Earlier and more targeted treatment of neonatal sepsis

Özenci, Volkan; Schubert, Ulf

doi:10.1111/apa.14597

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…There is a lack of data on the extent to which the pathogen spectrum in the case of neonatal sepsis matches that of the mother. There is a large and good body of data on the general pathogen spectrum in neonatal sepsis, which is consistent with our results, as well as with the theoretical pathways of transmission [11,30,31,32]. However, to date there has been no data on how often there is a match between the pathogen spectrum of mother and child; we are presenting this kind of data for the first time in this study.…”

Section: Staphylococcus Capitissupporting

confidence: 89%

“…Zur Frage, inwieweit das Erregerspektrum im Falle einer neonatalen Sepsis mit dem Spektrum der Mutter übereinstimmt, gibt es kaum Daten. Es existiert zwar eine breite und gute Datenlage zum allgemeinen Erregerspektrum der neonatalen Sepsis, was auch mit unseren Ergebnissen übereinstimmt, sowie auch zu den theoretischen Transmissionswegen [11,30,31,32]. Aber Daten, wie häufig eine Übereinstimmung zwischen dem Erregerspektrum von Mutter und Kind vorliegt, fehlen bisher und wurden hier erstmalig dargestellt.…”

Section: Diskussionunclassified

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Possible Rates of Detection of Neonatal Sepsis Pathogens in the Context of Microbiological Diagnostics in Mothers – Real World Data

Kuld,

Krauth,

Kühr

et al. 2023

Geburtshilfe Frauenheilkd

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The aim of this study was to identify the rate of detection of neonatal sepsis pathogens in maternal microbiological smears.This is a retrospective study conducted at a Level 1 perinatal center in the context of routine care from 2014 to 2019. For all premature infants and neonates with neonatal sepsis, the neonatal and maternal microbiological findings were examined to see if there was a match.During the study period, a total of 948 premature or newborn infants were identified as having a neonatal infection. Among all of the premature or newborn infants, 209 (22%) met the diagnostic criteria for neonatal sepsis; of these, 157 were premature births and 52 were full-term births. We evaluated the microbiological findings for these 209 mother and child pairs. No pathogens were detected in 27 out of 157 mothers of premature infants (17.1%) and in 31 out of 52 mothers of full-term infants (59.6%). In the premature infant group there were pairs with matching pathogens in 30 out of 130 cases (23.1%, 95% CI: 16.1–31.3), and in the full-term infant group there was a match in 4 out of 21 cases (19%, 95% CI: 5.4–41.9). The number needed to test to have a 90% probability of success for pathogen detection varies between 9 and 11 in the most favorable case and 26 and 32 in the least favorable case, depending on the evaluation method.In cases of neonatal sepsis, the sepsis-causing pathogen was successfully detected through prior analysis of a maternal smear in 7% of full-term infants and in 19% of premature infants. The number needed to test was relatively high in all groups. The value of maternal smears for identifying neonatal sepsis-causing pathogens needs to be critically questioned.

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Section: Staphylococcus Capitissupporting

confidence: 89%

Section: Diskussionunclassified

Possible Rates of Detection of Neonatal Sepsis Pathogens in the Context of Microbiological Diagnostics in Mothers – Real World Data

Kuld,

Krauth,

Kühr

et al. 2023

Geburtshilfe Frauenheilkd

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“…The main agents responsible for sepsis are group B Streptococcus (GBS), Escherichia coli, and coagulase-negative Staphylococci (CONS) [124]. However, this scenario may be modified depending on the use of antibiotics and/or the implementation of non-culture diagnostic techniques [125].…”

Section: Microbiome and Sepsis In The Newbornmentioning

confidence: 99%

The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review

et al. 2020

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Pregnancy induces a number of immunological, hormonal, and metabolic changes that are necessary for the mother to adapt her body to this new physiological situation. The microbiome of the mother, the placenta and the fetus influence the fetus growth and undoubtedly plays a major role in the adequate development of the newborn infant. Hence, the microbiome modulates the inflammatory mechanisms related to physiological and pathological processes that are involved in the perinatal progress through different mechanisms. The present review summarizes the actual knowledge related to physiological changes in the microbiota occurring in the mother, the fetus, and the child, both during neonatal period and beyond. In addition, we approach some specific pathological situations during the perinatal periods, as well as the influence of the type of delivery and feeding.

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“…The authors concluded that appropriate microbiological molecular screening methods and strict infection control measures are important, in order to control an outbreak. Readers may also be interested in the paper by Özenci and Schubert , which evaluated the implementation of an earlier, and more targeted, treatment of neonatal sepsis.…”

Section: Learning From Bacterial Outbreaks In Two Neonatal Intensive mentioning

confidence: 99%