Early activation does not translate into effector differentiation of peripheral CD8T cells during the acute phase of Kawasaki disease

Ehara, Hiroshi; Kiyohara, Koji; Izumisawa, Yasuhiro; Ito, Taichi

doi:10.1016/j.cellimm.2010.07.003

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…This data was further corroborated by another research group, which observed that the number of HLA-DR + CD8 + T cells does not increase during the acute phase of KD (30). Further, in patients with systemic lupus erythematosus, another disease that affects the immune system, the percentage HLA-DR + CD8 + T cells was found to be higher among patients with active systemic lupus erythematosus compared to those with quiescent systemic lupus erythematosus (31).…”

Section: Discussionsupporting

confidence: 63%

Relationship between T-cell HLA-DR expression and intravenous immunoglobulin treatment response in Kawasaki disease

et al. 2015

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Background: Kawasaki disease (KD) is an acute febrile illness associated with the development of vasculitis. Administration of intravenous immunoglobulin (IVIG) is the standard treatment for KD. However, IVIG treatment is not effective in approximately 15% of children with KD. Some reports have presented evidence of immunological responses in IVIG-resistant KD patients.We assessed the possibility that T-cell activation is a contributing mechanism underlying this phenomenon.

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Section: Discussionsupporting

confidence: 63%

Relationship between T-cell HLA-DR expression and intravenous immunoglobulin treatment response in Kawasaki disease

et al. 2015

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“…Similarly, Ehara et al . showed a marked increase in the proportion of CD69 + /CD8 + T cells [20]. Conversely, various reports have shown that CD4 and CD8 T cell activation did not change, as determined by the expression of the CD69 early activation antigen [9,10,21].…”

Section: Discussionmentioning

confidence: 81%

Increased frequency of immunoglobulin (Ig)A-secreting cells following Toll-like receptor (TLR)-9 engagement in patients with Kawasaki disease

Giordani¹,

Quaranta²,

Marchesi

et al. 2010

Clinical and Experimental Immunology

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SummaryKawasaki disease (KD) is an acute vasculitis affecting mainly infants and children. Human B cells express Toll-like receptor (TLR)-9, whose natural ligands are unmethylated cytosine-guanine dinucleotide (CpG) motifs characteristic of bacterial DNA. The aim of this study was to clarify the pathogenesis of KD analysing the activation status of peripheral blood mononuclear cells (PBMC), focusing on B lymphocyte activation and functions. Ten patients and 10 age-matched healthy donors were recruited from the Bambino Gesù Hospital of Rome, Italy and enrolled into this study. We determined phenotype profile and immunoglobulin (Ig) production of PBMC from KD patients and age-matched controls. We found that the frequency of CD19 + B lymphocytes and CD19 + /CD86 + activated B lymphocytes from KD patients during the acute phase before therapy was increased significantly. Moreover, B lymphocytes of acute-phase KD patients were more prone to CpG oligodeoxynucleotide (ODN) activation compared with the age-matched controls, as assessed by a significant increase of the number of IgA-secreting cells (SC). In the same patients we found a marked increase of IgM, IgG, interleukin (IL)-6 and tumour necrosis factor (TNF)-a production compared with the control group. In addition, in two convalescent KD patients, conventional treatment with intravenous immunoglobulin (IVIG) restored the normal frequency of CD19 + B cells, the number of IgA-, IgMand IgG-SC and the production of IL-6 and TNF-a. Our findings indicate that the percentages of peripheral B lymphocytes of acute-phase KD patients are increased and are prone to bacterial activation in terms of increased numbers of IgA-SC and increased production of IL-6 and TNF-a inflammatory cytokines. Thus, our data support the hypothesis of an infectious triggering in KD.

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“…Accumulated evidences suggest that peripheral CD8 + T cells may be functionally suppressed in acute phase of KD. Previous studies have shown a reduction in the total number of CD8 + T cells in the peripheral blood of KD patients . However, the expression of NKG2D on NK cells and CD8 + T cells in the acute phase of KD is still required to be investigated.…”

Section: Introductionmentioning

confidence: 99%

Aberrantly Decreased Levels of NKG2D Expression in Children with Kawasaki Disease

Yang

et al. 2013

Scand J Immunol

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This study is designed to investigate the changes of NKG2D expression on CD8 + T cells and CD3 + T cells expression in acute phase of KD were significantly lower than those in normal controls (P < 0.05), and the levels of NKG2D expression in the patients with coronary artery lesion (KD-CAL + ) were lower than those in patients with KD-CAL À . There was an upregulated tendency after treatment with IVIG. We found higher expression levels of proinflammatory cytokines from MC, such as IL-1b, IL-6 and TNF-a in patients with KD compared with the healthy controls (P < 0.05). The concentrations of IL-7 and IL-15 were significantly decreased in acute phase of KD (P < 0.05) and to some extent elevated after therapy with IVIG (P < 0.05), while antagonistic cytokines like IFN-c were increased in acute phase of KD (P < 0.05) and reduced after therapy with IVIG (P < 0.05). These results suggest that aberrantly decreased levels of NKG2D expression on NK cells and CD8 + T cells might be one of the factors led to disturbed immunological function in patients with KD. Cytokines milieu could be important factors causing reduced expression of NKG2D.

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Early activation does not translate into effector differentiation of peripheral CD8T cells during the acute phase of Kawasaki disease

Cited by 12 publications

References 20 publications

Relationship between T-cell HLA-DR expression and intravenous immunoglobulin treatment response in Kawasaki disease

Relationship between T-cell HLA-DR expression and intravenous immunoglobulin treatment response in Kawasaki disease

Increased frequency of immunoglobulin (Ig)A-secreting cells following Toll-like receptor (TLR)-9 engagement in patients with Kawasaki disease

Aberrantly Decreased Levels of NKG2D Expression in Children with Kawasaki Disease

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