Early Biomarkers in Neonatal Necrotizing Enterocolitis: A Pilot Study

Elfarargy, Mohamed Shawky; Farargy, Mohamed S El; Atef, Marwa Mohamed; El-Deeb, Omnia Safwat; Elsharaby, Radwa Mahmoud; Elhady, Hany Abd Elfattah

doi:10.15586/jptcp.v26i3.602

Cited by 6 publications

(2 citation statements)

References 33 publications

(31 reference statements)

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“…Unfortunately, there are few studies on the relationship between PCT and NEC. Only a few studies have revealed that PCT can be used for the diagnosis of NEC, 39 , 40 but no research has focused on the use of PCT for the early prediction of the severity and prognosis of NEC in preterm infants. Our study found that in the early onset of NEC, PCT in the severe group was significantly higher than that in the mild-moderate group, suggesting that elevated PCT might be a risk factor for stage III NEC in preterm infants.…”

Section: Discussionmentioning

confidence: 99%

The Mean Platelet Volume Combined with Procalcitonin as an Early Accessible Marker Helps to Predict the Severity of Necrotizing Enterocolitis in Preterm Infants

Cai¹,

Liao²,

Chen³

et al. 2022

IJGM

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Purpose This study aims to evaluate the value of the mean platelet volume (MPV) combined with procalcitonin (PCT) in predicting the severity of necrotizing enterocolitis (NEC) in preterm infants. Methods This was a retrospective cohort study conducted in a neonatal intensive care unit from January 2014 to July 2020. Premature neonates with NEC were enrolled. In this study, mild-moderate NEC was defined as Bell’s stage I and II, and severe NEC was defined as Bell’s stage III. The demographic data, blood cell count analysis, C-reactive protein and PCT were compared between the severe and mild-moderate groups. Results A total of 18 premature infants with NEC in the severe group and 57 infants in the mild-moderate group were enrolled. The MPV and PCT were all significantly higher in the severe group than in the mild-moderate group (P < 0.01), and white blood cells were lower in the severe group (P < 0.05). The results of logistic regression suggested that the MPV (OR = 6.194, P = 0.000) and PCT (OR = 1.093, P = 0.006) were independent predictive factors for the severity of NEC. A receiver operating characteristic analysis showed that the areas under the curve (AUCs) were 0.829 for MPV alone, 0.706 for PCT alone, and 0.895 for MPV combined with PCT. Conclusion The combination of MPV with PCT had the highest overall AUC of the investigated parameters, and their combination can be considered an early marker for predicting the severity of NEC in preterm infants.

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Section: Discussionmentioning

confidence: 99%

The Mean Platelet Volume Combined with Procalcitonin as an Early Accessible Marker Helps to Predict the Severity of Necrotizing Enterocolitis in Preterm Infants

Cai¹,

Liao²,

Chen³

et al. 2022

IJGM

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“…They demonstrated that PCT had the highest specificity (98%) and PPV (97%), but lowest sensitivity (92%) and NPV (94%) of the 3 markers. Elfarargy et al ( 30 ) conducted a case control study of 20 healthy neonates and 20 with NEC and reported that there was an increase in faecal calprotectin and serum levels of CRP, PCT and epithelial neutrophil activating peptide-78 (ENA-78), in the NEC group in comparison to the control group. These studies add weight to the suggestion that we should be using a combination of multiple different biomarkers to help identify NEC earlier.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of gut injury in neonates – where are we in predicting necrotising enterocolitis?

et al. 2022

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Despite advances in neonatal care Necrotising Enterocolitis (NEC) continues to have a significant mortality and morbidity rate, and with increasing survival of those more immature infants the population at risk of NEC is increasing. Ischaemia, reperfusion, and inflammation underpin diseases affecting intestinal blood flow causing gut injury including Necrotising Enterocolitis. There is increasing interest in tissue biomarkers of gut injury in neonates, particularly those representing changes in intestinal wall barrier and permeability, to determine whether these could be useful biomarkers of gut injury. This article reviews current and newly proposed markers of gut injury, the available literature evidence, recent advances and considers how effective they are in clinical practice. We discuss each biomarker in terms of its effectiveness in predicting NEC onset and diagnosis or predicting NEC severity and then those that will aid in surveillance and identifying those infants are greatest risk of developing NEC.

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Diagnostic value of fecal calprotectin in necrotizing enterocolitis: A meta-analysis

Han

et al. 2020

Early Human Development

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Early Biomarkers in Neonatal Necrotizing Enterocolitis: A Pilot Study

Cited by 6 publications

References 33 publications

The Mean Platelet Volume Combined with Procalcitonin as an Early Accessible Marker Helps to Predict the Severity of Necrotizing Enterocolitis in Preterm Infants

The Mean Platelet Volume Combined with Procalcitonin as an Early Accessible Marker Helps to Predict the Severity of Necrotizing Enterocolitis in Preterm Infants

Biomarkers of gut injury in neonates – where are we in predicting necrotising enterocolitis?

Diagnostic value of fecal calprotectin in necrotizing enterocolitis: A meta-analysis

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