Early childhood adversity and late-life depressive symptoms: unpacking mediation and interaction by adult socioeconomic status

Yazawa, Aki; Shiba, Koichiro; Inoue, Yosuke; Okuzono, Sakurako S.; Inoue, Kosuke; Kondo, Naoki; Kondo, Katsunori; Kawachi, Ichiro

doi:10.1007/s00127-022-02241-x

Cited by 21 publications

(14 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A longitudinal study has indicated that the association of physical abuse with glucose metabolism may be largely explained by adulthood obesity while the association of less severe adversities (e.g., emotional neglect) was mostly explained by childhood socioeconomic factors [47]. Moreover, given the relatively small mediation proportion in our study, other mediators of biological and psychological mechanisms including adult socioeconomic status [48], attachment and mood symptoms [49] may exist. Thus, comprehensively understanding the character of diverse childhood adversities and the underlying mechanism of how they affect late-life health is necessary, and then we could tailor the programs targeting childhood adversity.…”

Section: Discussionmentioning

confidence: 81%

Association of childhood adversity with frailty and the mediating role of unhealthy lifestyle: Findings from the UK biobank

Yang¹,

Cao²,

Yu³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Childhood adversity and lifestyle have been associated with frailty in later life, but not much is known about factors that may explain these associations. An unhealthy lifestyle may play an important role in the pathway from childhood adversity to frailty. Therefore, this study aims to investigate the association of childhood adversity with frailty, and the mediating role of unhealthy lifestyle in the association. Methods: This lifespan analysis included 152914 adults aged 40-69 years old from the UK Biobank. We measured childhood adversity with five items: physical neglect, emotional neglect, sexual abuse, physical abuse, and emotional abuse through online mental health survey. Frailty was measured by the frailty index; an unhealthy lifestyle score (range: 0-5) was calculated based on unhealthy body mass index, smoking, drinking, physical inactivity, and unhealthy diet at the baseline survey. Multiple logistic regression and mediation analysis were performed. Results: A total of 10078 participants (6.6%) were defined as having frailty. Participants with any childhood adversity had higher odds of frailty. For example, in the fully adjusted model, with a one-point increase in cumulative score of childhood adversity, the odds of frailty increased by 41% (Odds Ratio: 1.41; 95% Confidence Interval: 1.39, 1.44). Unhealthy lifestyle partially mediated the associations of childhood adversity with frailty (mediation proportion: 4.4%-7.0%). The mediation proportions were largest for physical (8.2%) and sexual (8.1%) abuse. Conclusions: Among this large sample, childhood adversity was positively associated with frailty, and unhealthy lifestyle partially mediated the association. This newly identified pathway highlights the potential of lifestyle intervention strategies among those who experienced childhood adversity (in particular, physical and sexual abuse) to promote healthy aging.

show abstract

Section: Discussionmentioning

confidence: 81%

Association of childhood adversity with frailty and the mediating role of unhealthy lifestyle: Findings from the UK biobank

Yang¹,

Cao²,

Yu³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The effects of sense of acceptance, teachers, friends and classroom climate on mental health were investigated at one point in time, and a causal relationship was not noted. Socioeconomic status, academic achievement and personality are associated with the quality of parent–child relationships and mental health (Jardim et al, 2019; Yazawa et al, 2022). Therefore, these variables need to be controlled because they may be confounders associated with both independent and dependent variables.…”

Section: Discussionmentioning

confidence: 99%

Examining the moderating effects of school factors on sense of acceptance and mental health: A multilevel analysis

