Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping

Aguiar, Pedro Valente; Sousa, Osvaldo; Silva, R.; Vaz, Ruí; Linhares, Paulo

doi:10.1016/j.neucir.2020.09.003

Cited by 1 publication

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References 14 publications

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“…The treatment of LGG is a comprehensive treatment based on maximum surgical resection, but progression of deterioration is still inevitable, and patients often have adverse outcomes such as multicentre recurrence and meningeal dissemination 10‐12 . SUMOylation, as a covalent modification, occurs mainly in lysine residues 13 and plays an important role in maintaining protein stability and stress response 14 .…”

Section: Discussionmentioning

confidence: 99%

Construction of a SUMOylation regulator‐based prognostic model in low‐grade glioma

Meng

2021

J Cellular Molecular Medi

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Low‐grade glioma (LGG) is an intracranial malignant tumour that mainly originates from astrocytes and oligodendrocytes. SUMOylation is one of the post‐translational modifications but studies of SUMOylation in LGG is quite limited. Transcriptome data, single nucleotide variant (SNV) data and clinical data of LGG were derived from public databases. The differences between the expression of SUMOylation regulators in LGG and normal brain tissue were analysed. Cox regression was used to construct a prognostic model in the training cohort. Kaplan‐Meier survival curves and ROC curves were plotted in the training and the validation cohort to evaluate the effectiveness of the prognostic model. GO and KEGG analyses were applied to preliminarily analyse the biological functions. Compared with normal brain tissue, SENP1 and SENP7 were up‐regulated and SENP5 was down‐regulated in LGG. SUMOylation regulators may be involved in functions such as mRNA splicing, DNA replication, ATPase activity and spliceosome. One prognostic model was established based on the 4 SUMOylation regulator‐related signatures (RFWD3, MPHOSPH9, WRN and NUP155), which had a good predictive ability for overall survival. This study is expected to provide targets for the diagnosis and treatment of low‐grade glioma.

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Section: Discussionmentioning

confidence: 99%

Construction of a SUMOylation regulator‐based prognostic model in low‐grade glioma

Meng

2021

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping

Cited by 1 publication

References 14 publications

Construction of a SUMOylation regulator‐based prognostic model in low‐grade glioma

Construction of a SUMOylation regulator‐based prognostic model in low‐grade glioma

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