"Early" breast cancer detection using techniques other than mammography

Kopans, D. B.

doi:10.2214/ajr.143.3.465

Cited by 46 publications

(18 citation statements)

References 16 publications

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“…Nonmammographic breast-imaging techniques other than ultrasound and MRI have been studied, and several reviews of such alternative technologies are available [5]- [7]. Although extensively studied, passive microwave radiometry (thermography) [8] was not considered promising in two of these reviews [5], [6].…”

Section: Background Literaturementioning

confidence: 99%

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Two-dimensional FDTD analysis of a pulsed microwave confocal system for breast cancer detection: fixed-focus and antenna-array sensors

Hagness

Taflove²,

Bridges

1998

IEEE Trans. Biomed. Eng.

490

312

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Abstract-A novel focused active microwave system is investigated for detecting tumors in the breast. In contrast to X-ray and ultrasound modalities, the method reviewed here exploits the breast-tissue physical properties unique to the microwave spectrum, namely, the translucent nature of normal breast tissues and the high dielectric contrast between malignant tumors and surrounding lesion-free normal breast tissues. The system uses a pulsed confocal technique and time-gating to enhance the detection of tumors while suppressing the effects of tissue heterogeneity and absorption. Using published data for the dielectric properties of normal breast tissues and malignant tumors, we have conducted a two-dimensional (2-D) finite-difference timedomain (FDTD) computational electromagnetics analysis of the system. The FDTD simulations showed that tumors as small as 2 mm in diameter could be robustly detected in the presence of the background clutter generated by the heterogeneity of the surrounding normal tissue. Lateral spatial resolution of the tumor location was found to be about 0.5 cm.

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Section: Background Literaturementioning

confidence: 99%

“…Although extensively studied, passive microwave radiometry (thermography) [8] was not considered promising in two of these reviews [5], [6].…”

Section: Background Literaturementioning

confidence: 99%

Two-dimensional FDTD analysis of a pulsed microwave confocal system for breast cancer detection: fixed-focus and antenna-array sensors

Hagness

Taflove²,

Bridges

1998

IEEE Trans. Biomed. Eng.

490

312

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“…l9 We believe, along with other authors, that low values of sensitivity in thermography render this technique unsuitable for the diagnosis and treatment of routine breast lesions. 15,[18][19][20]28,29 On the basis of these findings, we suggest that clinical examination, mammography, and fine-needle aspiration are, when combined, the best diagnostic methods for a correct preoperative assessment of mammary lesions. Each technique detects cases that others do not, because each technique has different limitations.…”

Section: I2-l4mentioning

confidence: 99%

Preoperative diagnostic accuracy of fine‐needle aspiration in the management of breast lesions: Comparison of specificity and sensitivity with clinical examination, mammography, echography, and thermography in 249 patients

Negri

Bonetti

Capitanio

et al. 1994

Diagnostic Cytopathology

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Two hundred and forty-nine women suffering from breast problems underwent a complete series of tests including clinical examination, mammography, echography, thermography, and fine-needle aspiration (FNA). Ninety-four of these patients were shown to be positive or to have suspected malignancy. Accordingly, they underwent surgical excision followed by histologic examination, while the remaining patients were re-examined after 12 to 18 mo in order to exclude false negatives. The analysis of specificity and sensitivity of every single procedure showed that FNA describes the best degree of sensitivity and specificity but no procedure allows, by itself, the detection of all carcinomas. When considered in combination, clinical examination, mammography, and fine-needle aspiration have a sensitivity of 100% and a specificity of 49%, and are the best diagnostic tests for a correct assessment of mammary lesions. Thermography and echography showed a low degree of sensitivity and should not be included in the routine diagnostic procedure of breast lesions.

