2019
DOI: 10.1002/jor.24563
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Early changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening

Abstract: Biomarkers are of interest to identify patients at risk for peri‐implant osteolysis and aseptic loosening. We used a rat model of particle‐induced peri‐implant osteolysis to investigate if early changes in biomarkers were associated with subsequent implant fixation strength. Implants were placed in rat femora, which were then challenged with intra‐articular knee injections of either clean polyethylene, lipopolysaccharide‐doped polyethylene, or cobalt‐chromium alloy particles, with particle‐free vehicle serving… Show more

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Cited by 2 publications
(11 citation statements)
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“…Specifically, in this experiment peri‐implant bone volume (BV/TV) varied among the experimental groups (1‐way ANOVA: P = .001) with significant decreases in both the CoCr (Bonferroni: P < .001) and LPS‐PE (Bonferroni: P < .001) groups compared to naïve rats 57 . CoCr (Bonferroni: P < .001) and LPS‐PE‐treated (Bonferroni: P = .001) rats also had significantly lower BV/TV than rats treated with clean‐PE 57 . The loss of peri‐implant BV/TV was accompanied by depressed implant fixation strength, a preclinical surrogate of implant loosening (1‐way ANOVA: P = .002), with decreased fixation strength with CoCr treatment compared to vehicle‐treated (Bonferroni: P = .007) and clean PE group (Bonferroni: P = .002) with a trend in the same direction compared to the LPS‐PE group (Bonferroni: P = .051).…”
Section: Resultsmentioning
confidence: 75%
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“…Specifically, in this experiment peri‐implant bone volume (BV/TV) varied among the experimental groups (1‐way ANOVA: P = .001) with significant decreases in both the CoCr (Bonferroni: P < .001) and LPS‐PE (Bonferroni: P < .001) groups compared to naïve rats 57 . CoCr (Bonferroni: P < .001) and LPS‐PE‐treated (Bonferroni: P = .001) rats also had significantly lower BV/TV than rats treated with clean‐PE 57 . The loss of peri‐implant BV/TV was accompanied by depressed implant fixation strength, a preclinical surrogate of implant loosening (1‐way ANOVA: P = .002), with decreased fixation strength with CoCr treatment compared to vehicle‐treated (Bonferroni: P = .007) and clean PE group (Bonferroni: P = .002) with a trend in the same direction compared to the LPS‐PE group (Bonferroni: P = .051).…”
Section: Resultsmentioning
confidence: 75%
“…Specifically, in this experiment peri-implant bone volume (BV/TV) varied among the experimental groups (1-way ANOVA: P = .001) with significant decreases in both the CoCr (Bonferroni: P < .001) and LPS-PE (Bonferroni: P < .001) groups compared to naïve rats. 57 CoCr (Bonferroni: P < .001) and LPS-PE-treated (Bonferroni: P = .001) rats also had significantly lower BV/TV than rats treated with clean-PE. 57 The loss of F I G U R E 3 Mason's Trichrome Staining of Knee Joints.…”
Section: When Particle Challenge Caused Depressed Implant Fixationmentioning
confidence: 91%
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