EANM practice guideline for quantitative SPECT-CT

Dickson, John; Armstrong, Ian; Gabiña, Pablo Mínguez; Denis-Bacelar, Ana M.; Krizsán, Áron Krisztián; Gear, Jonathan; Wyngaert, Tim Van den; Geus‐Oei, Lioe‐Fee de; Herrmann, Ken

doi:10.1007/s00259-022-06028-9

Cited by 37 publications

(28 citation statements)

References 86 publications

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“…For 166 Ho, the 22 mm sphere unexpectedly had a similar CRC value as the 17 mm sphere. This could be due to the sphere position in the phantom and the larger detector radius in the lateral position when using auto-contouring [ 18 ]. For the 166 Ho measurement with the obese body phantom setup the CRC of the 22 mm sphere was similar to the CRC of the standard phantom setup measurement, but the CRC of the 17 mm sphere was lower.…”

Section: Discussionmentioning

confidence: 99%

Gamma camera imaging characteristics of 166Ho and 99mTc used in Selective Internal Radiation Therapy

Kästner,

Braune,

Brogsitter

et al. 2024

EJNMMI Phys

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Background The administration of a 166Ho scout dose is available as an alternative to 99mTc particles for pre-treatment imaging in Selective Internal Radiation Therapy (SIRT). It has been reported that the 166Ho scout dose may be more accurate for the prediction of microsphere distribution and the associated therapy planning. The aim of the current study is to compare the scintigraphic imaging characteristics of both isotopes, considering the objectives of the pre-treatment imaging using clinically geared phantoms. Methods Planar and SPECT/CT images were obtained using a NEMA image quality phantom in different phantom setups and another body-shaped phantom with several inserts. The influence of collimator type, count statistics, dead time effects, isotope properties and patient obesity on spatial resolution, contrast recovery and the detectability of small activity accumulations was investigated. Furthermore, the effects of the imaging characteristics on personalized dosimetry are discussed. Results The images with 99mTc showed up to 3 mm better spatial resolution, up to two times higher contrast recovery and significantly lower image noise than those with 166Ho. The contrast-to-noise ratio was up to five times higher for 99mTc than for 166Ho. Only when using 99mTc all activity-filled spheres could be distinguished from the activity-filled background. The measurements mimicking an obese patient resulted in a degraded image quality for both isotopes. Conclusions Our measurements demonstrate better scintigraphic imaging properties for 99mTc compared to 166Ho in terms of spatial resolution, contrast recovery, image noise, and lesion detectability. While the 166Ho scout dose promises better prediction of the microsphere distribution, it is important to consider the inferior imaging characteristics of 166Ho, which may affect individualized treatment planning in SIRT.

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Section: Discussionmentioning

confidence: 99%

Gamma camera imaging characteristics of 166Ho and 99mTc used in Selective Internal Radiation Therapy

Kästner,

Braune,

Brogsitter

et al. 2024

EJNMMI Phys

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“…Per routine clinical practice, patients consented to a scan by a trained nuclear medicine professional, including the consent to use the patients' anonymized images for the purposes of teaching and audits. Whilst not currently the national standard for neuroimaging, hybrid SPECT-CT has become the clinic standard for other nuclear medicine imaging [23]; however, the modality is increasingly being recognized within neuroimaging, as scatter and attenuation correction help produce superior images and improved quantification [23,24].…”

