Early APV chronic blocked alters experience-dependent plasticity of auditory spatial representation in rat auditory cortical neurons

Cui, Yilei; Cai, Rui; Zhang, Ji Ping; Pan, Yanqun; Sun, Xinde

doi:10.1016/j.neulet.2010.05.001

Cited by 2 publications

(1 citation statement)

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“…NMDA receptors are critically involved in the generation of LTP or LTD in the neocortex and hippocampus (Malenka and Bear 2004;Morris 2013;Nabavi et al 2013). These receptors are also critical for experience-dependent plasticity in the barrel, visual, and auditory systems (Cui et al 2009(Cui et al , 2010Huang et al 2012). Our study showed for the first time that the form of plasticity caused by rhythmic vibrissal stimulation was also dependent on NMDA receptors like the electrically induced or experiencedependent plasticity in the hippocampus and neocortex.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Synaptic Plasticity in Rat Barrel Cortex

et al. 2014

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Rats generate sweeping whisker movements in order to explore their environments and identify objects. In somatosensory pathways, neuronal activity is modulated by the frequency of whisker vibration. However, the potential role of rhythmic neuronal activity in the cerebral processing of sensory signals and its mechanism remain unclear. Here, we showed that rhythmic vibrissal stimulation with short duration in anesthetized rats resulted in an increase or decrease in the amplitude of somatosensory-evoked potentials (SEPs) in the contralateral barrel cortex. The plastic change of the SEPs was frequency dependent and long lasting. The long-lasting enhancement of the vibrissa-to-cortex evoked response was side- but not barrel-specific. Local application of dl-2-amino-5-phosphonopentanoic acid into the barrel cortex revealed that this vibrissa-to-cortex long-term plasticity in adult rats was N-methyl-d-aspartate receptor-dependent. Most interestingly, whisker trimming through postnatal day (P)1-7 but not P29-35 impaired the long-term plasticity induced by 100 Hz vibrissal stimulation. The short period of rhythmic vibrissal stimulation did not induce long-lasting plasticity of field potentials in the thalamus. In conclusion, our results suggest that natural rhythmic whisker activity modifies sensory information processing in cerebral cortex, providing further insight into sensory perception.

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