Early and Late Presentations of Ethylene Glycol Poisoning

Ting, Stephen; Ching, Irene; Nair, Harikrishnan; Langman, Gerald; Suresh, V.; Temple, R. M.

doi:10.1053/j.ajkd.2008.12.019

Cited by 26 publications

(22 citation statements)

References 32 publications

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“…Although considered to be of low toxicity, if swallowed ethylene glycol (EG) can cause serious 15 , albeit rare 25,26 , acute poisoning that can occur accidentally at home to children 21 or through occupational exposure 1,27 and intentionally in suicide attempts 7,28,29 . In the rare 10,30 case of death reported, belonging to this last context, histopathological examination found intra-and extracellular microcalcifications in renal and cardiac tissues, characteristic findings described 29 as local or systemic calcium deposits in the acute harmful action induced by ethylene glycol 9,31 .…”

Section: Discussionmentioning

confidence: 99%

Histopathological findings of medico-legal significance in delayed death from ethylene glycol poisoning

Zoja¹,

Andreola²,

Gentile³

et al. 2013

Australian Journal of Forensic Sciences

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Section: Discussionmentioning

confidence: 99%

Histopathological findings of medico-legal significance in delayed death from ethylene glycol poisoning

Zoja¹,

Andreola²,

Gentile³

et al. 2013

Australian Journal of Forensic Sciences

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“…Our patient also displayed a neurological sequel which involved several cranial nerves similar to the case reports described. Ethylene glycol intoxication can also result in a neuropsychological sequelae [20]. Patients may have a decline in cognitive function that persists months after intoxication [20].…”

Section: Discussionmentioning

confidence: 99%

“…Ethylene glycol intoxication can also result in a neuropsychological sequelae [20]. Patients may have a decline in cognitive function that persists months after intoxication [20]. Patients may also have meningismus.…”

Section: Discussionmentioning

confidence: 99%

Severe Oxalosis With Systemic Manifestations

et al. 2012

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Ethylene glycol toxicity can have various clinical presentations with different organ system involvements. These presentations are independent of the level of toxicity. We describe a 31 years old male who presented with ethylene glycol toxicity manifesting as anuric renal failure who subsequently developed neurological sequela of its toxicity. Ethylene glycol is known to be metabolized to various metabolites and is ultimately converted to oxalate which results in crystal deposition the renal parenchyma causing renal failure. Oxalate deposition can occur in various organs including the nervous system as seen in our patient. The majority of patients do not recover from severe oxalosis despite the supportive care of hemodialysis in removing the parent compounds. Despite severe oxalosis, our patient was fortunate enough to be left with minimal neurological sequelae, and eventually was able to cease hemodialysis treatments.KeywordsEthylene glycol; Oxalate; Oxalosis; Glyoxylic acid

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“…Ethylene glycol is toxic, and its ingestion should be considered a medical emergency (28). Ethylene glycol may be swallowed accidentally, or it may be taken deliberately in a suicide attempt or as a substitute for drinking alcohol (ethanol) (16).…”

Section: Human Poisoning and Clinical Symptomsmentioning

confidence: 99%

Ethylene Glycol, Hazardous Substance in the Household

Patočka

Hon

2010

Acta Med. (Hradec Kralove, Czech Repub.)

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Ethylene glycol is a colorless, odorless, sweet-tasting but poisonous type of alcohol found in many household products. The major use of ethylene glycol is as an antifreeze in, for example, automobiles, in air conditioning systems, in de-icing fluid for windshields, and else. People sometimes drink ethylene glycol mistakenly or on purpose as a substitute for alcohol. Ethylene glycol is toxic, and its drinking should be considered a medical emergency. The major danger from ethylene glycol is following ingestion. Due to its sweet taste, peoples and occasionally animals will sometimes consume large quantities of it if given access to antifreeze. While ethylene glycol itself has a relatively low degree of toxicity, its metabolites are responsible for extensive cellular damage to various tissues, especially the kidneys. This injury is caused by the metabolites, glycolic and oxalic acid and their respective salts, through crystal formation and possibly other mechanisms. Toxic metabolites of ethylene glycol can damage the brain, liver, kidneys, and lungs. The poisoning causes disturbances in the metabolism pathways, including metabolic acidosis. The disturbances may be severe enough to cause profound shock, organ failure, and death. Ethylene glycol is a common poisoning requiring antidotal treatment.

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Early and Late Presentations of Ethylene Glycol Poisoning

Cited by 26 publications

References 32 publications

Histopathological findings of medico-legal significance in delayed death from ethylene glycol poisoning

Histopathological findings of medico-legal significance in delayed death from ethylene glycol poisoning

Severe Oxalosis With Systemic Manifestations

Ethylene Glycol, Hazardous Substance in the Household

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