Early and late onset depression in late life: a prospective study on clinical and structural brain characteristics and response to electroconvulsive therapy

Dols, Annemiek; Boeckaert, F.; Sienaert, Pascal; Rhebergen, Didi; Comijs, Hannie C.; Oudega, Mardien L.; Exel, Eric van; Vandenbulcke, Mathieu; Stek, Max L.

doi:10.1016/j.brs.2017.01.142

Cited by 10 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This leads to the hypothesis that WML may not be involved in the pathophysiology of severe LOD. Moreover, little differences were found between EOD and LOD in our cohort with severe LLD 20 indicating that age-at-onset may be an irrelevant specifier in severe depression.…”

Section: Discussionmentioning

confidence: 57%

“…These results are similar to our current findings and findings in our previous report, showing high ECT response rates in patients with severe LLD, high apathy scores, and WMH. 20…”

Section: Discussionmentioning

confidence: 99%

“…Patients were recruited for the Mood Disorders in Elderly treated with Electro-Convulsive Therapy (MODECT) study 20 from 2 tertiary psychiatric hospitals (GGZ inGeest, Amsterdam, the Netherlands and University Psychiatric Center, KU Leuven, Belgium) after being diagnosed with unipolar severe depression according to the DSM-IV-TR criteria. 21 The patients were aged 55 years or older.…”

Section: Methodsmentioning

confidence: 99%

“…18 However, electroconvulsive therapy (ECT) is equally effective in severely depressed patients with and without WMH. 19,20…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

Oudega

Siddiqui

Wattjes

et al. 2020

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

Objective: Apathy symptoms are defined as a lack of interest and motivation. Patients with late-life depression (LLD) also suffer from lack of interest and motivation and previous studies have linked apathy to vascular white matter hyperintensities (WMH) of the brain in depressed and nondepressed patients. The aim of this study was to investigate the relationship between apathy symptoms, depressive symptoms, and WMH in LLD. We hypothesize that late-onset depression (LOD; first episode of depression after 55 years of age) is associated with WMH and apathy symptoms. Methods: Apathy scores were collected for 87 inpatients diagnosed with LLD. Eighty patients underwent brain magnetic resonance imaging. Associations between depressive and apathy symptoms and WMH were analyzed using linear regression. Results: All 3 subdomains of the 10-item Montgomery–Åsberg Depression Rating Scale correlated significantly with the apathy scale score (all P < .05). In the total sample, apathy nor depressive symptoms were related to specific WMH. In LOD only, periventricular WMH were associated with depression severity (β = 5.21, P = .04), while WMH in the left infratentorial region were associated with apathy symptoms (β coefficient = 5.89, P = .03). Conclusion: Apathy and depressive symptoms are highly overlapping in the current cohort of older patients with severe LLD, leading to the hypothesis that apathy symptoms are part of depressive symptoms in the symptom profile of older patients with severe LLD. Neither apathy nor depressive symptoms were related to WMH, suggesting that radiological markers of cerebrovascular disease, such as WMH, may not be useful in predicting these symptoms in severe LLD.

show abstract

Section: Discussionmentioning

confidence: 57%

“…These results are similar to our current findings and findings in our previous report, showing high ECT response rates in patients with severe LLD, high apathy scores, and WMH. 20…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…18 However, electroconvulsive therapy (ECT) is equally effective in severely depressed patients with and without WMH. 19,20…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

Oudega

Siddiqui

Wattjes

et al. 2020

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

show abstract

“…5 Research investigating age of depression onset as a predictor of treatment response has also reported contradictory results. 12 For example, several studies have found that early onset depression is associated with poorer treatment response, 13 slower remission, 14 and higher rates of recurrence 15,16 compared to late-onset depression.…”

Section: Introductionmentioning

confidence: 99%

Resilience predicts remission in antidepressant treatment of geriatric depression

Laird¹,

Lavretsky²,

Cyr³

et al. 2018

Int J Geriat Psychiatry

View full text Add to dashboard Cite

show abstract

MMSE Changes During and After ECT in Late-Life Depression: A Prospective Study

Obbels

Vansteelandt

Verwijk

et al. 2019

The American Journal of Geriatric Psychiatry

View full text Add to dashboard Cite

There is ongoing concern about the impact of electroconvulsive therapy (ECT) on cognition in patients with late-life depression (LLD), especially in patients for whom pretreatment Mini-Mental State Exam (MMSE) scores are low. Our aim was to examine the evolution of cognitive effects of ECT, using the MMSE in a large group of patients with LLD. Methods: One hundred nine patients aged 55 years and older with unipolar depression, referred for ECT, were included in our study. The MMSE was assessed before, during, immediately after, and 6 months after ECT. Results: MMSE scores improved significantly during the course of ECT and remained stable during the 6-month period after ending ECT for the total group. In the group of patients with a low MMSE score (< 24) at baseline, the MMSE score improved significantly during ECT, whereas in the group of patients with a normal MMSE score (≥24) at baseline, the score did not change significantly during ECT. In both groups, MMSE scores still increased slightly after ECT was discontinued. Conclusion: ECT does not cause deleterious cognitive effects, as measured with the MMSE, during and for 6 months after the ECT course in patients with LLD. In the event of a baseline cognitive impairment, MMSE scores tend to improve significantly during and for 6 months after the ECT course. The presence of pretreatment cognitive impairment should not lead clinicians to withhold ECT in older patients with severe depression.

show abstract

Early and late onset depression in late life: a prospective study on clinical and structural brain characteristics and response to electroconvulsive therapy

Cited by 10 publications

References 0 publications

Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

Resilience predicts remission in antidepressant treatment of geriatric depression

MMSE Changes During and After ECT in Late-Life Depression: A Prospective Study

Contact Info

Product

Resources

About