Early changes induced by environmental stresses in insulin sensitivity-related genes

Sato, Masao; Ishibashi, Satoshi; Higashimoto, Minoru; Kadota, Yoshito; Kawakami, Toru; Suzuki, Shinya

doi:10.1016/j.ejphar.2011.07.034

Cited by 8 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, whether the decrease in IS is diet-related or part of the genetic programming of calves (transition from preruminant to ruminant) is not clear and needs to be investigated. Another factor that can modulate IS is environmental stress (Sato et al, 2011). Hugi et al (1997) measured the urinary excretion of noradrenaline and dopamine in veal calves and found a significant 3.…”

Section: Development Of Ismentioning

confidence: 99%

Lactose in milk replacer can partly be replaced by glucose, fructose, or glycerol without affecting insulin sensitivity in veal calves

Pantophlet

Gilbert

Borne

et al. 2016

Journal of Dairy Science

View full text Add to dashboard Cite

Calf milk replacer (MR) contains 40 to 50% lactose. Lactose strongly fluctuates in price and alternatives are desired. Also, problems with glucose homeostasis and insulin sensitivity (i.e., high incidence of hyperglycemia and hyperinsulinemia) have been described for heavy veal calves (body weight >100 kg). Replacement of lactose by other dietary substrates can be economically attractive, and may also positively (or negatively) affect the risk of developing problems with glucose metabolism. An experiment was designed to study the effects of replacing one third of the dietary lactose by glucose, fructose, or glycerol on glucose homeostasis and insulin sensitivity in veal calves. Forty male Holstein-Friesian (body weight = 114 ± 2.4 kg; age = 97 ± 1.4 d) calves were fed an MR containing 462 g of lactose/kg (CON), or an MR in which 150 g of lactose/kg of MR was replaced by glucose (GLU), fructose (FRU), or glycerol (GLY). During the first 10 d of the trial, all calves received CON. The CON group remained on this diet and the other groups received their experimental diets for a period of 8 wk. Measurements were conducted during the first (baseline) and last week of the trial. A frequently sampled intravenous glucose tolerance test was performed to assess insulin sensitivity and 24 h of urine was collected to measure glucose excretion. During the last week of the trial, a bolus of 1.5 g of [U-13 C] substrates was added to their respective meals and plasma glucose, insulin, and 13 C-glucose responses were measured. Insulin sensitivity was low at the start of the trial and remained low [1.2 ± 0.1 and 1.0 ± 0.1 (mU/L) −1 × min −1 ], and no treatment effect was noted. Glucose excretion was low at the start of the trial (3.4 ± 1.0 g/d), but increased in CON and GLU calves (26.9 ± 3.9 and 43.0 ± 10.6 g/d) but not in FRU and GLY calves. Postprandial glucose was higher in GLU, lower in FRU, and similar in GLY compared with CON calves. Postprandial insulin was lower in FRU and GLY and similar in GLU compared with CON calves. Postprandial 13 C-glucose increased substantially in FRU and GLY calves, indicating that calves are able to partially convert these substrates to glucose. We concluded that replacing one third of lactose in MR by glucose, fructose, or glycerol in MR differentially influences postprandial glucose homeostasis but does not affect insulin sensitivity in veal calves.

show abstract

Section: Development Of Ismentioning

confidence: 99%

Lactose in milk replacer can partly be replaced by glucose, fructose, or glycerol without affecting insulin sensitivity in veal calves

Pantophlet

Gilbert

Borne

et al. 2016

Journal of Dairy Science

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies indicate that stress is associated with increased risk of dementia and AD (Wilson et al, 2006). Repeated exposure of rats to mild stressors resulted in enhanced expression of adiponectin mRNA, suggesting that adipose tissue is sensitive to environmental stress (Sato et al, 2011). However, the effect of stress on the expression of adiponectin receptors has not yet been published in a scientific paper.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin Receptors Are Less Sensitive to Stress in a Transgenic Mouse Model of Alzheimer's Disease