Yanagi

2023

Child Abuse Review

View full text Add to dashboard Cite

Children who feel unaccepted by their mothers tend to have poor mental health. Although school factors (social support from homeroom or from teachers and friends, as well as classroom satisfaction) can protect students, few studies have examined these factors at the classroom level. Understanding the relationships between sense of acceptance, school factors and mental health may help students. This study, conducted in Japan, examines how sense of acceptance at the student level and school factors at the student and classroom levels affect the mental health variables of depression, loneliness, subjective happiness and emotional wellbeing. In total, 1470 Japanese school students (8–15 years old) from 68 classes participated. Multilevel analysis was conducted at the student and classroom levels. At the classroom level, social support from friends was associated with lower depression and loneliness and higher emotional wellbeing (p < 0.01). A positive classroom climate moderated the relationships of sense of acceptance with depression, loneliness, subjective happiness and emotional wellbeing (p < 0.05). Social support from friends at the classroom level and positive classroom climate at the student level serve as protective factors for students who feel unaccepted by their mothers. More activities boosting classroom student interactions would benefit such students.

show abstract

“…In sensitivity analyses we excluded women with symptoms that could indicate preclinical or undiagnosed RA (i.e., moderate-to-severe joint pain without doctor diagnosed arthritis or missing data on arthritis: 5,343 noncases, 35 cases). We also ran models excluding women with depressive symptoms (8,859 noncases, 44 cases), which may be a cause or effect of chronic inflammation, autoimmunity, and response to pain, and may also result from earlier life events and past trauma (38)(39)(40)(41).…”

Section: Stress and Covariatesmentioning

confidence: 99%

Life Events, Caregiving, and Risk of Autoimmune Rheumatic Diseases in the Women's Health Initiative Observational Study

Parks

Pettinger

Roos

et al. 2023

Arthritis Care & Research

View full text Add to dashboard Cite

ObjectiveGrowing evidence suggests psychosocial stressors may increase risk of developing autoimmune disease. We examined stressful life events and caregiving in relation to incident rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in the Women's Health Initiative Observational Study cohort.MethodsThe sample of postmenopausal women included 211 incident RA or SLE cases reported within 3 years after enrollment, confirmed by use of disease‐modifying antirheumatic drugs (i.e., probable RA/SLE), and 76,648 noncases. Baseline questionnaires asked about life events in the past year, caregiving, and social support. We used Cox regression models to calculate hazard ratios (HR) and 95% confidence intervals (95% CIs), adjusting for age, race/ethnicity, occupational class, education, pack‐years of smoking and BMI.ResultsIncident RA/SLE was associated with reporting 3 or more life events (e.g., age‐adjusted HR 1.70 [95% CI 1.14, 2.53]; P for trend = 0.0026). Elevated HRs were noted for physical (HR 2.48 [95% CI 1.02, 6.04]) and verbal (HR 1.34 [0.89, 2.02]) abuse (P for trend = 0.0614), 2 or more interpersonal events (HR 1.23 [95% CI 0.87, 1.73]; P for trend = 0.2403), financial stress (HR 1.22 [95% CI 0.90, 1.64]), and caregiving 3 or more days per week (HR 1.25 [95% CI 0.87, 1.81]; P for trend = 0.2571). Results were similar, excluding women with baseline symptoms of depression or moderate‐to‐severe joint pain in the absence of diagnosed arthritis.ConclusionOur findings support the idea that diverse stressors may increase risk of developing probable RA or SLE in postmenopausal women, supporting the need for further studies in autoimmune rheumatic diseases, including childhood adverse events, life event trajectories, and modifying psychosocial and socioeconomic factors.

show abstract

Early childhood adversity and late-life depressive symptoms: unpacking mediation and interaction by adult socioeconomic status

Cited by 21 publications

References 52 publications

Association of childhood adversity with frailty and the mediating role of unhealthy lifestyle: Findings from the UK biobank

Association of childhood adversity with frailty and the mediating role of unhealthy lifestyle: Findings from the UK biobank

Examining the moderating effects of school factors on sense of acceptance and mental health: A multilevel analysis

Life Events, Caregiving, and Risk of Autoimmune Rheumatic Diseases in the Women's Health Initiative Observational Study

Contact Info

Product

Resources

About