Section: Methodsmentioning

confidence: 99%

Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism

Missir

Begley

Jessop

et al. 2023

Nuclear Medicine Communications

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Aim [123]I-Ioflupane (DaTSCAN) binds to the presynaptic dopamine transporter (DAT) and with a lower affinity to the serotonin transporter (SERT). We aimed to develop a novel method to quantify absolute uptake in the striatal (predominantly DAT binding) and extra-striatal regions (mainly SERT binding) using single-photon computed tomography-computed tomography (SPECT-CT) DaTSCAN and to improve DaTSCAN image quality. Method Twenty-six patients with Parkinsonism underwent DaTSCAN SPECT-CT prospectively. The scans were visually analyzed independently by two experienced reporters. Specific binding ratios (SBRs) from Chang attenuation corrected SPECT were obtained using GE DaTQuant. Normalized concentrations and specific uptakes (NSU) from measured attenuation and modelled scatter-corrected SPECT-CT were obtained using HERMES Hybrid Recon and Affinity and modified EARL volumes of interest. Results Striatal NSU and SBR positively correlate (R = 0.65–0.88, P = 0.00). SBR, normalized concentrations, and NSU box plots differentiated between scans without evidence of dopaminergic deficit and abnormal scans. Interestingly, body weight inversely correlated with normalized concentrations values in extra-striatal regions [frontal (R = 0.81, P = 0.00); thalamus (R = 0.58, P = 0.00); occipital (R = 0.69, P = 0.00)] and both caudate nuclei [R = 0.42, P = 0.03 (Right), R = 0.52, P = 0.01 (Left)]. Both reporters noted improved visual quality of SPECT-CT versus SPECT images for all scans. Conclusion DaTSCAN SPECT-CT resulted in more accurate quantification, improved image quality, and enabled absolute quantification of extra-striatal regions. More extensive studies are required to establish the full value of absolute quantification for diagnosis and monitoring the progression of neurodegenerative disease, to assess an interplay between DAT and SERT, and to verify serotonin and DATs are potentially DATs are dysfunctional in obesity.

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“…The SPECT image reconstruction was based on iterative OSEM with CT-based attenuation correction [32] and no inter-and/or post-filtering to avoid impacting the quantification [31]. Scatter windows were 22.6 keV width, wide enough to limit noise when using TEW [32].…”

Section: Determination Of Optimal Reconstruction Parameters For Quant...mentioning

confidence: 99%

Performance study of a 360° CZT camera for monitoring 177Lu-PSMA treatment

Vergnaud

Badel

Giraudet

et al. 2023

Preprint

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Background: The aim of this study was to investigate the quantification performance of a 360° CZT camera for 177Lu-based treatment monitoring. Methods: Three phantoms with known 177Lu activity concentrations were acquired: 1) a uniform cylindrical phantom for calibration, 2) a NEMA IEC body phantom for analysis of different-sized spheres to optimise quantification parameters, and 3) a phantom containing two large vials simulating organs at risk for tests Four sets of reconstruction parameters were tested: 1) Scatter, 2) Scatter and Point Spread Function Recovery (PSFR), 3) PSFR only and 4) Penalized likelihood option and Scatter, varying the number of updates (iterations × subsets) with CT based attenuation correction only. For each, activity concentration (ARC) and contrast recovery coefficients (CRC) were estimated as well as root mean square. Visualisation and quantification parameters were applied to reconstructed patient image data. Results: Optimised quantification parameters were determined to be: CT-based attenuation correction, scatter correction, 12 iterations, 8 subsets and no filter. ARC, CRC and RMS results were dependant on the methodology used for calculations. Two different reconstruction parameters were recommended for visualisation and for quantification. 3D whole-body SPECT images were acquired and reconstructed for 177Lu-PSMA patients in 2-3 times faster than the time taken for a conventional gamma camera. Conclusion: Quantification of whole-body 3D images of patients treated with 177Lu-PSMA is feasible and an optimised set of parameters has been determined. This camera greatly reduces procedure time whilst providing a final 3D whole-body image.

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EANM practice guideline for quantitative SPECT-CT

Cited by 37 publications

References 86 publications

Gamma camera imaging characteristics of 166Ho and 99mTc used in Selective Internal Radiation Therapy

Gamma camera imaging characteristics of 166Ho and 99mTc used in Selective Internal Radiation Therapy

Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism

Performance study of a 360° CZT camera for monitoring 177Lu-PSMA treatment

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