Earlier versus later cognitive event-related potentials (ERPs) in attention-deficit/hyperactivity disorder (ADHD): A meta-analysis

Kaiser, Anna; Aggensteiner, Pascal-M.; Baumeister, Sarah; Holz, Nathalie E.; Banaschewski, Tobias; Brandeis, Daniel

doi:10.1016/j.neubiorev.2020.01.019

Cited by 109 publications

(101 citation statements)

References 102 publications

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“…fronto-parietal network [FPN], default mode network [DMN] and ventro-attentional network [VAN]) are associated with reduced P3 amplitude [ 19 , 20 ]; as well as with increased reaction time variability (RTV) [ 21 ], a key cognitive impairment associated with ADHD and thought to reflect lapses in attention [ 22 ]. Based on a recent meta-analysis [ 23 ], a moderate attenuation in P3 has been reliably identified in across dozens of studies. Reduced P3 has also often been reported during MW episodes during sustained attention tasks (e.g., SART) [ 13 , 14 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological correlates of spontaneous mind wandering in attention-deficit/hyperactivity disorder

Bozhilova

Cooper

Kuntsi

et al. 2020

Behavioural Brain Research

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Section: Introductionmentioning

confidence: 99%

Electrophysiological correlates of spontaneous mind wandering in attention-deficit/hyperactivity disorder

Bozhilova

Cooper

Kuntsi

et al. 2020

Behavioural Brain Research

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“…However, previous research showed heterogeneous results for this component (Fallgatter et al, 2004;Shahaf et al, 2015). In addition, a recent meta-analysis by Kaiser et al (2020) could not confirm amplitude reductions for this component and concluded that reduced amplitudes of the nogo N2 could be characteristic for a subgroup of the ADHD population. Indeed, pronounced N2 reductions were found particularly in younger ADHD patients of about 10 years (Johnstone et al, 2013).…”

Section: Amplitude In µVmentioning

confidence: 88%

“…ADHD patients in this study had a mean age of 13 years. As cognitive impairments in ADHD and neurophysiologic correlates vary with age (Marx et al, 2010;Kaiser et al, 2020) it is possible that the sensitivity of the introduced paradigm for cognitive deficits depends on the investigated age group. Further, in this study patients with comorbid disorders were excluded, because they differ from patients with ADHD only, in cognitive and ERP profiles (Banaschewski et al, 2003;Noordermeer et al, 2015).…”

Section: Amplitude In µVmentioning

confidence: 99%

“…Accordingly, in healthy adults with high impulsivity reduced nogo P3 amplitudes have been demonstrated (Ruchsow et al, 2008). Reduced amplitudes of the nogo P3 component are one of the most robust ERP findings in ADHD (Kaiser et al, 2020) and have been associated with response inhibition impairments in ADHD patients (Johnstone et al, 2013).…”

Section: Introductionmentioning

confidence: 97%

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Economical Assessment of Working Memory and Response Inhibition in ADHD Using a Combined n-back/Nogo Paradigm: An ERP Study

Breitling-Ziegler

Tegelbeckers

Flechtner

et al. 2020

Front. Hum. Neurosci.

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The development of cognitive interventions in attention-deficit/hyperactivity disorder (ADHD) often requires the assessment of multiple cognitive functions. However, experimental settings consisting of various tasks are particularly strenuous for patients and can thus result in poor data quality. For the economical assessment of working memory and response inhibition, this study aims to validate a combined n-back/nogo paradigm by comparing it to single task versions and to demonstrate its applicability for ADHD research. Twenty-five healthy individuals and 34 ADHD patients between 9 and 16 years participated in this event-related potential (ERP) study. Healthy controls underwent single task versions of a 2-back working memory task and a go/nogo response inhibition task as well as the introduced combined 2-back/nogo task. This combined task demonstrated a comparable ERP structure for working memory and response inhibition aspects as single task versions. Behaviorally, higher working memory performance during the combined paradigm indicated lower task difficulty, while high correlations between combined and single task versions still indicated valid working memory measures. For response inhibition performance, different task versions resulted in similar outcomes. The application of the combined n-back/nogo paradigm in ADHD patients revealed the expected working memory and response inhibition deficits, increased omission errors, reaction times, and standard deviation of reaction time, as well as diminished n-back P3 and nogo P3 amplitudes. We conclude that the combined n-back/nogo task is an effective paradigm for the economical assessment of working memory and response inhibition deficits in ADHD on a behavioral and neurophysiological level.

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“…In general, cognitive ERPs represent stimulus-locked time epochs in the EEG that can be related to distinct cognitive processes. (IV) In addition, a recent meta-analysis summarized previous study results on earlier versus later cognitive ERPs in ADHD compared to non-ADHD populations [32]. Results show that for early ERPs ADHD patients present shorter Go-P100-latencies when compared to non-ADHD.…”

Section: Introductionmentioning

confidence: 98%

EEG Data Quality: Determinants and Impact in a Multicenter Study of Children, Adolescents, and Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)

et al. 2021

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Electroencephalography (EEG) represents a widely established method for assessing altered and typically developing brain function. However, systematic studies on EEG data quality, its correlates, and consequences are scarce. To address this research gap, the current study focused on the percentage of artifact-free segments after standard EEG pre-processing as a data quality index. We analyzed participant-related and methodological influences, and validity by replicating landmark EEG effects. Further, effects of data quality on spectral power analyses beyond participant-related characteristics were explored. EEG data from a multicenter ADHD-cohort (age range 6 to 45 years), and a non-ADHD school-age control group were analyzed (ntotal = 305). Resting-state data during eyes open, and eyes closed conditions, and task-related data during a cued Continuous Performance Task (CPT) were collected. After pre-processing, general linear models, and stepwise regression models were fitted to the data. We found that EEG data quality was strongly related to demographic characteristics, but not to methodological factors. We were able to replicate maturational, task, and ADHD effects reported in the EEG literature, establishing a link with EEG-landmark effects. Furthermore, we showed that poor data quality significantly increases spectral power beyond effects of maturation and symptom severity. Taken together, the current results indicate that with a careful design and systematic quality control, informative large-scale multicenter trials characterizing neurophysiological mechanisms in neurodevelopmental disorders across the lifespan are feasible. Nevertheless, results are restricted to the limitations reported. Future work will clarify predictive value.

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Earlier versus later cognitive event-related potentials (ERPs) in attention-deficit/hyperactivity disorder (ADHD): A meta-analysis

Cited by 109 publications

References 102 publications

Electrophysiological correlates of spontaneous mind wandering in attention-deficit/hyperactivity disorder

Electrophysiological correlates of spontaneous mind wandering in attention-deficit/hyperactivity disorder

Economical Assessment of Working Memory and Response Inhibition in ADHD Using a Combined n-back/Nogo Paradigm: An ERP Study

EEG Data Quality: Determinants and Impact in a Multicenter Study of Children, Adolescents, and Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)

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