Early antibiotic treatment (prophylaxis) of septic complications in severe acute necrotizing pancreatitis: a prospective, randomized, multicenter study comparing two regimens with imipenem-cilastatin

Abstract

Compared to a 14-day imipenem prophylaxis, a longer antibiotic administration in patients with ANP is not associated with a reduction in the incidence of septic complications of the disease. However, prolonged imipenem administration in patients with persisting systemic complications tends to reduce mortality in ANP compared to a 14-days regimen.

Antibiotic use in acute pancreatitis: An audit of current practice in a tertiary centre

“…Antibiotic prophylaxis to reduce infective complications in acute pancreatitis was evaluated in a series of randomized trials [4][5][6][7][8][9][10][11][12]. However meta-analyses of these trials do not support antibiotic prophylaxis in acute pancreatitis [13][14][15].…”

Pankreatitis akutua duen pazientearen artatzea

“… Paziente hauek ez dute inolako antibiotikorik behar, pankreako nekrosia infektatu ez dadin (23). Orain dela urte batzuk gomendatzen bazen ere, diseinu egokia zuten saiakuntza klinikoak garatzean erabileraren desegokitasuna frogatu zen, infekzioen eta hilkortasunaren tasa ez dutela hobetzen ikusi baitzen (24).  Sabelalde barruko presioaren neurketa.…”

Meta-analysis of prophylactic parenteral antibiotic use in acute necrotizing pancreatitis

“…However, the overall effect was presumably produced by parenteral administration of antibiotics, since recent metaanalysis defined protease inhibitors to have no effect on outcome in patients with severe acute pancreatitis (21). Based on our inclusion criteria and on the results of earlier publications, we have selected a total of 10 randomized or randomized controlled studies for the new meta-analysis (Table 1) (20,(22)(23)(24)(25)(26)(27)(28)(29)(30). There were 1279 patients included in the meta-analysis, of whom 641 received prophylactic antibiotics and 638 were allocated to control group.…”