Early changes of immunoreactivity to orexin in hypothalamus and to RFamide peptides in brainstem during the development of hypertension

Yilmaz, Ajda; Kalsbeek, Andries; Buijs, Ruud M.

doi:10.1016/j.neulet.2021.136144

Cited by 2 publications

(1 citation statement)

References 72 publications

(59 reference statements)

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“…When injected into the caudal ventrolateral medulla, PrRP increased the mean arterial pressure, heart rate, and renal sympathetic nerve activity [325]. Furthermore, PrRP cells in the NTS showed reduced PrRP immunoreactivity before and during the development of hypertension in spontaneously hypertensive rats [326], which may have been a sign of a prolonged release.…”

Section: Prrpmentioning

confidence: 97%

Brain RFamide Neuropeptides in Stress-Related Psychopathologies

Kovács,

Szabó,

László

et al. 2024

Cells

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The RFamide peptide family is a group of proteins that share a common C-terminal arginine–phenylalanine–amide motif. To date, the family comprises five groups in mammals: neuropeptide FF, LPXRFamides/RFamide-related peptides, prolactin releasing peptide, QRFP, and kisspeptins. Different RFamide peptides have their own cognate receptors and are produced by different cell populations, although they all can also bind to neuropeptide FF receptors with different affinities. RFamide peptides function in the brain as neuropeptides regulating key aspects of homeostasis such as energy balance, reproduction, and cardiovascular function. Furthermore, they are involved in the organization of the stress response including modulation of pain. Considering the interaction between stress and various parameters of homeostasis, the role of RFamide peptides may be critical in the development of stress-related neuropathologies. This review will therefore focus on the role of RFamide peptides as possible key hubs in stress and stress-related psychopathologies. The neurotransmitter coexpression profile of RFamide-producing cells is also discussed, highlighting its potential functional significance. The development of novel pharmaceutical agents for the treatment of stress-related disorders is an ongoing need. Thus, the importance of RFamide research is underlined by the emergence of peptidergic and G-protein coupled receptor-based therapeutic targets in the pharmaceutical industry.

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Section: Prrpmentioning

confidence: 97%

Brain RFamide Neuropeptides in Stress-Related Psychopathologies

Kovács,

Szabó,

László

et al. 2024

Cells

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Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure

Lee,

Amatya,

Villar

et al. 2024

Sci Rep

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The kidney and brain play critical roles in the regulation of blood pressure. Neuropeptide FF (NPFF), originally isolated from the bovine brain, has been suggested to contribute to the pathogenesis of hypertension. However, the roles of NPFF and its receptors, NPFF-R1 and NPFF-R2, in the regulation of blood pressure, via the kidney, are not known. In this study, we found that the transcripts and proteins of NPFF and its receptors, NPFF-R1 and NPFF-R2, were expressed in mouse and human renal proximal tubules (RPTs). In mouse RPT cells (RPTCs), NPFF, but not RF-amide-related peptide-2 (RFRP-2), decreased the forskolin-stimulated cAMP production in a concentration- and time-dependent manner. Furthermore, dopamine D1-like receptors colocalized and co-immunoprecipitated with NPFF-R1 and NPFF-R2 in human RPTCs. The increase in cAMP production in human RPTCs caused by fenoldopam, a D1-like receptor agonist, was attenuated by NPFF, indicating an antagonistic interaction between NPFF and D1-like receptors. The renal subcapsular infusion of NPFF in C57BL/6 mice decreased renal sodium excretion and increased blood pressure. The NPFF-mediated increase in blood pressure was prevented by RF-9, an antagonist of NPFF receptors. Taken together, our findings suggest that autocrine NPFF and its receptors in the kidney regulate blood pressure, but the mechanisms remain to be determined.

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Early changes of immunoreactivity to orexin in hypothalamus and to RFamide peptides in brainstem during the development of hypertension

Cited by 2 publications

References 72 publications

Brain RFamide Neuropeptides in Stress-Related Psychopathologies

Brain RFamide Neuropeptides in Stress-Related Psychopathologies

Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure

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