract-based diagnostic approach [32,33], thus demonstrating that a broader range of PR-10 detection can be useful to unveil more aggressive clinical profiles.…”

Section: Discussionmentioning

confidence: 99%

Molecular Recognition Profiles and Clinical Patterns of PR-10 Sensitization in a Birch-Free Mediterranean Area

Scala

Abeni

Cecchi³

et al. 2017

Int Arch Allergy Immunol

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Background: The order Fagales represents an important cause of tree-pollen allergy in northern countries. We investigated the IgE recognition profiles, mutual relationships, and association with clinical symptoms of a panel of allergens belonging to the PR-10 family, the main proteins responsible for Fagales allergy (Act d 8, Aln g 1, Api g 1, Ara h 8, Bet v 1, Cor a 1.0101, Cor a 1.0401, Gly m 4, Mal d 1, and Pru p 1). Methods: A total of 526 PR-10-reactive subjects living in central and southern Italy were studied by ImmunoCAP-ISAC-112 microarray analysis. Results: Overall, Bet v 1 reactivity was the most commonly (74%) observed among PR-10 proteins, but Cor a 1.0101 was the most prevalent in participants aged <6 years, and between 15 and 65 years. Overall, 26% of the PR-10-reactive persons were Bet v 1 negative, whilst 93.6% of the PR-10 polyreactive individuals were Bet v 1 positive. Among the 10 PR-10s evaluated, 100 combinations were recorded. The strongest association was observed between molecules with the highest sequence identities (Bet v 1 and Cor a 1.0101, Cor a 1.0401 or Aln g 1; Mal d 1 and Pru p 1). Bet v 1-, Cor a 1.0101-, and Aln g 1-specific IgE recognition was associated with respiratory symptoms, whilst Ara h 8, Cor a 1.0401, Gly m 4, Mal d 1, and Pru p 1 were selectively linked to an oral allergic syndrome. Conclusions: Testing IgE reactivity to a panel of PR-10s in a birch-free area discloses peculiar relationships between clinical phenotypes and sensitization profiles, allowing the identification of novel cluster patterns.

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Section: Discussionmentioning

confidence: 99%

Molecular Recognition Profiles and Clinical Patterns of PR-10 Sensitization in a Birch-Free Mediterranean Area

Scala

Abeni

Cecchi³

et al. 2017

Int Arch Allergy Immunol

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“…Two EU-funded projects are currently ongoing: U-BIOPRED (IMI) in severe asthma (57) and MeDALL (FP7) in allergy (58,59). MeDALL has already made critical observations concerning IgE biomarkers for the diagnosis and prognosis of allergic diseases (2,60). It is hoped that these projects will help identify biomarkers to enhance personalized medicine (61,62) and to improve patient stratification and clinical trials.…”

Section: Biomarkers In Respiratory Allergic Diseasesmentioning

confidence: 99%

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Bousquet

Schünemann

Fonseca

et al. 2015

Allergy

174

172

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“…32 BAMSE (Barn Allergi Miljö Stockholm Epidemiologi Projektet) 33 y Me-DALL (Mechanisms of the Development of Allergy;) 34 identificaron un fenotipo de alergia raro pero grave: fenotipo polisensibilizado-multimórbido, confirmado en cohortes de niños y adultos. 35,36,37,38 Estas investigaciones confirman que los sujetos polisensibilizados y multimórbidos tienen una frecuencia muy alta de síntomas alérgicos, síntomas persistentes a lo largo del tiempo, síntomas más graves de asma o rinitis y niveles más altos de IgE total y específica.…”

Section: Estratificación De Pacientes Con Alergia O Asma Graveunclassified

Resumen ejecutivo de ARIA 2016: vías integradas de atención para la medicina predictiva a lo largo del ciclo de vida en Argentina

Ivancevich

Neffen²,

Zernotti

et al. 2017

RAM

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The ARIA initiative was started during a World Health Organization workshop in 1999. The initial goals were to propose a new classification for allergic rhinitis, to promote the concept of multimorbidity in asthma and rhinitis and to develop guidelines with stakeholders for world-wide use. ARIA is now focused on the implementation of emerging technologies for individualized and predictive medicine. MASK: MACVIA-Aria Sentinel Network uses mobile technology to develop care pathways that enable management by a multidisciplinary group or by patients themselves. An App for iOS and Android uses a visual analogue scale to assess symptom control and work productivity, as well as a clinical decision support system; it is associated with an interoperable tablet for health professionals. The escalation strategy uses recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of ARIA's new approach is to provide an active and healthy life to people affected by rhinitis, regardless of age, gender or socioeconomic status, in order to reduce social and health inequalities caused by the disease.

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Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence

Abstract: ARbp at age 16 years can be predicted by analysis of IgE reactivity to PR-10 proteins in early childhood.

Cited by 126 publications

References 34 publications

Molecular Recognition Profiles and Clinical Patterns of PR-10 Sensitization in a Birch-Free Mediterranean Area

Molecular Recognition Profiles and Clinical Patterns of PR-10 Sensitization in a Birch-Free Mediterranean Area

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Resumen ejecutivo de ARIA 2016: vías integradas de atención para la medicina predictiva a lo largo del ciclo de vida en Argentina

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