Early and Late Therapy Response Assessment With [<sup>18</sup>F]Fluorodeoxyglucose Positron Emission Tomography in Pediatric Hodgkin's Lymphoma: Analysis of a Prospective Multicenter Trial

Furth, Christian; Steffen, Ingo G.; Amthauer, Holger; Ruf, Juri; Misch, Daniel; Schönberger, Stefan; Kobe, Carsten; Denecke, Timm; Stöver, B.; Hautzel, Hubertus; Henze, Günter; Hundsdoerfer, Patrick

doi:10.1200/jco.2008.19.7814

Cited by 140 publications

(107 citation statements)

References 36 publications

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“…The main advantage of PET in these settings is its ability to distinguish between viable tumor and fibrosis in residual masses. Conventional imaging methods such as CT and MR generally struggle in making this distinction (29)(30)(31). In children with Hodgkin lymphoma, data on early response assessment with 18 F-FDG PET have demonstrated a high negative predictive value, with an excellent prognosis for children showing a normalization of 18 F-FDG PET findings at an early time during chemotherapy (30,31).…”

Section: Lymphomamentioning

confidence: 99%

Potential Pediatric Applications of PET/MR

et al. 2014

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Medical imaging with multimodality and whole-body technologies has continuously improved in recent years. The advent of combined modalities such as PET/CT and PET/MR offers new tools with an exact fusion of molecular imaging and high-resolution anatomic imaging. For noninvasive pediatric diagnostics, molecular imaging and whole-body MR have become important, especially in pediatric oncology. Because it has a lower radiation exposure than PET/CT, combined PET/MR is expected to be of special use in pediatric diagnostics. This review focuses on possible pediatric applications of PET/MR hybrid imaging, particularly pediatric oncology and neurology but also the diagnosis of infectious or inflammatory diseases.

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Section: Lymphomamentioning

confidence: 99%

Potential Pediatric Applications of PET/MR

et al. 2014

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“…Semiquantitative and volumetric analyses of the primary tumors were performed using commercial software (Advantage Workstation version 4.4, GE Healthcare), which provides a convenient and automatic method to delineate the VOI of primary tumor using an isocontour threshold method based on SUV. In this study, mediastinal blood pool which was the reference organ for therapy response evaluation in lymphoma [17,18] activity was used as a threshold for determining tumor boundary. A VOI consisting of 5×5 voxels was drawn at the aortic arch on a transverse PET image.…”

Section: Image Analysismentioning

confidence: 99%

Prognostic Significance of Volume-based Metabolic Parameters by 18F-FDG PET/CT in Gallbladder Carcinoma

Yoo

Choi

Lee

et al. 2012

Nucl Med Mol Imaging

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Purpose We investigated the prognostic values of volumebased metabolic parameters by 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET)/computed tomography (CT) in gallbladder carcinoma patients and compared them with other prognostic parameters. Materials and Methods We enrolled 44 patients, who were initially diagnosed with gallbladder carcinoma and undergoing 18 F-FDG PET/CT. Various metabolic volume-based PET parameters of primary tumors, including maximum and average standardized uptake values (SUV max , SUV avg ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), were measured in gallbladder carcinoma patients using mediastinal blood pool activity as a threshold SUV for determining the tumor boundaries. Overall survival analysis was performed using the Kaplan-Meier method with PET parameters and other clinical variables. For determining independent prognostic factors, Cox proportional hazards regression analysis was performed. ResultsOf the 44 enrolled patients, cancer-or treatmentrelated death occurred in 30 (68.2 %). The mean clinical follow-up period was 22.2±10.4 m (range, 0.6-35.9 m). Univariate analysis demonstrated that clinical or pathologic TNM stage (P < 0.001), treatment modality (P <0.001), MTV (cutoff 0 135 cm 3 , P00.001), and TLG (cutoff 0 7,090, P<0.05) were significant prognostic factors. In multivariate analysis, both clinical or pathologic TNM stage [hazard ratio (HR)02.019 (I vs II), 21.287 (I vs III), and 24.354 (I vs IV); P00.001) and TLG (HR02.930; P<0.05) were independent prognostic factors for predicting overall survival. Conclusions In gallbladder cancer, TLG of the primary tumor, a volume-based metabolic parameter, is a significant independent prognostic factor for overall survival in conjunction with the clinical or pathological TNM stage.

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“…In Hodgkin lymphoma, accumulating evidence suggests that elimination of tumor metabolic activity, as determined by FDG-PET, may be the most important predictor of event-free and overall survival [15,[23][24][25][26]. The use of either CT or MRI in conjunction with these PET scans improves the specificity of a judiciously timed PET evaluation and provides essential anatomic correlation needed to guide subsequent treatment decisions, such as radiation treatment planning [15].…”

Section: Technical Considerationsmentioning

confidence: 99%

The ALARA concept in pediatric oncology

et al. 2009

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Early and Late Therapy Response Assessment With [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography in Pediatric Hodgkin's Lymphoma: Analysis of a Prospective Multicenter Trial

Abstract: Pediatric HL patients with a negative PET in response assessment have an excellent prognosis while PET-positive patients have an increased risk for relapse.

Cited by 140 publications

References 36 publications

Potential Pediatric Applications of PET/MR

Potential Pediatric Applications of PET/MR

Prognostic Significance of Volume-based Metabolic Parameters by 18F-FDG PET/CT in Gallbladder Carcinoma

The ALARA concept in pediatric oncology

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Early and Late Therapy Response Assessment With [18F]Fluorodeoxyglucose Positron Emission Tomography in Pediatric Hodgkin's Lymphoma: Analysis of a Prospective Multicenter Trial

Abstract: Pediatric HL patients with a negative PET in response assessment have an excellent prognosis while PET-positive patients have an increased risk for relapse.

Cited by 140 publications

References 36 publications

Potential Pediatric Applications of PET/MR

Potential Pediatric Applications of PET/MR

Prognostic Significance of Volume-based Metabolic Parameters by 18F-FDG PET/CT in Gallbladder Carcinoma

The ALARA concept in pediatric oncology

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Early and Late Therapy Response Assessment With [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography in Pediatric Hodgkin's Lymphoma: Analysis of a Prospective Multicenter Trial