Early age of onset, brain morphological changes and non-consistent motor asymmetry in schizophrenic patients

Tabarés‐Seisdedos, Rafael; Arias, Julio Sanjuán; Gómez-Beneyto, Manuel; Cercós, Carmen Leal

doi:10.1016/s0920-9964(98)00174-1

Cited by 13 publications

(3 citation statements)

References 36 publications

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“…It has been suggested that crossed dominance (i.e., left-handedness in combination with right-eyedness or righthandedness in combination with left-eyedness) is indicative of neurodevelopmental abnormalities. In right-handed schizophrenic patients, crossed dominance was associated with earlier clinical onset and smaller brain size (Tabares Seisdedos, Sanjuan Arias, Gomez-Beneyto, & Leal Cercos, 1999). In a sample of individuals with mental handicaps however, the prevalence of crossed dominance was similar to the prevalence found in the general population (Robison, Block, Boudreaux, & Flora, 1999).…”

Section: Discussionmentioning

confidence: 87%

Increased Prevalences of Left-handedness and Left-eye Sighting Dominance in Individuals with Williams-Beuren Syndrome

Strien

Haselen

Hagen

et al. 2005

Journal of Clinical and Experimental Neuropsychology

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Handedness and eye sighting dominance were assessed in a sample of 50 individuals (25 male, 25 female; aged 5-38 years) with Williams-Beuren syndrome (WBS). The prevalences of left-handedness and left-eyedness were compared to the normative prevalences in the general population. We found significantly higher prevalences of left-handedness and left-eyedness in the WBS sample. The higher prevalences were more salient in younger than in older individuals and in male than in female individuals. We suggest that the increased prevalence of left-handedness in WBS is a consequence of a slower maturation rate, which allows deviation from a predetermined laterality pattern.

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Section: Discussionmentioning

confidence: 87%

Increased Prevalences of Left-handedness and Left-eye Sighting Dominance in Individuals with Williams-Beuren Syndrome

Strien

Haselen

Hagen

et al. 2005

Journal of Clinical and Experimental Neuropsychology

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“…All patients completed a battery of tests, which were described in three previous publications [ 36 , 7 , 37 ]. These tests were used to measure eight neurocognitive domains, in the following sequence.…”

Section: Methodsmentioning

confidence: 99%

The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia

et al. 2010

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BackgroundAtypical antipsychotics provide better control of the negative and affective symptoms of schizophrenia when compared with conventional neuroleptics; nevertheless, their heightened ability to improve cognitive dysfunction remains a matter of debate. This study aimed to examine the changes in cognition associated with long-term antipsychotic treatment and to evaluate the effect of the type of antipsychotic (conventional versus novel antipsychotic drugs) on cognitive performance over time.MethodsIn this naturalistic study, we used a comprehensive neuropsychological battery of tests to assess a sample of schizophrenia patients taking either conventional (n = 13) or novel antipsychotics (n = 26) at baseline and at two years after.ResultsContinuous antipsychotic treatment regardless of class was associated with improvement on verbal fluency, executive functions, and visual and verbal memory. Patients taking atypical antipsychotics did not show greater cognitive enhancement over two years than patients taking conventional antipsychotics.ConclusionsAlthough long-term antipsychotic treatment slightly improved cognitive function, the switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of these cognitive deficits.

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“…On the same day, psychotic and other psychiatric symptoms were rated according to the Positive and Negative Syndrome Scale (PANSS) [18]. The Motor Dominance Demonstration Test [19]was employed to evaluate hand preference. The vocabulary subtest of the Wechsler Adult Intelligence Scale-Revised (WAIS-R) [20]was used to estimate the premorbid intelligence quotient (PIQ) since it has been proposed as the best single measure of both verbal and general mental abilities [17].…”

Section: Methodsmentioning

confidence: 99%

Persistent Cognitive Dysfunctions in Bipolar I Disorder and Schizophrenic Patients: A 3-Year Follow-Up Study

Balanzá‐Martínez

Tabarés‐Seisdedos

Selva-Vera

et al. 2005

Psychother Psychosom

Self Cite

142

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Background: Neurocognitive impairment has consistently been considered a central and stable feature in schizophrenia. As this possibility has been far less studied in bipolar disorder, we aimed to prospectively investigate the stability and specificity of cognitive performance in bipolar disorder compared to schizophrenia. Methods: Fifteen DSM-IV bipolar type I patients and 15 schizophrenic patients were assessed twice with a comprehensive neuropsychological battery and the Positive and Negative Syndrome Scale over a 3-year follow-up. The cognitive performance of the groups was compared at baseline and 3 years later as a mean with that of 26 healthy volunteers. Endpoint and baseline assessments were also compared for each patient group in order to evaluate the stability of cognitive impairment. Results: At both time points, bipolar and schizophrenic patients showed significant deficits on most of the cognitive tasks compared to healthy subjects. Overall, the cross-sectional cognitive profile was similar for both patient groups. Moreover, after controlling for age and length of illness, the two groups’ cognitive function did not differ over time in any test. With the exception of the Stroop color-word interference task, performance at baseline for each test but neither length of illness nor diagnostic category predicted the endpoint performance. Conclusion: This preliminary study suggests that cognitive impairment is also mainly stable over time in bipolar I disorder and thus not specific to schizophrenia.

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Early age of onset, brain morphological changes and non-consistent motor asymmetry in schizophrenic patients

Cited by 13 publications

References 36 publications

Increased Prevalences of Left-handedness and Left-eye Sighting Dominance in Individuals with Williams-Beuren Syndrome

Increased Prevalences of Left-handedness and Left-eye Sighting Dominance in Individuals with Williams-Beuren Syndrome

The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia

Persistent Cognitive Dysfunctions in Bipolar I Disorder and Schizophrenic Patients: A 3-Year Follow-Up Study

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