Earlier is Better. New Options for Acute Heart Failure: When, Who, How Much?

Abstract

Heart failure (HF) is a major public health problem characterised by a high rate of hospitalisation and death. The risk is maximal for patients admitted with acute heart failure (AHF). New therapies with solid proof of mortality reduction in both groups of patients with reduced and preserved ejection fraction (EF) are now available (valsartan/sacubitril and SGLT2 inhibitors). The purpose of this article is to review the main data available and to clarify the role of these new therapies in AHF. The precise moment of initiating these therapies is still a matter of debate. This paper presents the recommended criteria for clinical stability that the clinician could use in deciding to initiate therapy. There is a growing amount of evidence that initiating these therapies sooner provides more benefits to patients.

Motivating Protective Behavior against COVID-19: Fear Versus Hope

“…In line with extant research (e.g., Graef & Henning, 2020;Liu & Liu, 2020), further research should account for media attention, media coverage, and governmental communication strategies because of their influence on people's threat perceptions and coping appraisal, for instance, through drastic language and war metaphors. While fear strongly motivates people in the short run, research documented manifold negative health consequences of fear in the long run (e.g., Nechita et al, 2018;Seiler et al, 2020). In contrast, this study pointed out that hope can even trump fear.…”

“…Jørgensen et al (2021) emphasize that even though fear works to predict compliance with recommended protective behavior, there are negative implications of anxiety for mental health and society. Other researchers have also illustrated the disruptive impact of fear and stress on people's physical and mental health-reaching from immune system dysfunction to suicidal thoughts (Ahorsu et al, 2020;Brod, Rattazzi, Piras, & D'Acquisto, 2014;Nechita et al, 2018;Seiler et al, 2020;S ¸ims ¸ir et al, 2021). According to Kompaniyets et al (2021), along with obesity and diabetes, anxiety and fear-related disorders are the strongest risk factors for severe COVID-19 illness and death.…”

Dynamic effective connectivity among large‐scale brain networks mediates risk of anxiety

“…High prevalence rate, comorbidity, and chronicity make WHO rank anxiety as the ninth largest cause of health-related disability (Disease et al, 2017). Globally, anxiety has become one of the main reasons for obtaining psychosocial care, resulting in high social and personal costs (Nechita et al, 2018).…”

“…High prevalence rate, comorbidity, and chronicity make WHO rank anxiety as the ninth largest cause of health‐related disability (Disease et al, 2017). Globally, anxiety has become one of the main reasons for obtaining psychosocial care, resulting in high social and personal costs (Nechita et al, 2018). According to some estimates in the last century, the direct and indirect costs of anxiety in the United States are approximately 46.6 billion dollars (DuPont et al, 1996).…”

The Relationship between Internality and Self-development of Psychology Students: the Effect of Optimistic Attributional Style

“…High internality is found correlating with stress caused by assuming too much responsibility, unrealistic expectation of the control of all outcomes, feelings of guilt, excessive selfcriticism, anxiety, and obsession with control (April, Dharani, & Peters, 2012) and can lead to the manifestations of maladaptation (Karas' , 2017). However, it is known that the manifestations of anxiety and stress have a negative impact on mental health, motivation for success, and personal activity to achieve goals (Nechita, Nechita, & Motorga, 2018). While some students improve their academic performance after admitting their guilt for academic failures, others, on the contrary, leave the university because of the conclusion that they are unable to study well.…”