Early benefit of preserved cognitive function is not sustained at one-year after cardiac surgery: a longitudinal follow-up of the randomized controlled trial

Djaiani, George; Katznelson, Rita; Fedorko, Ludwik; Rao, Vivek; Green, Robin; Carroll, Jo

doi:10.1007/s12630-012-9675-y

Cited by 20 publications

(17 citation statements)

References 27 publications

(35 reference statements)

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“…A total of 155 (69%) of the original sample of 226 patients also consented for the current study and hence were tested for genotype. Postoperative cognitive dysfunction one year after surgery was present in 31 (20%) patients . There were no differences with respect to baseline characteristics, pre‐operative variables and surgical data between patients with and without POCD (Table ).…”

Section: Resultsmentioning

confidence: 94%

“…Patients were also asked separately to consent to testing of blood samples for genotyping purposes, and these samples were stored for later testing. Patient exclusion criteria, peri‐operative management strategies, and neuropsychological testing were previously described . The current study consisted of the subset of patients who consented for genotyping, and was carried out after the conclusion of the original study, with separate funding.…”

Section: Methodsmentioning

confidence: 99%

“…Postoperative cognitive dysfunction (POCD) occurs in 10–17% of patients one year after cardiac and non‐cardiac surgery . The rate of late cognitive decline is similar in surgical patients and age‐adjusted non‐surgical controls .…”

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confidence: 99%

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Genetic variation and cognitive dysfunction one year after cardiac surgery

et al. 2013

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SummaryVarious studies have implicated a potential association between candidate gene polymorphisms and postoperative cognitive dysfunction, yet corroborative studies are lacking. We investigated the variants in genes encoding platelet glycoprotein-IIIa and apolipoprotein-E and their relationship with postoperative cognitive dysfunction one year after cardiac surgery. A total of 155 patients were studied; neuropsychological testing demonstrated cognitive dysfunction in 31 (20%) patients at one-year follow-up. No differences were detected with respect to baseline characteristics, preoperative variables and surgical data between the patients with and without cognitive dysfunction. The Pl A2 -allele of the platelet glycoprotein-IIIa gene was present in 13 (42%) and 25 (20%) patients with and without cognitive dysfunction, respectively, p = 0.012. The apolipoprotein E-e4 allele was present in 9 (29%) and 24 (19%) patients with and without cognitive dysfunction, respectively, p = 0.24. Both the Pl A2 and apolipoprotein-e4 alleles were present together in 6 (19%) and 5 (4%) patients with and without cognitive dysfunction, respectively, p = 0.003. Validation of these findings is required in age-adjusted non-surgical controls.

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Section: Resultsmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

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Genetic variation and cognitive dysfunction one year after cardiac surgery

et al. 2013

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“…However, in 42% of patients cognitive impairment persists beyond 5 years after CABG. The aim of the research was to investigate incidence of cognitive impairment after CABG under the circumstances of artificial circulation in the early postoperative period (Evered, Silbert, Scott, Maruff, & Ames, 2016;Hogan, Shipolini, Brown, Hurley, & Cormack, 2013;Djaiani, Katznelson, Fedorko, Rao, Green, Carroll, & Karski, 2012).…”

Section: State Of the Problemmentioning

confidence: 99%

Proceedings of the Iii International Scientific and Practical Conference “Psychological Health of the Person: Life Resource and Life Potential”

2017

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The Proceedings cover different aspects of mental health research concerned with human life resource and life potential, as well as applied aspects of health psychology.The editorial policy was based on the principles of selection and reviewing of all submitted manuscripts. At the first stage all the manuscripts underwent an initial review by the Editor-in-Chief and the Editorial Board before peer-review in order to assess whether their content complied with the Conference theme. The manuscripts which did not comply with the subject matter of the Conference have been rejected. At the second stage all the manuscripts underwent a double blind review process: each work was reviewed by two experts from the Board of Reviewers; reviewing procedure was anonymous both for the experts and authors.In case of positive review results provided by both experts the contributions were included in the Editor-in-Chief Portfolio. At the third stage manuscripts underwent scientific style as well as language literacy assessment and language editing. This work was carried out by the team of Language Editors. Based on the results of the three stages of reviewing the list of the manuscripts recommended for the publication in the Conference Proceedings has been defined.The problem of assessment, prophylaxis and preserving human psychological health is of utmost importance today. Its relevance is determined, first, by the fact that both a person and his / her development as a healthy and autonomous personality represent a subject of a psychological research. Second, recent global transformations impose special requirements to the person seeking for health preservation, self-development, and self-actualisation. Among these requirements there is readiness to act in new, unpredictable conditions, to make decisions in unstable situations and to bear responsibility for one's decisions. To meet these requirements, a person should be able to see opportunities for self-development and self-fulfillment in the surrounding world, finding new meanings of his / her life activity.Existence of life resource and life potential expands the scope of any person's activities, turning the person's significant life purposes into more achievable ones. Resources are known to subjectively increase the value of a person both in his / her self-perception and in the eyes of others, making the person stronger, more prominent and proactive.Among various human resources health is a fundamental one. At the same time, life potential is not a less important characteristic, since it ensures human capacity to create, develop and use life conditions, factors and circumstances which are beneficial for an organism.Considering human health through the prism of life potential, it is necessary that the value of health within culture of its formation should be the highest, being defined not so much by the need for self-preservation but for self-improvement.The presented Proceedings are the result of both scientific studies in Psychology and fruitful and prospective long-term inte...

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“…These include chronic progressive vascular disease and inflammatory brain damage, further complicating the use of coronary artery bypass graft surgery as an ischemic brain injury model for proof of concept studies. 66,70 The ischemic injury during carotid stenting and endarterectomy probably replicates laboratory stroke most consistently in that stroke is caused by abrupt vessel occlusion. However, it occurs in the background of chronically ischemic tissue, induced by high-grade carotid disease.…”

Section: Potential Pitfallsmentioning

confidence: 99%