Early and late neonatal septicaemia.

Placzek, Monica; Whitelaw, A

doi:10.1136/adc.58.9.728

Cited by 101 publications

(51 citation statements)

References 8 publications

(1 reference statement)

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“…Neonatal infection was diagnosed by clinical assessment, with or without positive cultures of blood, urine, gastric aspirate, or bronchial secretions. Only early infection (39). occumng within the first 48 h of delivery, was considered to have a potential influence on cytokine levels at birth.…”

Section: Cord Blood G a H Id Gm-csf Levels 165mentioning

confidence: 99%

Granulocyte and Granulocyte-Macrophage Colony-Stimulating Factors in Cord and Maternal Serum at Delivery

et al. 1994

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Section: Cord Blood G a H Id Gm-csf Levels 165mentioning

confidence: 99%

Granulocyte and Granulocyte-Macrophage Colony-Stimulating Factors in Cord and Maternal Serum at Delivery

et al. 1994

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“…4 However, in the developed countries, Gram positive organisms have been implicated as the most common causes. 5 The spectrum of organisms that causes neonatal sepsis changes over times and varies from region to region. This is due to the changing pattern of antibiotic use and changes in lifestyle.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of neonatal septicaemia in a tertiary care hospital in Mandya, Karnataka, India

Samaga

2016

Int J Res Med Sci

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Background: Neonatal sepsis is defined as a clinical syndrome in an infant 28 days of life or younger, manifested by systemic signs of infection and isolation of a bacterial pathogen from the bloodstream. Neonatal sepsis is caused by Gram-positive and Gram-negative bacteria and candida. Microbial invasion of the bloodstream can have serious consequences such as shock, multi-organ failure, disseminated intravascular coagulation (DIC) and death. This study was conducted to know the prevalence of neonatal septicaemia. Methods: This retrospective observational study was conducted in the Department of Microbiology. The data was collected from the records of the Department for a period of one year (January 2014-December 2014). Results: Among 128 blood samples processed from clinically suspected neonatal septicaemic cases, 45 (35.1%) samples showed growth. Among 45 isolates, 22 were from early onset septicaemia (EOS) and 23 were from Late Onset Septicaemia (LOS). Among 45 culture positives, 32 (71.1%) were from males and 13(28.9%) were from females, thus showing a male preponderance. Klebsiella pneumoniae and Candida were the major isolates, 37.8% each. The antibiotic sensitivity showed that most of the Gram negative bacteria were highly resistant to the commonly used antibiotics like Ampicillin and Gentamicin. Gram positive bacteria showed 100% sensitivity to linezolid and Gram negative bacteria showed more than 90% sensitivity to imipenem. Conclusions: Development of sepsis in neonates is a medical emergency and generally the clinicians do not wait for microbiology report and start treatment empirically. If local microbiological databases are available with information regarding the commonly isolated organisms and their drug resistance patterns, it can help the clinicians in empirical therapy.

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“…Placezek et al and Jiang et al reported group B Streptococci and E. coli as the frequently encountered pathogens in early onset sepsis and CONS, E.coli and Klebsiella as commonly isolated organisms in late onset sepsis. 19,20 In the present study, as shown in Table 4, Klebsiella isolates were more susceptible to imipenem (45%); cefotaxime, vancomycin, levofloxacin (36%); ciprofloxacin, ceftazidime, piperacillin-tazobactum (18%); gentamycin, amikacin (19%); ofloxacin, chloramphenicol (9%). Mathur et al reported that only 3.3% of Klebsiella isolates were sensitive to ampicillin and 39.3% were sensitive to gentamycin.…”

Section: Discussionmentioning

confidence: 88%

Prospective study to evaluate the risk factors associated with mortality in neonatal septicemia

Khurana

Malik

Narang

et al. 2017

Int J Contemp Pediatr

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Background: Neonatal sepsis is a clinical syndrome of bacteremia characterized by systemic signs and symptoms of infection in the first month of life. Neonatal sepsis refers to infection occuring within the neonatal period i.e. first 28 days of life for a term baby and up to 4 weeks beyond the expected date of delivery in a preterm baby. Neonatal sepsis is one of the major cause of neonatal morbidity and mortality.Methods: The present study is a prospective observational study conducted in the neonatal intensive care unit (NICU) of Sri Guru Ram Das Institute of Medical Sciences and Research (SGRDIMSAR), Sri Amritsar over a period of one year from January 2015 to January 2016. Aim of the study is to know the incidence of neonatal sepsis, to study bacteriology of neonatal septicemia and to evaluate the risk factors associated with mortality in neonatal sepsis in our hospital.Results: During the study period (January 2015 to January 2016), 727 neonates were admitted in NICU of SGRDIMSAR, Sri Amritsar. Out of them, 109 neonates were diagnosed as having septicemia. Incidence of neonatal sepsis in our hospital in this study is 149.9/1000 neonatal admissions. 59 (54.1%) neonates had positive blood culture. Out of 109 septic neonates, 50 died and 59 survived. Mortality observed in the present study is 45.9%.Conclusions: It is concluded from present study that the main factors associated with neonatal mortality are low birth weight, prematurity, positive blood culture, neutropenia and prolonged prothrombin time. Some of the risk factors like low birth weight and prematurity are preventable by proper antenatal check ups and measures can be taken for safe and hygienic delivery. Babies with risk factors should be monitored closely for early detection of sepsis and the neonates with sepsis having abnormal laboratory parameters should be subjected to appropriate therapeutic intervention in order to decrease the mortality.

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Early and late neonatal septicaemia.

Cited by 101 publications

References 8 publications

Granulocyte and Granulocyte-Macrophage Colony-Stimulating Factors in Cord and Maternal Serum at Delivery

Granulocyte and Granulocyte-Macrophage Colony-Stimulating Factors in Cord and Maternal Serum at Delivery

Prevalence of neonatal septicaemia in a tertiary care hospital in Mandya, Karnataka, India

Prospective study to evaluate the risk factors associated with mortality in neonatal septicemia

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