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“…Chang ve ekibi intravenöz iyotlu kontrast ajan verilerek meme kanserinin saptanabileceğini ileri sürmüşlerdir (28). Ancak çok çekim gerektirmesi ve dolayısıyla tüm toraks dahil hastanın yüksek doz radyasyona maruz kalması bir sorundur (29). Ayrıca, son çalışmalarda ameliyat öncesi lezyon işaretlemede "MR kılavuzluğunda" meme BT kullanımı gün-demdedir (30,31).…”

Section: Bilgisayarlı Tomografi (Bt)unclassified

Occult Breast Cancer

Kebudi¹

2013

J Breasth Health

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Breast carcinoma is the most common malignancy in women after skin cancer and, after lung cancer, the most frequent cause of cancer death in females. With advances in screening over the past 25 years, fewer than 10% of patients will present with metastatic breast carcinoma at the time of diagnosis. Occult breast carcinoma presenting axillary metastases is uncommon and accounts for less than 1% of newly diagnosed breast carcinoma. However, it continues to be a challenging diagnostic and therapeutic problem. In this review, the current approach to diagnosis and treatment of occult breast cancer is discussed. Okult primer meme kanserleri (OMK), T0N1 (evre II) olarak sınıf-landırılmaktadır. Aksiller metastazı olan OMK insidansı düşük-tür. Mamografi öncesi döneme ait üç geniş seride, bu oran tüm meme kanserleri içinde %0,30-1 (2-4) iken, mamografi dönemin-de dört geniş seride bu oran %0,34-0,88 olarak bulunmuştur (5-8) (Tablo 1).Mamografi, ultrasonografi (US) ve Manyetik Rezonanstaki (MR) gelişmelerle birlikte aksiller metastazlı OMK tanısında azalma söz konusudur. Curie Enstitüsü'nde 1960-1997 yılları arasında 59 hasta tedavi edilmiştir (9). Hastalarda medyan yaş 57 (36-79) idi. Otuz beş hasta (%58) postmenopozal dönemde ve iki hasta hormon replasman tedavisi görmekteydi. On beş hastada (%25) meme kanseri aile öyküsü saptandı. Ayrıca diğer çalışmalarda da, bu hasta grubunda ailesel meme kanseri öyküsü yüksek oranda bulunmuştur (6-8). Yirmi sekiz hastada (%47,5) sol aksiller nodlar ve 31 hastada da (%52,5) sağ aksiller nodlar ön plandaydı. TanıKlinik Muayene: OMK tanılı kadınların yaş ortalaması 45-55 arasıdır (10). Lenf nodlarının ortalama çapını Haagensen ve ekibi (11) ile Andrade ve ekibi (12) 4,7 cm, Curie Enstitüsü ise 3 cm olarak vermiştir (13). Nadiren, karşı memede kanser hikayesi olan hastalarda aksiller metastaz görülebilir (14,15). Bu durumda aksilladaki tutulumun nedeninin karşı taraftaki meme kanserinden mi, yoksa aynı taraftaki memedeki yeni, okult bir kanserden mi olduğunu söylemek zordur.Büyümüş aksiller lenf nodları genellikle selimdir, %70 oranında nonspesifik inflamatuvar veya hiperplastik değişikliklere bağlı, %7 oranında da granülomlara bağlı olarak gelişmektedir (16,17). Geriye kalan olgularda malign bir neden vardır. Kadınlarda en sık primer kanser, memenin adenokarsinomudur. Lenfoma ve metastatik kanserler de diğer sebeplerdir. Cilt melanomu, tiroid, akciğer, over, gastrointestinal ve böbrek hücreli kanserler, prostat kanseri meme bölgesine metastaz yapan kanserler olarak sayılabilir (18)(19)(20).Aksiller adenopatisi olan bir kadında tanı amacıyla yapılacak ilk iş, dikkatli bir anamnez alma ve iyi bir fizik muayenedir. Örneğin diğer lenf nodu bulunan bölgelerde yaygın lenfadenopati viral etyoloji

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"Early" breast cancer detection using techniques other than mammography

Cited by 46 publications

References 16 publications

Two-dimensional FDTD analysis of a pulsed microwave confocal system for breast cancer detection: fixed-focus and antenna-array sensors

Two-dimensional FDTD analysis of a pulsed microwave confocal system for breast cancer detection: fixed-focus and antenna-array sensors

Preoperative diagnostic accuracy of fine‐needle aspiration in the management of breast lesions: Comparison of specificity and sensitivity with clinical examination, mammography, echography, and thermography in 249 patients

Occult Breast Cancer

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