Early and persistent increase in serum lipoprotein (a) concentrations in epileptic children treated with carbamazepine and sodium valproate monotherapy

Voudris, Konstantinos; Attilakos, Achilleas; Katsarou, Eustathia; Drakatos, Antonios; Dimou, Stamatia; Mastroyianni, Sotiria; Skardoutsou, Angeliki; Prassouli, Alexia; Garoufi, Anastasia

doi:10.1016/j.eplepsyres.2006.05.002

Cited by 38 publications

(28 citation statements)

References 23 publications

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“…Carbamazepine (CBZ) is a widely used antiepileptic drug [1,2]. The drug was originally evaluated for treating trigeminal neuralgia, but based on clinical experience it became the drug of choice for all partial and for tonic-clonic seizures [3].…”

Section: Introductionmentioning

confidence: 99%

Improved solubilization of carbamazepine and structural transitions in nonionic microemulsions upon aqueous phase dilution

Kogan

Aserin

Garti

2007

Journal of Colloid and Interface Science

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Section: Introductionmentioning

confidence: 99%

Improved solubilization of carbamazepine and structural transitions in nonionic microemulsions upon aqueous phase dilution

Kogan

Aserin

Garti

2007

Journal of Colloid and Interface Science

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“…Most of the patients with epilepsy require a long-term, and sometimes lifelong, therapy with antiepileptic drugs (AEDs) and, therefore, are exposed to the potential undesirable metabolic side effects of medical treatment [39][40][41]. These include alterations in the metabolism of homocysteine [5,37], lipoproteins [4,19,61,62,72] and vitamin D [7,16,18,46,50]. Given the fact that an adequate vitamin D status is of major importance for multiple health outcomes [9,26,70], the effects of AEDs on the vitamin D metabolism in children is of considerable interest.…”

mentioning

confidence: 99%

Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy

et al. 2008

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Reports of decreased serum 25-hydroxyvitamin D (25-OHD) and altered bone metabolism associated with antiepileptic drug (AED) treatment are inconsistent and predominantly restricted to adults. In this cross-sectional observational study, the aim was to evaluate the influence of AED treatment on vitamin D status and markers of bone turnover in children with epilepsy. In 38 children taking AEDs and 44 healthy control subjects, blood samples were collected to determine the levels of serum 25-OHD, intact parathyroid hormone (iPTH), calcium (Ca), phosphate (P), bone alkaline phosphatase (BAP), osteocalcin (OC) and C terminal telopeptide of type I collagen (ICTP). More than 75% of the patients were vitamin D deficient (serum 25-OHD<20 ng/mL) and 21% of the patients had an insufficient vitamin D status (serum 25-OHD=20-30 ng/mL). In the patients, the serum levels of OC (p = 0.002) and BAP (p < 0.001) were significantly increased, but ICTP (p = 0.002) concentrations were significantly decreased compared with the control group. When patients where divided into two groups according to their medication (mono- or polytherapy), significantly lower 25-OHD (p = 0.038) and ICTP (p = 0.005) levels and elevated BAP (p = 0.023) concentrations were found in patients under polytherapy. An association between 25-OHD and the measured bone markers could not be determined. Our results indicate that the prevalence of vitamin D deficiency in epilepsy patients under AED treatment is high, especially under polytherapy, and alteration markers of bone formation and resorption suggests an accelerated skeletal turnover. The routine monitoring of serum 25-OHD and vitamin D supplementation on an individual basis should be considered.

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“…Die Empfehlungen zur routinemäßi-gen Bestimmung der Lipidwerte [insbesondere Gesamtcholesterin, "high-density lipoprotein" (HDL), LDL, Triglyzeride, Lipoprotein (a)] reichen von "nicht erforderlich" [51] bis zur routinemäßigen Kontrolle der Lipide wegen der Korrelation von Lipidprofil und Arteriosklerose [54] bei Einnahme von Antiepileptika allgemein oder bei Einnahme bestimmter Antiepileptika wie der enzyminduzierenden Wirkstoffe, VPA und LEV [47,101]. …”

Section: Lipide Im Serumunclassified

Laboratory monitoring in the pharmacotherapy of epilepsy

Fröscher

Steinhoff

2011

Z. Epileptol.

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Early and persistent increase in serum lipoprotein (a) concentrations in epileptic children treated with carbamazepine and sodium valproate monotherapy

Cited by 38 publications

References 23 publications

Improved solubilization of carbamazepine and structural transitions in nonionic microemulsions upon aqueous phase dilution

Improved solubilization of carbamazepine and structural transitions in nonionic microemulsions upon aqueous phase dilution

Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy

Laboratory monitoring in the pharmacotherapy of epilepsy

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