Early and late lung radiographic injury following stereotactic body radiation therapy (SBRT)

Trovò, Marco; Linda, Anna; Naqa, Issam El; Javidan-Nejad, Cylen; Bradley, Jeffrey D.

doi:10.1016/j.lungcan.2009.09.006

Cited by 105 publications

(85 citation statements)

References 18 publications

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“…7) The radiological image reveals bronchiectasis similar to but less extensive than conventional radiation fibrosis, scar-like fibrosis (linear opacity in the region of the original tumor) and mass-like fibrosis. 5,6) Therefore, in this case, advanced adhesions formed without tumor invasion. This should be taken into consideration when performing salvage surgery.…”

Section: Discussionmentioning

confidence: 70%

“…The radiological image reveals grand grass attenuation (GGA). 5,6) In the later phase (after two years), these changes become localized to the area of the radiation port, with fibrosis affecting all compartments of the lung, most notably the lung parenchyma and vasculature. 7) The radiological image reveals bronchiectasis similar to but less extensive than conventional radiation fibrosis, scar-like fibrosis (linear opacity in the region of the original tumor) and mass-like fibrosis.…”

Section: Discussionmentioning

confidence: 99%

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Combined Aortic Resection and Stent Graft Insertion for Local Recurrence of Metastatic Lung Carcinoma Following Stereotactic Radiotherapy: A Case Report

Dejima

Matsutani

Imazuru

et al. 2016

ATCS

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Combined Aortic Resection and Stent Graft Insertion for Local Recurrence of Metastatic Lung Carcinoma Following Stereotactic Radiotherapy: A Case Report

Dejima

Matsutani

Imazuru

et al. 2016

ATCS

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“…Ground glass appearance is common, and subcategories are recognizable to radiation oncologists and others familiar with CT interpretation [17,18]. The late phase of radiation fibrosis frequently appears as a well-defined area of volume loss with a linear scar or consolidation, parenchymal distortion and traction bronchiectasis that conforms to the treatment portals which may either stabilize or evolve up to 24 months.…”

Section: Discussionmentioning

confidence: 99%

“…Shrinkage of the region of fibrotic consolidation or a more sharply defined demarcation between normal and irradiated lung parenchyma may occur as the process progresses. These findings are sometimes associated with ipsilateral displacement of the mediastinum and adjacent pleural thickening or effusion [17,18].…”

Section: Discussionmentioning

confidence: 99%

Differentiating Radiation Changes from Local Recurrence after SBRT for Lung Cancer: The Need for Better Decision Guidelines

Weiss

Newman

Shah

2017

IJRRT

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Radiographic lung changes and fibrosis are near ubiquitous observations on CT imaging following the treatment of non-small cell lung cancer with stereotactic body radiation therapy (SBRT). The distinction between these radiographic changes and a local cancer recurrence in a timely and accurate fashion is critical for successful salvage therapy as well as to avoid potentially detrimental overtreatment. Nonetheless, an adequate, widely accepted and validated approach for post-treatment surveillance and identification of recurrences is unavailable. This article relates a case wherein the failure of close follow up imaging and uncertainty in the interpretation of imaging resulted in overtreatment. It also identifies some of the shortcomings in the current attempts to develop an appropriate post-SBRT follow up schedule, examines the physiological and radiographic post-SBRT radiation changes and reviews the pertinent literature.

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“…1 Ima ging tech ni qu es, ma inly X-ray and com pu ted to mography (CT), ha ve so far be en used in the early diag no sis of RI LI and the spec trum of CT chan ges oc cur ring af ter RT have been well-des cri bed in li te ra tu re. [2][3][4][5][6] CT-in teg ra ted po sit ron emis si on to mog raphy (PET/CT) with 18F-flu o ro de oxy glu co se (FDG) is cur rently a well-known mo da lity for re ve a ling me ta bo lic as pects of tu mors. Ho we ver FDG, as a glu co se ana log, is ta ken up by high-glu co se-con suming cells and its up ta ke is not a spe ci fic mar ker of ma lig nancy.…”

mentioning

confidence: 99%

Radiation-Induced Lung Injury on PET/CT: Analysis of FDG Uptake Response within Specific Isodose Regions of Irradiation in Non-small Cell Lung Cancer Patients

