Early Atherosclerotic Changes in the Patients with Idiopathic Epilepsy: Egyptian Preliminary Study

Shaheen, Hala A.; Sayed, Sayed S; Daker, Lamiaa I.; Magdy, Mostafa M

doi:10.4172/2472-0895.1000112

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…5 It was found that cytochrome P450 enzyme induction might reduce the feedback inhibition of 3-hydroxy-3methylglutaryl coenzyme A synthesis, and subsequently resulted in increasing the level of cholesterol. 35 It was found that epileptic patients maintained on carbamazepine or valproate monotherapy-as in our studyhave increased cholesterol and TG concentrations. 36 The role of AEDs in the pathogenesis of atherosclerosis is not fully understood.…”

Section: Discussionsupporting

confidence: 67%

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The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs

Nasef,

Elmala,

Sayed Ahmed

et al. 2023

Global Pediatric Health

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Objectives. To evaluate carotid artery intima-media thickness (CIMT) and lipid profile in children with epilepsy on long-term antiepileptic drug (AED) monotherapy. Methods. We included 60 children with epilepsy receiving valproate, carbamazepine, or levetiracetam monotherapy and 60 controls. A high-resolution B-mode ultrasound was used to measure (CIMT). Measurement of serum lipids was done. Results. Patients on valproate (0.44 ± 0.03, P ≤ .001), carbamazepine (0.43 ± 0.03with P ≤ .001), and levetiracetam (0.44 ± 0.02 with P ≤ .001) monotherapy showed significantly higher CIMT compared to controls. CIMT was correlated with age ( P = .041, r = .112) AEDs{valproate ( P = .005, r = .731), carbamazepine ( P = .038, r = .365), and levetiracetam ( P = .036, r = .155)}, duration of treatment ( P = .001, r = .313), TC( P = .001, r = .192), TG ( P = .014, r = .018), and LDL ( P = .001, r = .219). HDL ( P = .003, r = −.126). Seizure severity and Apo A1 were insignificantly involved. Conclusion. Long-term monotherapy with valproate, carbamazepine, and levetiracetam in epileptic children was associated with significant abnormalities in CIMT.

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Section: Discussionsupporting

confidence: 67%

“…It was found that cytochrome P450 enzyme induction might reduce the feedback inhibition of 3-hydroxy-3- methylglutaryl coenzyme A synthesis, and subsequently resulted in increasing the level of cholesterol. 35 …”

Section: Discussionmentioning

confidence: 99%

The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs

Nasef,

Elmala,

Sayed Ahmed

et al. 2023

Global Pediatric Health

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NMR-based metabolomics in pediatric drug resistant epilepsy – preliminary results

Boguszewicz

Jamroz

Ciszek

et al. 2019

Sci Rep

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Epilepsy in children is the most frequent, heterogeneous and difficult to classify chronic neurologic condition with the etiology found in 35–40% of patients. Our aim is to detect the metabolic differences between the epileptic children and the children with no neurological abnormalities in order to define the metabolic background for therapy monitoring. The studied group included 28 epilepsy patients (median age 12 months) examined with a diagnostic protocol including EEG, videoEEG, 24-hour-EEG, tests for inborn errors of metabolism, chromosomal analysis and molecular study. The reference group consisted of 20 patients (median age 20 months) with no neurological symptoms, no development delay nor chronic diseases. 1H-NMR serum spectra were acquired on 400 MHz spectrometer and analyzed using multivariate and univariate approach with the application of correction for age variation. The epilepsy group was characterized by increased levels of serum N-acetyl-glycoproteins, lactate, creatine, glycine and lipids, whereas the levels of citrate were decreased as compared to the reference group. Choline, lactate, formate and dimethylsulfone were significantly correlated with age. NMR-based metabolomics could provide information on the dynamic metabolic processes in drug-resistant epilepsy yielding not only disease-specific biomarkers but also profound insights into the disease course, treatment effects or drug toxicity.

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Early Atherosclerotic Changes in the Patients with Idiopathic Epilepsy: Egyptian Preliminary Study

Abstract: Background: Patients with epilepsy are at higher risk for atherosclerosis which may be due to epilepsy or antiepileptic drugs. The frequency of atherosclerosis in patients with epilepsy was not previously studied in Egypt.

Cited by 2 publications

References 34 publications

The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs

The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs

NMR-based metabolomics in pediatric drug resistant epilepsy – preliminary results

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