et al. 2017

View full text Add to dashboard Cite

Background: Adiponectin and leptin are implicated in the initiation and pathomechanism of Alzheimer's disease (AD). The serum concentrations of these adipokines has been extensively studied in AD, however little is known about their receptors in this disease.Objective: We developed a novel approach to examine whether the receptors of adiponectin (AdipoR1 and -R2) and/or leptin (LepR) can contribute to AD pathomechanism. To achieve this, we investigated the effect of both genetic and environmental factors associated with AD on the expression of these receptors.Method: We used C57BL/6J (WT) and APP(swe)/Presen(e9d)1 (AD) mice. Both strains were exposed to restraint stress (RS) daily for 6h over different time periods. Then, we measured the mRNA expression of AdipoR1, AdipoR2 and LepR and the level of AdipoR1 and AdipoR2 proteins in the hippocampal and prefrontal cortical areas of each mouse.Results: We detected brain region specific transcriptomic changes of adiponectin receptors induced by APP and PS1 transgenes. Both acute and chronic RS caused significant elevations in AdipoR1 mRNA expression in the hippocampus of WT mice. In the prefrontal cortex, the mRNA expression of AdipoR1 followed a biphasic course. In AD mice, RS did not promote any changes in the expression of AdipoR1 mRNA and AdipoR1 protein levels. AdipoR2 mRNA in AD animals, however, showed a significant increase in the prefrontal cortex during RS. Regarding AdipoR1 and AdipoR2 mRNA and protein expression, relevant changes could be measured during stress exposure in both brain areas. Furthermore, stress exposed groups exhibited little change in LepR mRNA expression.Conclusion: Our findings indicate that carrying the transgenes associated with AD induces modification in the expression of both adiponectin receptors. In the case of a normal genetic background, these receptors also appear to be sensitive to environmental factors, while in a genetically determined AD model less response to stress stimuli could be observed. The results suggest that modification of adipokine receptors could also be considered in the therapeutic approach to AD.

show abstract

“…Attaching a clamp to the tail of rats is mildly stressful (Gibb et al, 2008; Kirby et al, 1997) and repeated exposures to the test (e.g. daily for 10 days) do not induce chronic stress responses (Sato et al, 2011). Physiological and behavioral responses to the test are highly stable over time.…”

Section: Introductionmentioning

confidence: 99%

The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats

et al. 2013

View full text Add to dashboard Cite

Rationale Coping styles are fundamental characteristics of behavior that affect susceptibility to, and resilience during, mental and physical illness. Shifts from passive to active coping are considered therapeutic goals in many stress-related disorders, but the neural control of coping is poorly understood. Based on earlier findings we hypothesized that coping styles are influenced by endocannabinoids. Objectives Here we tested whether FAAH inhibition by URB597 affects behaviors aimed at controlling a critical situation and the degree to which environmental stimuli influence behavior i.e. we studied the impact of URB597 on the two main attributes of coping styles. Methods Rats were tested in the tail-pinch test of coping and in the elevated plus-maze test that was performed under highly divergent conditions. Results Under the effects of URB597, rats focused their behavior more on the discomfort-inducing clamp in the tail pinch test, i.e. they coped with the challenge more actively. In the elevated plus-maze, URB597-treated rats demonstrated an autonomous behavioral control by reducing both "wariness" induced by aversive conditions and "carelessness" resulting from favorable conditions. Conclusions URB597 treatment induced behavioral changes indicative of a shift towards active coping with challenges. This behavioral change appears compatible with the previously suggested role of endocannabinoids in emotional homeostasis. Albeit further studies are required to characterize the role of endocannabinoids in coping, these findings suggest that the enhancement of endocannabinoid signaling may become a therapeutic option in emotional disorders characterized by passive coping (e.g. anxiety and depression) and in physical diseases where active coping is therapeutically desirable.

show abstract

Early changes induced by environmental stresses in insulin sensitivity-related genes

Cited by 8 publications

References 28 publications

Lactose in milk replacer can partly be replaced by glucose, fructose, or glycerol without affecting insulin sensitivity in veal calves

Lactose in milk replacer can partly be replaced by glucose, fructose, or glycerol without affecting insulin sensitivity in veal calves

Adiponectin Receptors Are Less Sensitive to Stress in a Transgenic Mouse Model of Alzheimer's Disease

The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats

Contact Info

Product

Resources

About