Şen¹,

Akpinar²,

Özkan³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Inf lam ma tory res pon se as so ci a ted with ra di a ti on-in du ced lung in jury (RI LI) re sults in an in cre a sed 18F-flu o ro de oxy glu co se (FDG) up ta ke on po sit ron emis si on to mog raphy/com pu ted to mog raphy (PET/CT). In this study, we ai med to analy ze the deg re e of FDG up ta ke wit hin spe ci fic iso do se re gi ons (IR) of the ir ra di a ted lung using stan dar di zed up ta ke va lu e (SUV) me a su re ments, and to cor re la te post tre at ment FDG up take with ra di ot he rapy (RT) do se pa ra me ters, pa ti ent cha rac te ris tics and the ima ging ti me in ter val af ter RT comp le ti on. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Da ta from 30 pa ti ents with non-small cell lung can cer (NSCLC) who un der went FDG PET/CT ima ging at le ast 12 we eks (72-668 days) af ter comp le ti on of RT we re eva lu a ted. In each pa ti ent, side-by-si de vi su al re gis tra ti on of the tre at ment plan ning CT sli ces inc lu ding IR cur ves with the cor res pon ding PET/CT sli ces was per for med. Using SUV me a su re ments, FDG up ta ke le vels we re analy zed wit hin spe ci fic IRs of the ir ra di a ted lung. The sta tis ti cal dif fe ren ce bet we en SUV max of each IR was de ter mi ned. The RT do se pa rame ters, pa ti ent cha rac te ris tics and ti me in ter val bet we en RT and PET/CT we re tes ted for cor re la ti on with SUVmax of IRs. R Re e s su ul lt ts s: : The mean SUV max in the IRs of the lung that re ce i ved 2000-4000cGy was 1.51 ± 0.66 (me an ± SD) (min-max: 0.69-2.84), 4000-6000cGy was 2.67 ± 1.16 (min-max: 0.71-6.0), and >6000Gy was 3.55 ± 1.09 (min-max: 1.2-5.72). We fo und sta tis ti cally sig ni fi cant dif fe ren ces bet we en the SUV max va lu es of all IRs (SUV2000 vs. SUV4000, p= 0.001; SUV2000 vs.6000, p= 0.002; SUV4000 vs. 6000, p= 0.001). No sta tis ti cally sig ni fi cant corre la ti on was fo und bet we en SUV max and the ot her va ri ab les. C Co on nc c l lu u s si i o on n: : The fin dings of this study sho wed that, alt ho ugh so me over lap oc curs bet we en IRs, the deg re e of ra di a ti on-re la ted pa rench ymal FDG up ta ke gets hig her with in cre a sing do se le vels. Per sis tent high FDG up ta ke le vels may be ob ser ved in ra di a ti on fib ro sis are as on PET/CT even se ve ral months af ter RT.K Ke ey y W Wo or rd ds s: : Lung in jury; ra di ot he rapy; po sit ron-emis si on to mog raphy; flu o ro de oxy glu co se F18; lung ne op lasms Ö ÖZ ZE ET T A Am ma aç ç: : Rad yas yo na bağ lı ak ci ğer ha sa rı (RBAH) ile iliş ki li inf la ma tu var ya nıt po zit ron emis yon to mog rafi si/bil gi sa yar lı to mog ra fi de (PET/BT) art mış 18F-flo ro de ok sig lu koz (FDG) tu tu lu mu ile so nuç la nır. Bu ça lış mada, stan dar di ze tu tu lum de ğe ri (stan dard up ta ke va lu e; SUV) öl çüm le ri ni kul la na rak ışın lan mış ak ci ğe rin be lir li izo doz alan la rın da (İA) FDG tu tu lu mu nun de re ce si ni in ce le me yi ve te da vi son ra sı FDG tu tu lu mu ile rad yo ...

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Early and late lung radiographic injury following stereotactic body radiation therapy (SBRT)

Cited by 105 publications

References 18 publications

Combined Aortic Resection and Stent Graft Insertion for Local Recurrence of Metastatic Lung Carcinoma Following Stereotactic Radiotherapy: A Case Report

Combined Aortic Resection and Stent Graft Insertion for Local Recurrence of Metastatic Lung Carcinoma Following Stereotactic Radiotherapy: A Case Report

Differentiating Radiation Changes from Local Recurrence after SBRT for Lung Cancer: The Need for Better Decision Guidelines

Radiation-Induced Lung Injury on PET/CT: Analysis of FDG Uptake Response within Specific Isodose Regions of Irradiation in Non-small Cell Lung Cancer Patients

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