Early cerebellar hemispherectomy in the rat. Effects on the maturation of two hindlimb muscles and on lumbar motoneurones

Gramsbergen, Albert; Ijkema‐Paassen, Jos

doi:10.1016/0166-4328(93)90024-k

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…Although it is conceivable that the reduced fiber number after neonatal sciatic nerve crush could reflect a failure of new fiber generation, there is no evidence of any such increase in fiber number in either EDL (20) or SOL (20, 53) after 5 days of age. In fact, the loss of muscle fibers in transiently denervated EDL (and also TA) is paralleled by the loss of a significant proportion of motor neurons normally innervating these muscles.…”

Section: Discussionmentioning

confidence: 99%

Neurotrophic factors enhance the survival of muscle fibers in EDL, but not SOL, after neonatal nerve injury

Mousavi

Miranda²,

Parry

2002

American Journal of Physiology-Cell Physiology

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Neonatal sciatic nerve crush results in a sustained reduction of the mass of both extensor digitorum longus (EDL) and soleus (SOL) muscles in the rat. Type IIB fibers are selectively lost from EDL. We have investigated the effects of ciliary neurotrophic factor (CNTF) combined with neurotrophin (NT)-3 or NT-4 on muscle mass, as well as the number, cross-sectional area, and distribution of muscle fiber types and the number of motor neurons innervating EDL and SOL 3 mo after transient axotomy 5 days after birth. Both NT treatments prevented the axotomy-induced loss of muscle mass in both EDL and SOL and of total number of muscle fibers in EDL but not in SOL. Although IIB fiber loss was not prevented, both NT treatments resulted in altered fiber type distribution. Both NT combinations also reduced the loss of EDL motor neurons. These data suggest that a differential distribution of NT receptors on either motor neurons or muscle fibers may lead to different levels of susceptibility to neonatal axotomy.

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Section: Discussionmentioning

confidence: 99%

Neurotrophic factors enhance the survival of muscle fibers in EDL, but not SOL, after neonatal nerve injury

Mousavi

Miranda²,

Parry

2002

American Journal of Physiology-Cell Physiology

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“…63,82 As seen in both animal and human studies, brain plasticity allows the reorganization of certain motor and sensory functions in the healthy hemisphere. [85][86][87][88] Cerebral reorganization and early improvement in motor function are better seen after early surgical intervention (during the first year of life). [89][90][91][92] In one study using transcranial magnetic stimulation (TMS), the degree of motor cortex reorganization did not correlate with the degree of motor dysfunction.…”

Section: Outcome and Predictorsmentioning

confidence: 99%

Hemispherotomy for Epilepsy: The Procedure Evolution and Outcome

Alotaibi

Albaradie

Almubarak

et al. 2020

Can. J. Neurol. Sci.

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Hemispherectomy is a unique epilepsy surgery procedure that has undergone significant modification and evolution since Dandy’s early description. This procedure is mainly indicated to treat early childhood and infancy medically intractable epilepsy. Various epileptic syndromes have been treated with this procedure, including hemimegalencephaly (HME), Rasmussen’s encephalitis, Sturge–Weber syndrome (SWS), perinatal stroke, and hemispheric cortical dysplasia. In terms of seizure reduction, hemispherectomy remains one of the most successful epilepsy surgery procedures. The modification of this procedure over many years has resulted in lower mortality and morbidity rates. HME might increase morbidity and lower the success rate. Future studies should identify the predictors of outcomes based on the pathology and the type of hemispherectomy. Here, based on a literature review, we discuss the evolution of hemispherectomy techniques and their outcomes and complications.

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Early ontogeny of locomotor behaviour: a comparison between altricial and precocial animals

Muir

2000

Brain Research Bulletin

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Early cerebellar hemispherectomy in the rat. Effects on the maturation of two hindlimb muscles and on lumbar motoneurones

Cited by 4 publications

References 36 publications

Neurotrophic factors enhance the survival of muscle fibers in EDL, but not SOL, after neonatal nerve injury

Neurotrophic factors enhance the survival of muscle fibers in EDL, but not SOL, after neonatal nerve injury

Hemispherotomy for Epilepsy: The Procedure Evolution and Outcome

Early ontogeny of locomotor behaviour: a comparison between altricial and precocial animals

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