A new network flow solution method is designed to determine optimal traffic routing efficiently for the evacuation of networks with several threat zones and with nonuniform threat levels across zones. The objective is to minimize total exposure (as duration and severity) to the threat for all evacuees during the evacuation. The problem is formulated as a minimum cost dynamic flow problem coupled with traffic dynamic constraints. The traffic flow dynamic constraints are enforced by the well-known point queue and spatial queue models in a time-expanded network presentation. The key to the efficiency of the proposed method is that, for any feasible solution, the algorithm can find and can cancel multiple negative cycles (including the cycle with the largest negative cost) with a single shortest path calculation made possible by applying a proposed transformation to the original problem. A cost transformation function and a multisource shortest path algorithm are proposed to facilitate the efficient detection and cancelation of negative cycles. Zone by zone, negative cycles are canceled at the border links of the zones. The solution method is proved to be optimal. The algorithm is implemented, tested, and verified to be optimal for a midsized example problem.Over the past few decades, many human-caused and natural disasters (e.g., hurricanes, building fires, bomb threats, and chemical spills) have occurred. The increasing number and intensity of emergencies raise interest in the optimal preparation of an evacuation plan before an emergency arises. Evacuation problems have been studied extensively by many researchers in various modeling paradigms, with different selections of decision variables, objective functions, and constraint sets; moreover, the solution methods have generated a wide spectrum of approaches suitable for problem-specific purposes, contexts, capabilities, and performances.Evacuation management policies can be modeled, enhanced, and optimized with mathematical optimization techniques. Tactical decisions that provide the scope and context of the evacuation plan are made in various ways depending on the evacuation control tools available to the decision makers. Common decisions selected for optimization focus on generating evacuation advisory information, including departure times, evacuation routes, and destination choices for evacuees (1-5). Additional tactical decisions may entail optimizing traffic control and reconfiguring the network to take advantage of flexibilities in the network and create a more efficient evacuation plan (6-9).Without considering the fine details of traffic flow dynamics on roadways, an evacuation can be formulated as a general dynamic network flow problem, which optimizes the evacuation objective as a network flow problem on a dynamic network. Minimizing the network clearance time is one of the common objectives in the evacuation literature; its dynamic flow model counterpart is known as the quickest flow problem (10-13). Another evacuation optimization objective is to min...