Early Administration of Low-Dose Aspirin for the Prevention of Severe and Mild Preeclampsia: A Systematic Review and Meta-Analysis

Abstract

Low-dose aspirin initiated at or before 16 weeks reduces the risk of severe preeclampsia, but not mild preeclampsia.

Validation of metabolomic models for prediction of early-onset preeclampsia

“…[4][5][6] However, after 16 weeks, aspirin prophylaxis had significantly reduced effectiveness. Developing biomarkers for the diagnosis or prediction of PE is now a priority.…”

The first trimester: Prediction and prevention of the great obstetrical syndromes

“…First, there is now evidence that early (<16 weeks' gestation) intervention, through the prescription of aspirin, can reduce the prevalence of early-onset disease [22,23]. Second, first-trimester screening for aneuploidy has led to earlier attendance for antenatal care.…”

First trimester erythropoietin (EPO) serum concentration as a potential marker for abnormal placentation disorders. Reference values for erythropoietin (EPO) concentration at 11–13+6 weeks of gestation

“…Again for such small samples (five), statistical testing is inapplicable. 5. Blood count: red blood cells (RBC), white blood cells (WBC), hemoglobin (Hb) concentration, hematocrit (Ht) and platelets (Plt) 6.…”

“…This involves maternal characteristics, measurements of maternal mean arterial pressure (MAP), measurements of uterine artery pulsatility index (PI) and placental growth factor (PlGF) concentration in maternal serum. Recent meta-analysis has shown that the initiation of low-dose aspirin prophylaxis at or before 16 weeks gestation may result in 50% reduction of early onset preeclampsia [5].…”