Early assessment of visual function in full term newborns

Ricci, Daniela; Cesarini, Laura; Groppo, Michela; Carli, Agnese De; Gallini, Francesca; Serrao, Francesca; Fumagalli, Monica; Cowan, Frances; Ramenghi, Luca A.; Anker, S; Mercuri, Eugenio; Mosca, Fabio

doi:10.1016/j.earlhumdev.2007.03.010

Cited by 48 publications

(50 citation statements)

References 14 publications

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“…al., 2015, submitted). The major gain of the presented method lies in the possibility to assess more visual functions than is currently done in visual function assessments at a young age, and to assess them in a quantitative manner 26 . A limitation with respect to existing methods is that, without adaptations, it is not yet possible to thoroughly assess visual acuity or visual field with the present test battery 14 .…”

Section: Discussionmentioning

confidence: 99%

A Method to Quantify Visual Information Processing in Children Using Eye Tracking

Kooiker

Pel

Steen-Kant

et al. 2016

JoVE

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Visual problems that occur early in life can have major impact on a child's development. Without verbal communication and only based on observational methods, it is difficult to make a quantitative assessment of a child's visual problems. This limits accurate diagnostics in children under the age of 4 years and in children with intellectual disabilities. Here we describe a quantitative method that overcomes these problems. The method uses a remote eye tracker and a four choice preferential looking paradigm to measure eye movement responses to different visual stimuli. The child sits without head support in front of a monitor with integrated infrared cameras. In one of four monitor quadrants a visual stimulus is presented. Each stimulus has a specific visual modality with respect to the background, e.g., form, motion, contrast or color. From the reflexive eye movement responses to these specific visual modalities, output parameters such as reaction times, fixation accuracy and fixation duration are calculated to quantify a child's viewing behavior. With this approach, the quality of visual information processing can be assessed without the use of communication. By comparing results with reference values obtained in typically developing children from 0-12 years, the method provides a characterization of visual information processing in visually impaired children. The quantitative information provided by this method can be advantageous for the field of clinical visual assessment and rehabilitation in multiple ways. The parameter values provide a good basis to: (i) characterize early visual capacities and consequently to enable early interventions; (ii) compare risk groups and follow visual development over time; and (iii), construct an individual visual profile for each child.

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Section: Discussionmentioning

confidence: 99%

A Method to Quantify Visual Information Processing in Children Using Eye Tracking

Kooiker

Pel

Steen-Kant

et al. 2016

JoVE

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“…10 The final version of this assessment has been validated in a cohort of low-risk term-born infants as early as 48 hours from birth, providing normative data about the distribution of responses at this age. 11 The visual test battery was used recently in a study correlating the visual findings with probabilistic diffusion tractography of the optic radiations, suggesting that, in preterm infants at term-equivalent age, aspects of visual function are directly related to the maturation of white matter in the optic radiations.…”

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confidence: 99%

Visual Function at 35 and 40 Weeks' Postmenstrual Age in Low-Risk Preterm Infants

et al. 2008

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“…Bayley scales will be used to measure the major areas of development: cognitive, language, motor, social-emotional and adaptive functioning. Visual function will be assessed in the first ten days of life by means of a recently published battery of behavioural tests designed to assess various aspects of visual function [124,125], which includes items that assess ocular movements (spontaneous behaviour and in response to a target), the ability to fix and follow a black/white target (horizontally, vertically, and in an arc), the reaction to a colored target, the ability to discriminate between black and white stripes of increasing spatial frequency, and the ability to keep attention on a target that is moved slowly away from the infant. Visual function will be evaluated again at 4 ½, 6 and 12 months with particular regards to binocular visual acuity, measured by means of standardized instruments based on preferential force choice (Teller acuity cards), stereopsis and ocular motricity.…”

Section: Neurological Follow-upmentioning

confidence: 99%

Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI)

Filippi¹

2013

http://isrctn.org/>

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Background: Despite progresses in neonatal care, the mortality and the incidence of neuro-motor disability after perinatal asphyxia have failed to show substantial improvements. In countries with a high level of perinatal care, the incidence of asphyxia responsible for moderate or severe encephalopathy is still 2-3 per 1000 term newborns. Recent trials have demonstrated that moderate hypothermia, started within 6 hours after birth and protracted for 72 hours, can significantly improve survival and reduce neurologic impairment in neonates with hypoxic-ischemic encephalopathy. It is not currently known whether neuroprotective drugs can further improve the beneficial effects of hypothermia. Topiramate has been proven to reduce brain injury in animal models of neonatal hypoxic ischemic encephalopathy. However, the association of mild hypothermia and topiramate treatment has never been studied in human newborns. The objective of this research project is to evaluate, through a multicenter randomized controlled trial, whether the efficacy of moderate hypothermia can be increased by concomitant topiramate treatment. Methods/Design: Term newborns (gestational age ≥ 36 weeks and birth weight ≥ 1800 g) with precocious metabolic, clinical and electroencephalographic (EEG) signs of hypoxic-ischemic encephalopathy will be randomized, according to their EEG pattern, to receive topiramate added to standard treatment with moderate hypothermia or standard treatment alone. Topiramate will be administered at 10 mg/kg once a day for the first 3 days of life. Topiramate concentrations will be measured on serial dried blood spots. 64 participants will be recruited in the study. To evaluate the safety of topiramate administration, cardiac and respiratory parameters will be continuously monitored. Blood samplings will be performed to check renal, liver and metabolic balance. To evaluate the efficacy of topiramate, the neurologic outcome of enrolled newborns will be evaluated by serial neurologic and neuroradiologic examinations. Visual function will be evaluated by means of behavioural standardized tests.

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Early assessment of visual function in full term newborns

Cited by 48 publications

References 14 publications

A Method to Quantify Visual Information Processing in Children Using Eye Tracking

A Method to Quantify Visual Information Processing in Children Using Eye Tracking

Visual Function at 35 and 40 Weeks' Postmenstrual Age in Low-Risk Preterm Infants

Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI)

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