Early cardiac rehabilitation for acute decompensated heart failure safely improves physical function (PEARL study): a randomized controlled trial

Nakaya, Yuta; Akamatsu, Masanori; Ogimoto, Akiyoshi; Kitaoka, Hiroaki

doi:10.23736/s1973-9087.21.06727-7

Cited by 9 publications

(3 citation statements)

References 33 publications

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“…Improved SPPB score was related to better prognosis in patients with HF ( 26 ). The PEARL study and the REHAB-HF trial showed CR could improve the SPPB score among elderly patients with ADHF ( 14 , 27 ). However, re-hospitalization rate was not included as a study endpoint in PEARL study.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of Phase I Cardiac Rehabilitation in Patients Hospitalized in Cardiac Intensive Care Unit With Acute Decompensated Heart Failure: A Study Protocol for a Randomized, Controlled, Clinical Trial

Chen

Xue

et al. 2022

Front. Cardiovasc. Med.

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BackgroundCardiac rehabilitation (CR) improves outcomes in patients with heart failure. However, data on CR efficacy in patients with acute decompensated heart failure is limited. This study is designed to assess the efficacy and safety of CR in patients hospitalized in cardiac intensive care unit (CICU) with acute decompensated heart failure (ADHF).MethodsThis is a single-center, randomized controlled, single-blind clinical trial. A total of 120 participants hospitalized in CICU with ADHF will be randomly allocated in the ratio of 1:1 to two groups: CR group and control group. Participants will receive tailored and progressive CR intervention or attention control. The CR intervention include personalized breathing training, small muscle group resistance training, and aerobic endurance training based on the physical fitness assessment results. The subjects will receive the CR training for 5 days and will be followed up for 6 months. The primary endpoints are the score of the short physical performance battery (SPPB) and 6-month all-cause rehospitalization. The secondary endpoints include cardio-pulmonary function, activities of daily living (ADL), in-hospital mortality rate and 6-month all-cause mortality rate.DiscussionThis randomized, controlled, clinical trial will assess whether CR improves physical function and reduces rehospitalization in patients hospitalized in CICU with ADHF. The results will provide further research-based evidence for the clinical application of CR in patients with ADHF.Trial RegistrationChinese Clinical Trial Registry ChiCTR2100050151. Registered on 19 August 2021.

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Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of Phase I Cardiac Rehabilitation in Patients Hospitalized in Cardiac Intensive Care Unit With Acute Decompensated Heart Failure: A Study Protocol for a Randomized, Controlled, Clinical Trial

Chen

Xue

et al. 2022

Front. Cardiovasc. Med.

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“…The PEARL study demonstrated improvements in a physical performance battery after cardiac rehab; despite reporting no adverse outcomes, improvement in death and hospitalization was not measured. 109 Other trials have demonstrated a reversal of some frailty in heart failure patients, 110,111 which may translate into reducing poor outcomes indirectly. Others have shown improvement in mental health after these programs.…”

Section: Preoperative Anemiamentioning

confidence: 99%

Prehabilitation of Cardiac Surgical Patients, Part 1: Anemia, Diabetes Mellitus, Obesity, Sleep Apnea, and Cardiac Rehabilitation

Knight

Subramanian

Sultan

et al. 2022

Semin Cardiothorac Vasc Anesth

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The concept of “prehabilitation” consists of screening for and identification of pre-existing disorders followed by medical optimization. This is performed for many types of surgery, but may have profound impacts on outcomes particularly in cardiac surgery given the multiple comorbidities typically carried by these patients. Components of prehabilitation include direct medical intervention by preoperative specialists as well as significant care coordination and shared decision making. In this two-part review, the authors describe existing evidence to support the optimization of various preoperative problems and present a few institutional protocols utilized by our center for cardiac presurgical care. This first installment will focus on the management of anemia, obesity, sleep apnea, diabetes, and cardiac rehabilitation prior to surgery. The second will focus on frailty, malnutrition, respiratory disease, alcohol and smoking cessation, and depression.

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“…Trachsel et al(Trachsel et al, 2019). en su investigación bajo el mismo método también registró mejoras significativas de la frecuencia cardiaca dando como resultado un valor de p= 0.79, lo que permite deducir que ambos métodos resultaron efectivos.En la valoración de la capacidad cardio pulmonar medida por la prueba de caminata de 6 minutos, posterior a la aplicación del ejercicio aeróbico, según Zebin et al(Wen & Zhang, 2022), se consiguió mejorar la distancia recorrida de 165.5 ±67.1 a 324.5 ±70.8 m, parecido a lo expresado por Nacaya et al(Nakaya et al, 2021), que logró excelentes resultados en el grupo de intervención comparado con el grupo control reportando un progreso de 176.3-300 m vs 135-318 m, de igual manera Lautaris et…”

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Efectividad de los métodos aeróbico continuo e interválico de alta intensidad en adultos con insuficiencia cardiaca. Revisión sistemática

De la Torre,

Grijalva,

Paredes

2024

LATAM

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La insuficiencia cardíaca es una enfermedad cardiovascular que dificulta bombear sangre oxigenada de manera eficiente al resto del cuerpo. La rehabilitación cardiaca es un programa que incluye ejercicios, modificaciones de factores de riesgo cardiovascular y mejora de la calidad de vida. Los métodos aeróbico continuo e interválico de alta intensidad son ejercicios indicados en esta patología. El objetivo es determinar la efectividad del ejercicio aeróbico continuo e interválico de alta intensidad en pacientes adultos con insuficiencia cardiaca. Método: Se empleó las directrices de la declaración PRISMA, a partir de la búsqueda de los términos DECS MeSH “medical subject headings” en la National Center for Biotechnology Informartion (NCBI) y en el portal de Descriptores en Ciencias de la Salud (DeCs). Las bases de datos consultadas fueron: PubMed, Science Direct, Scielo en idiomas inglés y español; se combinaron los términos MeSH y DeCS con los operadores boleanos AND y OR. La población correspondió a las edades de 60 a ≥80, el resultado en la prueba de esfuerzo fue p<0.044 (velocidad), p<0.001 (inclinación), p=0.009 (tiempo) después del ejercicio aeróbico continuo y un valor de p=0.025 (velocidad), p=0.005 (inclinación), p=0.002 (tiempo) posterior al HIIT. En cuanto a la FEVI con los ejercicios aeróbicos los resultados variaron de 43.5±5.3 a 79±1.2, y con el HIIT mejoraron del 17.4% a 31.1%. El resultado de la función ventricular izquierda con el ejercicio aeróbico fue p<0.01 y con HIIT p=0.041. Ambos métodos consiguieron mejoras estadísticamente significativas en la función cardiopulmonar.

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Early cardiac rehabilitation for acute decompensated heart failure safely improves physical function (PEARL study): a randomized controlled trial

Cited by 9 publications

References 33 publications

The Efficacy and Safety of Phase I Cardiac Rehabilitation in Patients Hospitalized in Cardiac Intensive Care Unit With Acute Decompensated Heart Failure: A Study Protocol for a Randomized, Controlled, Clinical Trial

The Efficacy and Safety of Phase I Cardiac Rehabilitation in Patients Hospitalized in Cardiac Intensive Care Unit With Acute Decompensated Heart Failure: A Study Protocol for a Randomized, Controlled, Clinical Trial

Prehabilitation of Cardiac Surgical Patients, Part 1: Anemia, Diabetes Mellitus, Obesity, Sleep Apnea, and Cardiac Rehabilitation

Efectividad de los métodos aeróbico continuo e interválico de alta intensidad en adultos con insuficiencia cardiaca. Revisión sistemática

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