Early and late cortical reactivity to passively viewed emotional faces in pediatric bipolar disorder

Simonetti, Alessio; Lijffijt, Marijn; Kahlon, Ramandeep; Gandy, Kellen; Arvind, R; Amin, Pooja; Arciniegas, David B.; Swann, Alan C.; Soares, Jair C.; Saxena, Kirti

doi:10.1016/j.jad.2019.04.076

Cited by 16 publications

(7 citation statements)

References 68 publications

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“…Three studies ( Batty et al, 2011 ; Batty and Taylor, 2006 ; Meaux et al, 2014 ) included neutral stimuli and all six of the basic emotions. Most studies included adult stimuli, although Tye et al (2014) used child stimuli, whilst O’Connor et al (2005) and Simonetti et al (2019) included both child and adult stimuli. Studies generally incorporated either implicit ( n = 14) or explicit ( n = 4) tasks, whilst Wong et al (2008) included both.…”

Section: Resultsmentioning

confidence: 99%

“…Sample size across studies ranged from 26 ( Grunewald et al, 2019 ) to 188 ( Kujawa, Hajcak et al, 2012 ), with a median of 48 participants. Most studies employed an explicit task design, with the exception of Kujawa et al (2012a , 2012b ) and Simonetti et al (2019) . Generally, adult stimuli were used in the FEP task, although James et al (2018) and Woody et al (2019) included morphed child stimuli.…”

Section: Resultsmentioning

confidence: 99%

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The development of neural responses to emotional faces: A review of evidence from event-related potentials during early and middle childhood

Bigelow

Clark

Enticott

2021

Developmental Cognitive Neuroscience

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Highlights We examine the development of facial emotion processing (FEP) event-related potentials (ERPs) in early-to-middle childhood. We provide a systematic review with a meta-regression component across 34 studies. FEP ERPs continue to develop into middle childhood. Results suggest the development of FEP may differ to previously reported findings of processing neutral faces.. Substantial methodological differences accentuate need for additional research.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The development of neural responses to emotional faces: A review of evidence from event-related potentials during early and middle childhood

Bigelow

Clark

Enticott

2021

Developmental Cognitive Neuroscience

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“…As mentioned before, altered activity of cortical areas belonging to AN are involved in emotion regulation. Poor emotion regulation does not allow for the inhibition of prepotent emotional impulses coming from subcortical areas, such as the amygdala ( 80 ). Poor activity in the FPN and CON might facilitate the transition of prepotent emotionally states into action through failure of response inhibition processes., i.e., the capability of withholding or canceling routinized, ongoing, or prepotent responses to enable goal-oriented behaviors ( 81 , 82 ).…”

Section: Discussionmentioning

confidence: 99%

Cortical Correlates of Impulsive Aggressive Behavior in Pediatric Bipolar Disorder

et al. 2021

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Background: Impulsive aggression represents a frequent characteristic of pediatric bipolar disorder (PBD). Cortical alterations associated with impulsive aggression and its multiple facets have not been investigated yet in youth with bipolar disorder.Aim: To investigate the relationship between cortical thickness and facets of impulsive aggression in youth with PBD.Materials and Methods: Twenty-three youth with PBD and 23 healthy controls (HC) were administered the aggression questionnaire (AQ) and underwent 3T magnetic resonance imaging scan. Cortical thickness was assessed with FreeSurfer. Canonical correlation analyses were used to investigate the relationship between AQ total and subscale scores and cortical thickness in youth with PBD.Results: Youth with PBD had increased scores in the subscales of AQ-anger and AQ-hostility and cortical thinning in in areas belonging to the affective network (AN), frontoparietal network (FPN) and cingulo-opercular network (CON), i.e., right rostral anterior cingulate, right caudal anterior cingulate, right lateral orbitofrontal, right medial orbitofrontal, left and right inferior parietal, left posterior cingulate, left and right supramarginal left lingual cortices. Greater thickness in these networks positively correlated with the AQ-hostility subscale and negatively correlated with AQ-anger subscale.Conclusions: The opposite patterns observed between areas belonging to AN, FPN, CON, and the two facets of IA, namely anger and hostility, corroborate clinical findings supporting the different nature of these two constructs.

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“…Event-related potential (ERP) is a tool for a functional measure of brain activity that occurs time-locked to external stimuli and reflects successive stages of information processing. The ERP is a technique that can provide an analysis of neural activity with the high temporal resolution and high informative power on neural alterations in several disorders including schizophrenia, affective disorders, and substance abuse disorders (7)(8)(9). Previous studies have indicated that ERP P300 (P300) reflects cognitive control-related processing; therefore, P300 is thought to serve as a marker of cognitive control processes (10,11).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Control Deficits in Alcohol Dependence Are a Trait- and State-Dependent Biomarker: An ERP Study

et al. 2020

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Alcohol dependence (AD) presents cognitive control deficits. Event-related potential (ERP) P300 reflects cognitive control-related processing. The aim of this study was to investigate whether cognitive control deficits are a trait biomarker or a state biomarker in AD. Participants included 30 AD patients and 30 healthy controls (HCs). All participants were measured with P300 evoked by a three-stimulus auditory oddball paradigm at a normal state (time 1, i.e., just after the last alcohol intake) and abstinence (time 2, i.e., just after a 4-week abstinence). The results showed that for P3a and P3b amplitude, the interaction effect for group × time point was significant, the simple effect for group at time 1 level and time 2 level was significant, and the simple effect for time point at AD group level was significant; however, the simple effect for time point at HC group level was not significant. Above results indicated that compared to HCs, AD patients present reductions of P3a/3b amplitude, and after 4-week alcohol abstinence, although P3a/3b amplitudes were improved, they were still lower than those of HCs. For P3a and P3b latencies, no significant differences were observed. These findings conclude that AD patients present cognitive control deficits that are reflected by P3a/3b and that cognitive control deficits in AD are trait- and state-dependent. The implication of these findings is helpful to understand the psychological and neural processes for AD, and these findings suggest that improving the cognitive control function may impact the treatment effect for AD.

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Early and late cortical reactivity to passively viewed emotional faces in pediatric bipolar disorder

Cited by 16 publications

References 68 publications

The development of neural responses to emotional faces: A review of evidence from event-related potentials during early and middle childhood

The development of neural responses to emotional faces: A review of evidence from event-related potentials during early and middle childhood

Cortical Correlates of Impulsive Aggressive Behavior in Pediatric Bipolar Disorder

Cognitive Control Deficits in Alcohol Dependence Are a Trait- and State-Dependent Biomarker: An ERP Study

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